PMID- 34589898
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211001
IS  - 2666-3546 (Electronic)
IS  - 2666-3546 (Linking)
VI  - 9
DP  - 2020 Dec
TI  - Sensory filtering disruption caused by poly I:C - Timing of exposure and other 
      experimental considerations.
PG  - 100156
LID - 10.1016/j.bbih.2020.100156 [doi]
LID - 100156
AB  - Maternal immune activation (MIA) in response to infection during pregnancy has 
      been linked through various epidemiological and preclinical studies to an 
      increased risk of neurodevelopmental disorders such as autism spectrum disorder 
      (ASD) and schizophrenia in exposed offspring. Sensory filtering disruptions occur 
      in both of these disorders and are typically measured using the acoustic startle 
      response in both humans and rodents. Our study focuses on characterizing the 
      baseline reactivity, habituation and prepulse inhibition (PPI) of the acoustic 
      startle response following exposure to MIA. We induced MIA using polyinosinic: 
      polycytidylic acid (poly I:C) at gestational day (GD) 9.5 or 14.5, and we tested 
      sensory filtering phenotypes in adolescent and adult offspring. Our results show 
      that startle reactivity was robustly increased in adult GD9.5 but not GD14.5 poly 
      I:C offspring. In contrast to some previous studies, we found no consistent 
      changes in short-term habituation, long-term habituation or prepulse inhibition 
      of startle. Our study highlights the importance of MIA exposure timing and 
      discusses sensory filtering phenotypes as they relate to ASD, schizophrenia and 
      the poly I:C MIA model. Moreover, we analyze and discuss the potential impact of 
      between- and within-litter variability on behavioural findings in poly I:C 
      studies.
CI  - (c) 2020 The Authors.
FAU - Haddad, Faraj L
AU  - Haddad FL
AD  - Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, The University 
      of Western Ontario, Canada.
FAU - Lu, Lu
AU  - Lu L
AD  - Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, The University 
      of Western Ontario, Canada.
AD  - Department of Neurology, West China Hospital of Sichuan University, Chengdu, 
      China.
FAU - Baines, Kelly J
AU  - Baines KJ
AD  - Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, The University 
      of Western Ontario, Canada.
FAU - Schmid, Susanne
AU  - Schmid S
AD  - Anatomy & Cell Biology, Schulich School of Medicine & Dentistry, The University 
      of Western Ontario, Canada.
LA  - eng
PT  - Journal Article
DEP - 20201008
PL  - United States
TA  - Brain Behav Immun Health
JT  - Brain, behavior, & immunity - health
JID - 101759062
PMC - PMC8474281
OTO - NOTNLM
OT  - Autism Spectrum Disorder
OT  - Habituation
OT  - Litter variability
OT  - Neurodevelopmental disorder
OT  - Poly I:C
OT  - Prepulse inhibition
OT  - Schizophrenia
OT  - Sensorimotor gating
OT  - Startle
COIS- The authors declare no conflicts of interest.
EDAT- 2021/10/01 06:00
MHDA- 2021/10/01 06:01
PMCR- 2020/10/08
CRDT- 2021/09/30 07:21
PHST- 2020/10/05 00:00 [received]
PHST- 2020/10/06 00:00 [accepted]
PHST- 2021/09/30 07:21 [entrez]
PHST- 2021/10/01 06:00 [pubmed]
PHST- 2021/10/01 06:01 [medline]
PHST- 2020/10/08 00:00 [pmc-release]
AID - S2666-3546(20)30121-6 [pii]
AID - 100156 [pii]
AID - 10.1016/j.bbih.2020.100156 [doi]
PST - epublish
SO  - Brain Behav Immun Health. 2020 Oct 8;9:100156. doi: 10.1016/j.bbih.2020.100156. 
      eCollection 2020 Dec.