PMID- 34583633
OWN - NLM
STAT- MEDLINE
DCOM- 20220118
LR  - 20221207
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Sep 28
TI  - Transition from metabolically healthy to unhealth status associated with risk of 
      carotid artery plaque in Chinese adults.
PG  - 469
LID - 10.1186/s12872-021-02279-w [doi]
LID - 469
AB  - OBJECTIVE: We aimed to evaluate the association between the shift of metabolic 
      status and future risk of carotid artery plaque (CAP) in community-based Chinese 
      adults. METHODS: The current study included 9836 Chinese adults (4085 males and 
      5751 females, mean age 35.8 years) with metabolically healthy status at baseline 
      (2013). Metabolically healthy status was defined as no self-reported history of 
      metabolic diseases and cancer, and normal blood pressure, fasting blood glucose, 
      glycated hemoglobin A1c level, and lipid profiles. Metabolically unhealthy status 
      was defined if any of the following metabolic abnormalities were confirmed twice 
      during follow up: high blood pressure, impaired glucose regulation, high 
      triglycerides, high total cholesterol, high low-density lipoprotein cholesterols, 
      or low high-density lipoprotein cholesterols. The transition was confirmed if 
      participants' metabolic status shifted from baseline healthy to unhealthy status 
      during follow up (2014-2018). RESULTS: We have identified 133 incident cases of 
      CAP during follow up. Compared to those who remained metabolically healthy, the 
      transition to high blood pressure, high total cholesterol, and high low-density 
      lipoprotein cholesterols, were associated with high risk of developing carotid 
      artery plaque (Hazards ratios (HRs) ranged from 1.69 to 2.34; p < 0.05 for all). 
      The transition to impaired glucose regulation, high total triglycerides, and low 
      high-density lipoprotein cholesterols, were associated with high risk of carotid 
      artery plaque only in participants with metabolically healthy overweight at 
      baseline (HR ranged from 1.95 to 4.62; p < 0.05 for all). CONCLUSION: The 
      transition from baseline metabolically healthy status to unhealth status was 
      associated with high risk of incident CAP.
CI  - (c) 2021. The Author(s).
FAU - Tan, Tao
AU  - Tan T
AD  - Department of Clinical Nutrition, Ren Ji Hospital South Campus, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
FAU - Zhou, Yiquan
AU  - Zhou Y
AD  - Department of Clinical Nutrition, Ren Ji Hospital South Campus, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
FAU - Wan, Yanping
AU  - Wan Y
AD  - Department of Clinical Nutrition, Ren Ji Hospital South Campus, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
AD  - Shanghai Key Laboratory of Pediatrics Gastroenterology and Nutrition, Shanghai, 
      China.
FAU - Fan, Zhuping
AU  - Fan Z
AD  - Department of Digestion, Ren Ji Hospital South Campus, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai, China.
FAU - Xu, Renying
AU  - Xu R
AD  - Department of Clinical Nutrition, Ren Ji Hospital South Campus, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. 
      xurenying7465@126.com.
AD  - Shanghai Key Laboratory of Pediatrics Gastroenterology and Nutrition, Shanghai, 
      China. xurenying7465@126.com.
FAU - Gao, Xiang
AU  - Gao X
AD  - Department of Nutrition Science, The Pennsylvania State University, State 
      College, PA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210928
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Carotid Artery Diseases/blood/diagnostic imaging/*epidemiology/physiopathology
MH  - China/epidemiology
MH  - Disease Progression
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Health Status
MH  - Humans
MH  - Incidence
MH  - Lipids/blood
MH  - Male
MH  - Metabolic Diseases/blood/diagnosis/*epidemiology/physiopathology
MH  - Middle Aged
MH  - *Plaque, Atherosclerotic
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
PMC - PMC8477551
OTO - NOTNLM
OT  - Adults
OT  - Carotid artery plaque (CAP)
OT  - Metabolically healthy status
OT  - Metabolically unhealthy status
COIS- The authors declared no conflict of interests.
EDAT- 2021/09/30 06:00
MHDA- 2022/01/19 06:00
PMCR- 2021/09/28
CRDT- 2021/09/29 05:35
PHST- 2021/06/13 00:00 [received]
PHST- 2021/09/20 00:00 [accepted]
PHST- 2021/09/29 05:35 [entrez]
PHST- 2021/09/30 06:00 [pubmed]
PHST- 2022/01/19 06:00 [medline]
PHST- 2021/09/28 00:00 [pmc-release]
AID - 10.1186/s12872-021-02279-w [pii]
AID - 2279 [pii]
AID - 10.1186/s12872-021-02279-w [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2021 Sep 28;21(1):469. doi: 10.1186/s12872-021-02279-w.