PMID- 34592870
OWN - NLM
STAT- MEDLINE
DCOM- 20220330
LR  - 20220401
IS  - 1938-2405 (Electronic)
IS  - 0191-3913 (Linking)
VI  - 59
IP  - 2
DP  - 2022 Mar-Apr
TI  - Results of Follow-up in Pediatric Keratoconus Treated With Intracorneal Ring 
      Segments Implantation Alone or in Combination With Corneal Cross-linking.
PG  - 118-127
LID - 10.3928/01913913-20210719-02 [doi]
AB  - PURPOSE: To report visual and topographic outcomes of pediatric keratoconus with 
      intracorneal ring segments (ICRS) implantation alone or in combination with 
      accelerated corneal cross-linking (A-CXL). METHODS: A descriptive, retrospective 
      observational study was performed. Medical records of patients younger than 18 
      years at Fundacion Oftalmologica Nacional in Bogota, Colombia, were reviewed. 
      Demographic data, follow-up time, preoperative and postoperative uncorrected 
      (UCVA) and best corrected (BCVA) visual acuity, manifest refraction, and 
      tomography were evaluated. SPSS software (version 22.0; SPSS, Inc) was used for 
      analysis. RESULTS: Twenty-six eyes of 19 patients with a mean age of 16.5 +/- 1.8 
      years were analyzed, and 16 were boys (84.2%). Median follow-up time was 39.6 
      months (inter-quartile range [IQR] = 30). Fifteen patients (78.9%) had a history 
      of allergic conjunctivitis. Sixteen eyes (61.5%) received ICRS implantation with 
      A-CXL and 10 eyes (38.4%) received ICRS implantation only. Global results 
      (including ICRS implantation with A-CXL and ICRS implantation only) were: (1) 
      median UCVA of 0.90 logarithm of the minimum angle of resolution (logMAR) (IQR = 
      0.85) preoperatively improved to 0.54 logMAR (IQR = 0.70) postoperatively; (2) 
      median BCVA of 0.43 logMAR (IQR = 0.39) preoperatively improved to 0.30 logMAR 
      (IQR = 0.26) postoperatively; and (3) median spherical equivalent of -5.37 
      diopters (D) (IQR = -5.28) preoperatively improved to -4.12 D (IQR = -3.57) 
      postoperatively. There was a reduction in half of the sphere and cylinder. The 
      median maximum keratometry was 54.40 D (IQR = 7.4) preoperatively and 49.80 D 
      (IQR = 5.3) postoperatively. The median asphericity was -1.18 (IQR = 0.70) 
      preoperatively and changed to -0.75 (IQR = 0.68) postoperatively. No patient 
      presented with complications before or after surgery. CONCLUSIONS: ICRS 
      implantation only or in combination with A-CXL induced visual and topographic 
      improvement in patients with keratoconus, which was maintained throughout the 
      follow-up time. It seems to be a safe procedure to delay or avoid corneal 
      transplantation in the pediatric population. [J Pediatr Ophthalmol Strabismus. 
      2022;59(2):118-127.].
FAU - Mendez, Emilio A
AU  - Mendez EA
FAU - Roys, Nilva
AU  - Roys N
FAU - Mejia, Maria Elisa
AU  - Mejia ME
FAU - Plata, Maria Camila
AU  - Plata MC
FAU - Rosenstiehl, Shirley M
AU  - Rosenstiehl SM
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210930
PL  - United States
TA  - J Pediatr Ophthalmol Strabismus
JT  - Journal of pediatric ophthalmology and strabismus
JID - 7901143
RN  - 0 (Cross-Linking Reagents)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Corneal Stroma/surgery
MH  - Corneal Topography
MH  - Cross-Linking Reagents/therapeutic use
MH  - Follow-Up Studies
MH  - Humans
MH  - *Keratoconus/diagnosis/surgery
MH  - Male
MH  - Prosthesis Implantation/methods
MH  - Refraction, Ocular
EDAT- 2021/10/02 06:00
MHDA- 2022/03/31 06:00
CRDT- 2021/10/01 05:37
PHST- 2021/10/02 06:00 [pubmed]
PHST- 2022/03/31 06:00 [medline]
PHST- 2021/10/01 05:37 [entrez]
AID - 10.3928/01913913-20210719-02 [doi]
PST - ppublish
SO  - J Pediatr Ophthalmol Strabismus. 2022 Mar-Apr;59(2):118-127. doi: 
      10.3928/01913913-20210719-02. Epub 2021 Sep 30.