PMID- 34584585
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 1895-5770 (Print)
IS  - 1897-4317 (Electronic)
IS  - 1895-5770 (Linking)
VI  - 16
IP  - 3
DP  - 2021
TI  - Analysis of the prevalence of Helicobacter pylori infection and the effectiveness 
      of eradication schemes in patients with the upper gastrointestinal tract 
      disorders (according to the results of 13C-urea breath tests for 2006-2019).
PG  - 229-234
LID - 10.5114/pg.2021.108976 [doi]
AB  - INTRODUCTION: The problem of Helicobacter pylori is relevant due to the high 
      frequency of stomach and duodenum erosions and ulcers, as well as the possible 
      development of metaplasia and gastric cancer. Therefore, it is especially 
      important to study the dynamics of H. pylori infection and monitor the 
      effectiveness of eradication schemes in different regions of Ukraine. AIM: To 
      study the dynamics of H. pylori infection and to evaluate the effectiveness of H. 
      pylori eradication schemes in patients with upper gastrointestinal tract 
      disorders - residents of the Vinnytsia region. MATERIAL AND METHODS: We 
      retrospectively analysed 2205 results of 13C-urea breath tests, performed during 
      2006-2019 in the National Pirogov Memorial Medical University, Vinnytsya on an 
      infrared analyser. RESULTS: It was found that patients with upper 
      gastrointestinal tract disorders since 2009 had significantly reduced primary H. 
      pylori infection. Among the schemes designed according to the Maastricht 
      recommendations, the most effective were as follows: proton pump inhibitor (PPI) 
      + clarithromycin (Clar) + amoxicillin (Amox) - 81.6%, PPI + Clar + Amox + bismuth 
      subcitrate (Bi) - 87%, and PPI + tetracycline (TC) + metronidazole derivatives 
      (MNZ) + Bi - 83.9%. The lowest efficiency was recorded for the scheme PPI + Clar 
      + MNZ, at 68.1%. CONCLUSIONS: Despite the gradual decrease in H. pylori infection 
      in the general population, its prevalence remains quite high among the elderly. 
      This dictates that a thorough examination be carried out for patients with 
      disorders of the upper G.I. tract to detect the presence of H. pylori infection, 
      and if infection is detected, the correct selection of eradication therapy.
CI  - Copyright (c) 2021 Termedia.
FAU - Kondratiuk, Nataliia
AU  - Kondratiuk N
AD  - Primary Care Centre of Khmelnitskyi District, Khmelnitskyi, Ukraine.
FAU - Paliy, Iryna
AU  - Paliy I
AD  - National Pirogov Memorial Medical University, Vinnytsya, Ukraine.
FAU - Zaika, Serhii
AU  - Zaika S
AD  - National Pirogov Memorial Medical University, Vinnytsya, Ukraine.
LA  - eng
PT  - Journal Article
DEP - 20210917
PL  - Poland
TA  - Prz Gastroenterol
JT  - Przeglad gastroenterologiczny
JID - 101280380
PMC - PMC8456768
OTO - NOTNLM
OT  - 13C-urea breath test
OT  - Helicobacter pylori infection
COIS- The authors declare no conflict of interest.
EDAT- 2021/09/30 06:00
MHDA- 2021/09/30 06:01
PMCR- 2021/01/01
CRDT- 2021/09/29 06:54
PHST- 2020/09/18 00:00 [received]
PHST- 2020/11/12 00:00 [accepted]
PHST- 2021/09/29 06:54 [entrez]
PHST- 2021/09/30 06:00 [pubmed]
PHST- 2021/09/30 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 45093 [pii]
AID - 10.5114/pg.2021.108976 [doi]
PST - ppublish
SO  - Prz Gastroenterol. 2021;16(3):229-234. doi: 10.5114/pg.2021.108976. Epub 2021 Sep 
      17.