PMID- 34585369
OWN - NLM
STAT- MEDLINE
DCOM- 20220119
LR  - 20230812
IS  - 1735-546X (Electronic)
IS  - 1735-1308 (Linking)
VI  - 18
IP  - 6
DP  - 2021 Sep 29
TI  - Urine Biomarkers for the Diagnosis of Bladder Cancer: a Network Meta-Analysis.
PG  - 623-632
LID - 10.22037/uj.v18i.6254 [doi]
AB  - PURPOSE: To identify effective urine biomarkers for bladder cancer diagnosis. 
      MATERIALS AND METHODS: This meta-analysis was conducted following the guidelines 
      of the Meta-Analyses (PRISMA) statement. Relevant studies were searched from the 
      PubMed, Embase, and Cochrane Library databases. Heterogeneity tests were 
      performed using Q statistics and I2 tests to determine the use of the random or 
      fixed effects model. A direct comparison meta-analysis and network meta-analysis 
      were conducted. The effect values are presented as odds ratios and 95% confidence 
      intervals. Sensitivity analysis and consistency tests were performed. RESULTS: 
      Fifty-eight studies with 12,038 participants were included. Direct comparison 
      meta-analysis showed statistically significant differences in bladder cancer 
      antigen (BTA) trak vs. nuclear matrix protein 22 (NMP22), BTA stat vs. urine 
      cytology (UC), and fluorescence in situ hybridization (FISH) vs. UC, among the 
      sensitivity indicators. Among the specificity indicators, there were 
      statistically significant differences in BTA trak vs. UC, ImmunoCyt (immunocyte) 
      vs. NMP22, and BTA stat vs. FISH. Among the positive predictive indicators, NMP22 
      vs. UC, BTA stat vs. UC, and FISH vs. NMP22 showed statistically significant 
      differences. Among the negative predictive indicators, the differences in FISH 
      vs. UC, FISH vs. NMP22, and hyaluronidase 1 (HYAL-1) vs. UC were statistically 
      significant. Among the accuracy indicators, FISH vs. NMP22, FISH vs. UC, and 
      HYAL-1 vs. UC showed statistically significant differences. Network meta-analysis 
      showed that HYAL-1, urothelial carcinoma associated 1 (UCA1) and survivin had the 
      highest sensitivity, while UC had the lowest sensitivity. The specificity of UC, 
      FISH, and HYAL-1 was the highest, while that of UCA1 was the lowest. In terms of 
      positive predictive indicators, UC, FISH, and HYAL-1 had the highest positive 
      predictive value, while the BTA group had the lowest positive predictive value. 
      In terms of negative predictive indicators, HYAL-1, UCA1, and survivin had the 
      highest negative predictive value, while UC had the lowest negative predictive 
      value. In terms of accuracy indicators, HYAL-1, UCA1, and survivin had the 
      highest accuracy, while UC had the lowest accuracy. CONCLUSION: HYAL-1 and 
      survivin are suitable urine biomarkers for bladder cancer diagnosis.
FAU - Dong, Ying
AU  - Dong Y
AD  - Schools of Medicine and Nursing Sciences, Huzhou University, Huzhou Central 
      Hospital, Huzhou, Zhejiang, 313000, China . dongying@zjhu.edu.cn.
FAU - Zhang, Ting
AU  - Zhang T
AD  - Schools of Medicine and Nursing Sciences, Huzhou University, Huzhou, Zhejiang, 
      313000, China. grape_chang@163.com.
FAU - Li, Xining
AU  - Li X
AD  - Schools of Medicine and Nursing Sciences, Huzhou University, Huzhou, Zhejiang, 
      313000, China. 290089532@qq.com.
FAU - Yu, Feng
AU  - Yu F
AD  - Schools of Medicine and Nursing Sciences, Huzhou University, Huzhou, Zhejiang, 
      313000, China. yufeng@zjhu.edu.cn.
FAU - Yu, Hongwei
AU  - Yu H
AD  - Schools of Medicine and Nursing Sciences, Huzhou University, Huzhou, Zhejiang, 
      313000, China. yuhw@zjhu.edu.cn.
FAU - Shao, Shenwen
AU  - Shao S
AD  - Schools of Medicine and Nursing Sciences, Huzhou University, Huzhou, Zhejiang, 
      313000, China. shuolan01348577@21cn.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20210929
PL  - Iran
TA  - Urol J
JT  - Urology journal
JID - 101286676
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Antigens, Neoplasm
MH  - Biomarkers, Tumor
MH  - *Carcinoma, Transitional Cell
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Network Meta-Analysis
MH  - Sensitivity and Specificity
MH  - *Urinary Bladder Neoplasms/diagnosis
EDAT- 2021/09/30 06:00
MHDA- 2022/01/20 06:00
CRDT- 2021/09/29 07:07
PHST- 2021/09/30 06:00 [pubmed]
PHST- 2022/01/20 06:00 [medline]
PHST- 2021/09/29 07:07 [entrez]
AID - 6254 [pii]
AID - 10.22037/uj.v18i.6254 [doi]
PST - epublish
SO  - Urol J. 2021 Sep 29;18(6):623-632. doi: 10.22037/uj.v18i.6254.