PMID- 34588500
OWN - NLM
STAT- MEDLINE
DCOM- 20211227
LR  - 20220910
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Sep 29
TI  - Prevalence of elevated serum fatty acid synthase in chronic limb-threatening 
      ischemia.
PG  - 19272
LID - 10.1038/s41598-021-98479-7 [doi]
LID - 19272
AB  - There are currently no serum-based evaluations that can corroborate the severity 
      of peripheral artery disease (PAD). In this cross-sectional study, we assessed 
      the prevalence of elevated serum fatty acid synthase (cFAS) in patients with 
      chronic limb-threatening ischemia (CLTI) and evaluated the accuracy of its use in 
      detecting this condition. Preoperative fasting serum samples from 87 patients 
      undergoing vascular intervention were collected between October 2014 and 
      September 2016. Median age was 62 years, with 56 (64%) men, and 32 (37%) with 
      CLTI. We found that elevated cFAS content (OR 1.17; 95% CI 1.04-1.31), type 2 
      diabetes (T2D; OR 5.22; 95% CI 1.77-15.4), and smoking (OR 3.53; 95% CI 
      1.19-10.5) were independently associated with CLTI and could detect the presence 
      of CLTI with 83% accuracy (95% CI 0.74-0.92). Furthermore, serum FAS content was 
      positively correlated with FAS content in femoral artery plaque in patients with 
      severe PAD ([Formula: see text] = 0.22; P =  0.023). Finally, significantly 
      higher co-localization of FAS and ApoB were observed within lower extremity 
      arterial media (P < .001). Our findings indicate that serum FAS content is a 
      marker for disease severity in patients with PAD, independent of concomitant T2D 
      and smoking, and may play a key role in FAS and ApoB peripheral plaque 
      progression.
CI  - (c) 2021. The Author(s).
FAU - Tay, Shirli
AU  - Tay S
AD  - Section of Vascular Surgery, Department of Surgery, Washington University School 
      of Medicine, St. Louis, MO, USA.
FAU - De Silva, Gayan S
AU  - De Silva GS
AD  - Section of Vascular Surgery, Department of Surgery, Washington University School 
      of Medicine, St. Louis, MO, USA.
FAU - Engel, Connor M
AU  - Engel CM
AD  - Section of Vascular Surgery, Department of Surgery, Washington University School 
      of Medicine, St. Louis, MO, USA.
FAU - Harroun, Nikolai
AU  - Harroun N
AD  - Section of Vascular Surgery, Department of Surgery, Washington University School 
      of Medicine, St. Louis, MO, USA.
FAU - Penrose, Amanda S
AU  - Penrose AS
AD  - Section of Vascular Surgery, Department of Surgery, Washington University School 
      of Medicine, St. Louis, MO, USA.
FAU - Desai, Kshitij A
AU  - Desai KA
AD  - Section of Vascular Surgery, Department of Surgery, Washington University School 
      of Medicine, St. Louis, MO, USA.
FAU - Yan, Yan
AU  - Yan Y
AD  - Division of Public Health Sciences, Department of Surgery, Washington University 
      School of Medicine, St. Louis, MO, USA.
FAU - Semenkovich, Clay F
AU  - Semenkovich CF
AD  - Division of Endocrinology, Metabolism and Lipid Research, Department of Internal 
      Medicine, Washington University School of Medicine, St. Louis, MO, USA.
FAU - Zayed, Mohamed A
AU  - Zayed MA
AD  - Section of Vascular Surgery, Department of Surgery, Washington University School 
      of Medicine, St. Louis, MO, USA. zayedm@wustl.edu.
AD  - Division of Molecular Cell Biology, Washington University School of Medicine, St. 
      Louis, MO, USA. zayedm@wustl.edu.
AD  - Department of Biomedical Engineering, Washington University, McKelvey School of 
      Engineering, St. Louis, MO, USA. zayedm@wustl.edu.
AD  - Veterans Affairs St. Louis Health Care System, St. Louis, MO, USA. 
      zayedm@wustl.edu.
LA  - eng
GR  - K08 HL132060/HL/NHLBI NIH HHS/United States
GR  - R01 DK101392/DK/NIDDK NIH HHS/United States
GR  - R01 HL153262/HL/NHLBI NIH HHS/United States
GR  - P30 DK020579/DK/NIDDK NIH HHS/United States
GR  - P30 DK020589/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
DEP - 20210929
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
RN  - EC 2.3.1.85 (FASN protein, human)
RN  - EC 2.3.1.85 (Fatty Acid Synthase, Type I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Chronic Limb-Threatening Ischemia/blood/*diagnosis/surgery
MH  - Cross-Sectional Studies
MH  - Fatty Acid Synthase, Type I/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Preoperative Period
MH  - Severity of Illness Index
PMC - PMC8481229
COIS- The authors declare no competing interests.
EDAT- 2021/10/01 06:00
MHDA- 2021/12/28 06:00
PMCR- 2021/09/29
CRDT- 2021/09/30 06:27
PHST- 2021/05/30 00:00 [received]
PHST- 2021/08/30 00:00 [accepted]
PHST- 2021/09/30 06:27 [entrez]
PHST- 2021/10/01 06:00 [pubmed]
PHST- 2021/12/28 06:00 [medline]
PHST- 2021/09/29 00:00 [pmc-release]
AID - 10.1038/s41598-021-98479-7 [pii]
AID - 98479 [pii]
AID - 10.1038/s41598-021-98479-7 [doi]
PST - epublish
SO  - Sci Rep. 2021 Sep 29;11(1):19272. doi: 10.1038/s41598-021-98479-7.