PMID- 34590491
OWN - NLM
STAT- MEDLINE
DCOM- 20220812
LR  - 20220812
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 32
IP  - 5
DP  - 2022 Sep
TI  - Study of inner retinal neurodegeneration in Diabetes Mellitus using spectral 
      domain optical coherence tomography.
PG  - 3074-3081
LID - 10.1177/11206721211048793 [doi]
AB  - PURPOSE: To study inner retinal neurodegeneration in Diabetes Mellitus using 
      spectral domain optical coherence tomography (OCT). METHODS: This cross-sectional 
      study included 40 eyes of age matched healthy subjects (group N), 40 eyes of 
      diabetic patients without diabetic retinopathy (group D) and 160 eyes with 
      diabetic retinopathy (group R) having 40 each in subgroups R1 (mild), R2 
      (moderate), R3 (severe/very severe) non-proliferative stages and R4 
      (proliferative stage). Spectral domain OCT was used to measure the ganglion 
      cell-inner plexiform layer (GC-IPL) thickness and retinal nerve fibre layer 
      (RNFL) thickness. RESULTS: The average GC-IPL thickness was significantly lower, 
      both in groups D (p = 0.005) and R (p = 0.009), when compared with group N. The 
      minimum GC-IPL thickness was also significantly lower in groups D (p < 0.001) and 
      R (p < 0.001). There was no statistically significant difference in the average 
      RNFL thickness among the groups. The minimum RNFL thickness was significantly 
      lesser in group D (p = 0.027). The minimum RNFL thickness had a strongly negative 
      correlation with the severity of DR (R = -0.828; p = 0.042). The thinning of both 
      GC-IPL and RNFL was most pronounced in subgroup R4. CONCLUSION: There is a 
      significant reduction in the GC-IPL thickness and the RNFL thickness in diabetes 
      even before the onset of DR. The changes in both GC-IPL thickness and RNFL 
      thickness are most pronounced after the onset of PDR. There is a strongly 
      negative correlation between the minimum RNFL thickness with the severity of DR.
FAU - Ambiya, Vikas
AU  - Ambiya V
AUID- ORCID: 0000-0001-9439-2268
AD  - Command Hospital, Kolkata, India.
FAU - Kumar, Ashok
AU  - Kumar A
AUID- ORCID: 0000-0003-0853-3744
AD  - Armed Forces Medical College, Pune, India.
FAU - Bhavaraj, Veerabhadra Rao
AU  - Bhavaraj VR
AD  - Command Hospital, Kolkata, India.
FAU - Sharma, Vijay
AU  - Sharma V
AD  - Command Hospital, Kolkata, India.
FAU - Sharma, Neeraj
AU  - Sharma N
AD  - Command Hospital, Kolkata, India.
LA  - eng
PT  - Journal Article
DEP - 20210930
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
SB  - IM
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus
MH  - *Diabetic Retinopathy/diagnosis
MH  - Humans
MH  - Nerve Fibers
MH  - Retinal Ganglion Cells
MH  - Tomography, Optical Coherence/methods
OTO - NOTNLM
OT  - Diabetes Mellitus
OT  - GC-IPL
OT  - RNFL
OT  - diabetic retinopathy
EDAT- 2021/10/01 06:00
MHDA- 2022/08/13 06:00
CRDT- 2021/09/30 08:38
PHST- 2021/10/01 06:00 [pubmed]
PHST- 2022/08/13 06:00 [medline]
PHST- 2021/09/30 08:38 [entrez]
AID - 10.1177/11206721211048793 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2022 Sep;32(5):3074-3081. doi: 10.1177/11206721211048793. Epub 
      2021 Sep 30.