PMID- 34592520
OWN - NLM
STAT- MEDLINE
DCOM- 20211020
LR  - 20220531
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 226
DP  - 2021 Dec 15
TI  - The associations between urinary metals and metal mixtures and kidney function in 
      Chinese community-dwelling older adults with diabetes mellitus.
PG  - 112829
LID - S0147-6513(21)00941-6 [pii]
LID - 10.1016/j.ecoenv.2021.112829 [doi]
AB  - BACKGROUND: Previous studies have found associations between single toxic metals, 
      such as arsenic and cadmium, and kidney function in adults with diabetes. 
      However, studies with regards to other metals and metal mixtures are still 
      limited. OBJECTIVE: Our study aimed to investigate the associations between 
      urinary concentrations of 5 selected metals and metal mixtures and kidney 
      function using a sample of older adults with diabetes mellitus in Chinese 
      communities. METHODS: In a sample of older adults (n = 5186), 592 eligible 
      subjects were included in this study. Urinary concentrations of 5 metals, i.e., 
      arsenic (As), cadmium (Cd), vanadium (V), cobalt (Co), and thallium (Tl), were 
      measured by inductively coupled plasma mass spectrometer (ICP-MS). Estimated 
      glomerular filtration rate (eGFR) was calculated and dichotomized into indicator 
      of chronic kidney disease (CKD). Logistic analysis and Bayesian kernel machine 
      regression (BKMR) were used to explore the associations between single metals and 
      metal mixtures and CKD, respectively. RESULTS: Urinary levels of As and V were 
      positively correlated with CKD (OR=2.37, 95% CI: 1.31-4.30 for As; OR=2.24, 95% 
      CI: 1.25-4.03 for V), when compared the 4th quartile with the 1st quartile. After 
      adjustment for potential confounders, the significant association between As and 
      CKD still existed (OR=2.73, 95% CI: 1.23-6.07). BKMR analyses showed strong 
      linear positive associations between As and V and CKD. Higher urinary levels of 
      the mixture were significantly associated with higher odds of CKD in a 
      dose-response pattern. As and V showed the highest posterior inclusion 
      probabilities. CONCLUSION: Urine As and V were positively associated with CKD in 
      older adults with diabetes mellitus, separately and in a mixture. The metals 
      mixture showed a linear dose-response association with the odds of CKD. The 
      analyses of mixtures, rather than of single metals, may provide a real-world 
      perspective on the relationship between metals and kidney function.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Zhou, Ting-Ting
AU  - Zhou TT
AD  - School of Public Health, Department of Hygiene Inspection and Quarantine, Anhui 
      Medical University, Hefei, Anhui 230032, China.
FAU - Hu, Bing
AU  - Hu B
AD  - Fuyang Center for Disease Control and Prevention, Fuyang, Anhui 236069, China.
FAU - Meng, Xiang-Long
AU  - Meng XL
AD  - School of Public Health, Department of Epidemiology and Health Statistics, Anhui 
      Medical University, Hefei, Anhui 230032, China.
FAU - Sun, Liang
AU  - Sun L
AD  - Fuyang Center for Disease Control and Prevention, Fuyang, Anhui 236069, China.
FAU - Li, Huai-Biao
AU  - Li HB
AD  - Fuyang Center for Disease Control and Prevention, Fuyang, Anhui 236069, China.
FAU - Xu, Pei-Ru
AU  - Xu PR
AD  - School of Public Health, Department of Epidemiology and Health Statistics, Anhui 
      Medical University, Hefei, Anhui 230032, China.
FAU - Cheng, Bei-Jing
AU  - Cheng BJ
AD  - School of Public Health, Department of Epidemiology and Health Statistics, Anhui 
      Medical University, Hefei, Anhui 230032, China.
FAU - Sheng, Jie
AU  - Sheng J
AD  - School of Public Health, Experimental Center for Public Health, Anhui Medical 
      University, Hefei, Anhui 230032, China.
FAU - Tao, Fang-Biao
AU  - Tao FB
AD  - School of Health Services Management, Anhui Medical University, Hefei, Anhui 
      230032, China; Anhui Provincial Key Laboratory of Population Health and 
      Aristogenics, Hefei, Anhui 230032, China.
FAU - Yang, Lin-Sheng
AU  - Yang LS
AD  - School of Public Health, Department of Epidemiology and Health Statistics, Anhui 
      Medical University, Hefei, Anhui 230032, China. Electronic address: 
      yanglinsheng@ahmu.edu.cn.
FAU - Wu, Qing-Si
AU  - Wu QS
AD  - School of Public Health, Department of Hygiene Inspection and Quarantine, Anhui 
      Medical University, Hefei, Anhui 230032, China; Department of Clinical 
      Laboratory, The Second People's Hospital of Hefei, Hefei, Anhui 230011, China. 
      Electronic address: wuqingsi@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210927
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Metals)
SB  - IM
MH  - Aged
MH  - Bayes Theorem
MH  - China
MH  - *Diabetes Mellitus/chemically induced
MH  - Humans
MH  - *Kidney
MH  - Metals/*urine
OTO - NOTNLM
OT  - Bayesian kernel machine regression (BKMR)
OT  - Chronic kidney disease
OT  - Diabetes mellitus
OT  - Metal mixtures
OT  - Older adults
EDAT- 2021/10/01 06:00
MHDA- 2021/10/21 06:00
CRDT- 2021/09/30 20:19
PHST- 2021/07/31 00:00 [received]
PHST- 2021/09/11 00:00 [revised]
PHST- 2021/09/22 00:00 [accepted]
PHST- 2021/10/01 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2021/09/30 20:19 [entrez]
AID - S0147-6513(21)00941-6 [pii]
AID - 10.1016/j.ecoenv.2021.112829 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2021 Dec 15;226:112829. doi: 
      10.1016/j.ecoenv.2021.112829. Epub 2021 Sep 27.