PMID- 34584875
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 2224-4344 (Print)
IS  - 2224-4344 (Electronic)
IS  - 2224-4336 (Linking)
VI  - 10
IP  - 8
DP  - 2021 Aug
TI  - An analysis of macular ganglion cell complex in 7-year-old children in China: the 
      Anyang Childhood Eye Study.
PG  - 2052-2062
LID - 10.21037/tp-21-323 [doi]
AB  - BACKGROUND: This study used spectral-domain optical coherence tomography (SD-OCT) 
      imaging to describe the distribution of macular ganglion cell complex (GCC) 
      thickness and its association with ocular and systemic parameters in 7-year-old 
      children in China. METHODS: The study involved a school-based, cross-sectional 
      analysis of the Anyang Childhood Eye Study (ACES) and included 2,505 first-grade 
      students from urban areas in Anyang, Henan Province, Central China. All 
      participants underwent systemic and ocular examinations. Both GCC and retinal 
      nerve fiber layer (RNFL) thickness were measured using the iVue-100 OCT (Optovue, 
      Fremont, CA, USA). Intraocular pressure (IOP) was recorded with noncontact 
      tonometer (Huvitz, HNT-7000). Axial length (AL) was measured using optical 
      biometry (Lenstar LS 900, Haag-Streit Diagnostics, Koniz, Switzerland). RESULTS: 
      The mean GCC thickness was 95.31+/-7.67 microm. GCC thickness had negative associations 
      with AL (r=-0.124, P<0.001), cup-to-disc (C-D) area ratio (r=-0.068, P=0.0033), 
      horizontal C-D (H C-D) ratio (r=-0.048, P=0.0384), and vertical C-D (V C-D) ratio 
      (r=-0.074, P=0.0013). Positive correlations were found with spherical equivalent 
      (SE) (r=0.080, P=0.0001), RNFL thickness (r=0.363, P<0.001), height (r=0.059, 
      P=0.0036), fovea parameters, disc area (r=0.078, P=0.0007), rim area (r=0.115, 
      P<0.001), rim volume (r=0.119, P<0.001), and optic nerve head volume (r=0.097, 
      P<0.001). GCC thickness had no significant association with IOP, age, sex, or 
      weight, waist, or head circumference. CONCLUSIONS: This study provides normative 
      GCC data for 7-year-old healthy children in China. The findings support an 
      association between GCC and AL, SE, RNFL, height, and C-D ratio in children.
CI  - 2021 Translational Pediatrics. All rights reserved.
FAU - Wang, Xiaolei
AU  - Wang X
AD  - Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical 
      University, Beijing, China.
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & 
      Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical 
      University, Beijing, China.
FAU - Li, Shi-Ming
AU  - Li SM
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & 
      Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical 
      University, Beijing, China.
FAU - Liu, Luoru
AU  - Liu L
AD  - Department of Ophthalmology, Anyang Eye Hospital, Anyang, China.
FAU - Li, Siyuan
AU  - Li S
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & 
      Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical 
      University, Beijing, China.
FAU - Li, Lei
AU  - Li L
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & 
      Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical 
      University, Beijing, China.
FAU - Kang, Mengtian
AU  - Kang M
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & 
      Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical 
      University, Beijing, China.
FAU - Wei, Shifei
AU  - Wei S
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & 
      Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical 
      University, Beijing, China.
FAU - Wang, Ningli
AU  - Wang N
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & 
      Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical 
      University, Beijing, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Transl Pediatr
JT  - Translational pediatrics
JID - 101649179
PMC - PMC8429863
OTO - NOTNLM
OT  - Macular ganglion cell complex (macular GCC)
OT  - axial length (AL)
OT  - intraocular pressure (IOP)
OT  - retinal nerve fiber layer (RNFL)
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at https://dx.doi.org/10.21037/tp-21-323). The authors have no 
      conflicts of interest to declare.
EDAT- 2021/09/30 06:00
MHDA- 2021/09/30 06:01
PMCR- 2021/08/01
CRDT- 2021/09/29 06:56
PHST- 2021/06/15 00:00 [received]
PHST- 2021/08/12 00:00 [accepted]
PHST- 2021/09/29 06:56 [entrez]
PHST- 2021/09/30 06:00 [pubmed]
PHST- 2021/09/30 06:01 [medline]
PHST- 2021/08/01 00:00 [pmc-release]
AID - tp-10-08-2052 [pii]
AID - 10.21037/tp-21-323 [doi]
PST - ppublish
SO  - Transl Pediatr. 2021 Aug;10(8):2052-2062. doi: 10.21037/tp-21-323.