PMID- 34589097 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231103 IS - 1664-462X (Print) IS - 1664-462X (Electronic) IS - 1664-462X (Linking) VI - 12 DP - 2021 TI - Comprehensive Mechanism of Gene Silencing and Its Role in Plant Growth and Development. PG - 705249 LID - 10.3389/fpls.2021.705249 [doi] LID - 705249 AB - Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism. In plants, gene silencing occurs via transcriptional gene silencing (TGS) and post-transcriptional gene silencing (PTGS). TGS obscures transcription via the methylation of 5' untranslated region (5'UTR), whereas PTGS causes the methylation of a coding region to result in transcript degradation. In this review, we summarized the history and molecular mechanisms of gene silencing and underlined its specific role in plant growth and crop production. CI - Copyright (c) 2021 El-Sappah, Yan, Huang, Islam, Li, Wang, Khan, Zhao, Mir, Li, El-Tarabily and Abbas. FAU - El-Sappah, Ahmed H AU - El-Sappah AH AD - School of Agriculture, Forestry and Food Engineering, Yibin University, Yibin, China. AD - Genetics Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt. AD - Key Laboratory of Sichuan Province for Refining Sichuan Tea, Yibin, China. FAU - Yan, Kuan AU - Yan K AD - School of Agriculture, Forestry and Food Engineering, Yibin University, Yibin, China. AD - Key Laboratory of Sichuan Province for Refining Sichuan Tea, Yibin, China. FAU - Huang, Qiulan AU - Huang Q AD - School of Agriculture, Forestry and Food Engineering, Yibin University, Yibin, China. AD - Key Laboratory of Sichuan Province for Refining Sichuan Tea, Yibin, China. AD - College of Tea Science, Yibin University, Yibin, China. FAU - Islam, Md Monirul AU - Islam MM AD - College of Horticulture, Northwest A&F University, Xianyang, China. FAU - Li, Quanzi AU - Li Q AD - State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, Beijing, China. AD - Research Institute of Forestry, Chinese Academy of Forestry, Beijing, China. FAU - Wang, Yu AU - Wang Y AD - School of Agriculture, Forestry and Food Engineering, Yibin University, Yibin, China. AD - Key Laboratory of Sichuan Province for Refining Sichuan Tea, Yibin, China. FAU - Khan, Muhammad Sarwar AU - Khan MS AD - Center of Agriculture Biochemistry and Biotechnology, University of Agriculture, Faisalabad, Pakistan. FAU - Zhao, Xianming AU - Zhao X AD - School of Agriculture, Forestry and Food Engineering, Yibin University, Yibin, China. AD - Key Laboratory of Sichuan Province for Refining Sichuan Tea, Yibin, China. FAU - Mir, Reyazul Rouf AU - Mir RR AD - Division of Genetics and Plant Breeding, Faculty of Agriculture (FoA), Sher-e-Kashmir University of Agricultural Sciences and Technology (SKUAST-K), Sopore, India. FAU - Li, Jia AU - Li J AD - School of Agriculture, Forestry and Food Engineering, Yibin University, Yibin, China. AD - Key Laboratory of Sichuan Province for Refining Sichuan Tea, Yibin, China. FAU - El-Tarabily, Khaled A AU - El-Tarabily KA AD - Department of Biology, College of Science, United Arab Emirates University, Al-Ain, United Arab Emirates. AD - Harry Butler Institute, Murdoch University, Murdoch, WA, Australia. FAU - Abbas, Manzar AU - Abbas M AD - School of Agriculture, Forestry and Food Engineering, Yibin University, Yibin, China. AD - Key Laboratory of Sichuan Province for Refining Sichuan Tea, Yibin, China. LA - eng PT - Journal Article PT - Review DEP - 20210907 PL - Switzerland TA - Front Plant Sci JT - Frontiers in plant science JID - 101568200 PMC - PMC8475493 OTO - NOTNLM OT - CRISPR/Cas9 OT - RNAi OT - genomics imprinting OT - paramutation OT - post-transcriptional gene silencing OT - transcriptional gene silencing COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/10/01 06:00 MHDA- 2021/10/01 06:01 PMCR- 2021/01/01 CRDT- 2021/09/30 07:12 PHST- 2021/05/04 00:00 [received] PHST- 2021/08/10 00:00 [accepted] PHST- 2021/09/30 07:12 [entrez] PHST- 2021/10/01 06:00 [pubmed] PHST- 2021/10/01 06:01 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 10.3389/fpls.2021.705249 [doi] PST - epublish SO - Front Plant Sci. 2021 Sep 7;12:705249. doi: 10.3389/fpls.2021.705249. eCollection 2021.