PMID- 34592305
OWN - NLM
STAT- MEDLINE
DCOM- 20220204
LR  - 20220204
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Linking)
VI  - 911
DP  - 2021 Nov 15
TI  - Ameliorative effect of myrcene in mouse model of Alzheimer's disease.
PG  - 174529
LID - S0014-2999(21)00685-3 [pii]
LID - 10.1016/j.ejphar.2021.174529 [doi]
AB  - Myrcene (Myr) has been reported to show neuroprotective effects in cerebral 
      ischemia. In this research work, we investigated the Myr effect on 
      neurobehavioural, and neuropathological alteration in mice induced by Aluminium 
      trichloride (AlCl(3)) and D - galactose. The administration of AlCl(3) (5 mg/kg; 
      p. o.), and D - galactose (60 mg/kg; i. p.) for 90 days in mice resulted in 
      spatial learning and memory deficits, cognitive decline, as well as 
      neurotoxicity. The treatments with Myr low dose (100 mg/kg), Myr high dose 
      (200 mg/kg), donepezil (2 mg/kg), and Myr low dose + donepezil (100 + 2 mg/kg) 
      were administered via intraperitoneal route for 30 days significantly reversed 
      the neurobehavioral, and neuropathological effects of AlCl(3) and D - galactose 
      in mice. The results of behavioural tests such as Morris water maze, elevated 
      plus maze, and locomotor; biochemical analysis such as malondialdehyde (MDA), 
      glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), nitrite, and 
      acetylcholinesterase (AChE); and ELISA tests such as mouse beta - secretase (BACE), 
      amyloid-beta peptide(1-42) (Abeta(1 - 42)), tumor necrosis factor - alpha (TNF-alpha), 
      interleukin - 6 (IL-6), and brain-derived neurotrophic factor (BDNF) demonstrated 
      a significant (p < 0.05) neuroprotective effect of the Myr and donepezil 
      co-treatments. In addition, hematoxylin and eosin staining of the cerebral cortex 
      and hippocampus revealed eosinophilic lesions and hyperchromatic nuclei in 
      Alzheimer's disease mice, but treatments with Myr low dose, Myr high dose, 
      donepezil, and Myr low dose + donepezil reversed these neurodegenerative effects. 
      Myr showed these activities by enhancing synaptic plasticity and cholinergic 
      activity, as well as reducing oxidative damage, neuroinflammation, Abeta(1-42) 
      aggregations, and histopathological damage. Myr alone and in combination with 
      donepezil may serve as a potential candidate for the treatment of Alzheimer's 
      disease.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Kumar, Rakesh
AU  - Kumar R
AD  - School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 
      144411, Punjab, India.
FAU - Kumar, Rajan
AU  - Kumar R
AD  - School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 
      144411, Punjab, India.
FAU - Sharma, Neha
AU  - Sharma N
AD  - School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 
      144411, Punjab, India.
FAU - Khurana, Navneet
AU  - Khurana N
AD  - School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 
      144411, Punjab, India. Electronic address: navi.pharmacist@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20210928
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
SB  - IM
MH  - *Alzheimer Disease
OTO - NOTNLM
OT  - Aluminium trichloride
OT  - Alzheimer's disease
OT  - D - galactose
OT  - Donepezil
OT  - Myrcene
OT  - Oxidative stress
EDAT- 2021/10/01 06:00
MHDA- 2022/02/05 06:00
CRDT- 2021/09/30 20:14
PHST- 2021/04/22 00:00 [received]
PHST- 2021/09/23 00:00 [revised]
PHST- 2021/09/24 00:00 [accepted]
PHST- 2021/10/01 06:00 [pubmed]
PHST- 2022/02/05 06:00 [medline]
PHST- 2021/09/30 20:14 [entrez]
AID - S0014-2999(21)00685-3 [pii]
AID - 10.1016/j.ejphar.2021.174529 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2021 Nov 15;911:174529. doi: 10.1016/j.ejphar.2021.174529. Epub 
      2021 Sep 28.