PMID- 34588535
OWN - NLM
STAT- MEDLINE
DCOM- 20220106
LR  - 20230620
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Sep 29
TI  - Development of coronary dysfunction in adult progeny after maternal engineered 
      nanomaterial inhalation during gestation.
PG  - 19374
LID - 10.1038/s41598-021-98818-8 [doi]
LID - 19374
AB  - Maternal exposure to environmental contaminants during pregnancy can profoundly 
      influence the risk of developing cardiovascular disease in adult offspring. Our 
      previous studies have demonstrated impaired cardiovascular health, microvascular 
      reactivity, and cardiac function in fetal and young adult progeny after maternal 
      inhalation of nano-sized titanium dioxide (nano-TiO(2)) aerosols during 
      gestation. The present study was designed to evaluate the development of 
      cardiovascular and metabolic diseases later in adulthood. Pregnant Sprague-Dawley 
      rats were exposed to nano-TiO(2) aerosols (~ 10 mg/m(3), 134 nm median diameter) 
      for 4 h per day, 5 days per week, beginning on gestational day (GD) 4 and ending 
      on GD 19. Progeny were delivered in-house. Body weight was recorded weekly after 
      birth. After 47 weeks, the body weight of exposed progeny was 9.4% greater 
      compared with controls. Heart weight, mean arterial pressure, and plasma 
      biomarkers of inflammation, dyslipidemia, and glycemic control were recorded at 
      3, 9 and 12 months of age, with no significant adaptations. While no clinical 
      risk factors (i.e., hypertension, dyslipidemia, or systemic inflammation) emerged 
      pertaining to the development of cardiovascular disease, we identified impaired 
      endothelium-dependent and -independent arteriolar dysfunction and cardiac 
      morphological alterations consistent with myocardial inflammation, degeneration, 
      and necrosis in exposed progeny at 12 months. In conclusion, maternal inhalation 
      of nano-TiO(2) aerosols during gestation may promote the development of coronary 
      disease in adult offspring.
CI  - (c) 2021. The Author(s).
FAU - Fournier, Sara B
AU  - Fournier SB
AD  - Environmental and Occupational Health Sciences Institute, Rutgers University, 170 
      Frelinghuysen Road, Piscataway, NJ, 08854, USA.
FAU - Lam, Vincent
AU  - Lam V
AD  - Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, 
      Rutgers University, 160 Frelinghuysen Rd., Piscataway, NJ, 08854, USA.
FAU - Goedken, Michael J
AU  - Goedken MJ
AD  - Research Pathology Services, Rutgers University, 41 Gordon Road, Piscataway, NJ, 
      08854, USA.
FAU - Fabris, Laura
AU  - Fabris L
AD  - Department of Material Science and Engineering, School of Engineering, Rutgers 
      University, 607 Taylor Rd., Piscataway, NJ, 08854, USA.
FAU - Stapleton, Phoebe A
AU  - Stapleton PA
AD  - Environmental and Occupational Health Sciences Institute, Rutgers University, 170 
      Frelinghuysen Road, Piscataway, NJ, 08854, USA. stapleton@eohsi.rutgers.edu.
AD  - Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, 
      Rutgers University, 160 Frelinghuysen Rd., Piscataway, NJ, 08854, USA. 
      stapleton@eohsi.rutgers.edu.
LA  - eng
GR  - P30 ES005022/ES/NIEHS NIH HHS/United States
GR  - R01 ES031285/ES/NIEHS NIH HHS/United States
GR  - R00 ES024783/ES/NIEHS NIH HHS/United States
GR  - T32 ES007148/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20210929
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Air Pollutants)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Administration, Inhalation
MH  - Air Pollutants/*toxicity
MH  - Animals
MH  - Animals, Newborn
MH  - Female
MH  - Heart Diseases/*chemically induced
MH  - Inhalation Exposure
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Nanostructures/*toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Titanium/*toxicity
PMC - PMC8481306
COIS- The authors declare no competing interests.
EDAT- 2021/10/01 06:00
MHDA- 2022/01/07 06:00
PMCR- 2021/09/29
CRDT- 2021/09/30 06:39
PHST- 2021/07/12 00:00 [received]
PHST- 2021/09/15 00:00 [accepted]
PHST- 2021/09/30 06:39 [entrez]
PHST- 2021/10/01 06:00 [pubmed]
PHST- 2022/01/07 06:00 [medline]
PHST- 2021/09/29 00:00 [pmc-release]
AID - 10.1038/s41598-021-98818-8 [pii]
AID - 98818 [pii]
AID - 10.1038/s41598-021-98818-8 [doi]
PST - epublish
SO  - Sci Rep. 2021 Sep 29;11(1):19374. doi: 10.1038/s41598-021-98818-8.