PMID- 34593536 OWN - NLM STAT- MEDLINE DCOM- 20211221 LR - 20211221 IS - 1939-327X (Electronic) IS - 0012-1797 (Linking) VI - 70 IP - 10 DP - 2021 Oct TI - Perirenal Fat Thickness Is Significantly Associated With the Risk for Development of Chronic Kidney Disease in Patients With Diabetes. PG - 2322-2332 LID - 10.2337/db20-1031 [doi] AB - Perirenal fat is adjacent to kidneys and active in metabolism and adipokine secretion. We aimed to investigate whether perirenal fat is an independent predictor for chronic kidney disease (CKD) and compared it with total, subcutaneous, or visceral fat in patients with diabetes. Perirenal fat thickness (PRFT) was measured by computed tomography, and total body fat (TBF), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) were assessed by DEXA. In cross-sectional analysis, patients with higher PRFT had a lower estimated glomerular filtration rate (eGFR). Multiple linear regression analysis showed a negative correlation between PRFT and eGFR after confounders adjustment. No association between eGFR and TBF, SAT, or VAT was observed. Longitudinally, 190 patients with type 2 diabetes mellitus (T2DM) without CKD at baseline were followed for 2 years. A total of 29 participants developed CKD. After VAT-based multivariate adjustment, each SD (per-SD) increment in baseline PRFT was associated with a higher incidence of CKD (hazard ratio 1.67, 95% CI 1.04-2.68), while TBF, SAT, and VAT were not. Furthermore, PRFT predicted CKD, with a C-statistic (95% CI) of 0.668 (0.562, 0.774), which was higher than that of TPF [0.535 (0.433, 0.637)], SAT [0.526 (0.434, 0.618)], and VAT [0.602 (0.506, 0.698)]. In conclusion, with perirenal fat there was a higher predictive value for CKD than with total, subcutaneous, or visceral fat in T2DM. CI - (c) 2021 by the American Diabetes Association. FAU - Chen, Xiangjun AU - Chen X AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Mao, Yun AU - Mao Y AD - Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Hu, Jinbo AU - Hu J AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Han, Shichao AU - Han S AD - Department of Statistics, University of California, Berkeley, Berkeley, CA. FAU - Gong, Lilin AU - Gong L AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Luo, Ting AU - Luo T AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Yang, Shumin AU - Yang S AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Qing, Hua AU - Qing H AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Wang, Yue AU - Wang Y AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Du, Zhipeng AU - Du Z AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Mei, Mei AU - Mei M AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zheng, Li AU - Zheng L AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Lv, Xinlu AU - Lv X AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Tang, Ying AU - Tang Y AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhao, Qinying AU - Zhao Q AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhou, Yangmei AU - Zhou Y AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - He, John Cijiang AU - He JC AD - Department of Medicine/Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY. AD - Renal Section, James J. Peters Veterans Affairs Medical Center, Bronx, NY. FAU - Li, Qifu AU - Li Q AUID- ORCID: 0000-0001-7249-6445 AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China towzh713@126.com liqifu@yeah.net. FAU - Wang, Zhihong AU - Wang Z AUID- ORCID: 0000-0001-7249-6445 AD - Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China towzh713@126.com liqifu@yeah.net. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210622 PL - United States TA - Diabetes JT - Diabetes JID - 0372763 SB - IM CIN - Diabetes. 2021 Oct;70(10):2190-2191. PMID: 34593541 MH - Adiposity/*physiology MH - Aged MH - China MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/complications/diagnosis/metabolism MH - Diabetic Nephropathies/diagnosis/*etiology/metabolism MH - Female MH - Humans MH - Intra-Abdominal Fat/diagnostic imaging/metabolism/pathology MH - Kidney/diagnostic imaging/*metabolism/pathology MH - Male MH - Middle Aged MH - Organ Size MH - Renal Insufficiency, Chronic/diagnosis/*etiology/metabolism MH - Risk Factors MH - Tomography, X-Ray Computed EDAT- 2021/10/02 06:00 MHDA- 2021/12/22 06:00 CRDT- 2021/10/01 06:11 PHST- 2020/10/10 00:00 [received] PHST- 2021/06/14 00:00 [accepted] PHST- 2021/10/01 06:11 [entrez] PHST- 2021/10/02 06:00 [pubmed] PHST- 2021/12/22 06:00 [medline] AID - db20-1031 [pii] AID - 10.2337/db20-1031 [doi] PST - ppublish SO - Diabetes. 2021 Oct;70(10):2322-2332. doi: 10.2337/db20-1031. Epub 2021 Jun 22.