PMID- 34596578
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211203
IS  - 2049-3614 (Print)
IS  - 2049-3614 (Electronic)
IS  - 2049-3614 (Linking)
VI  - 10
IP  - 11
DP  - 2021 Nov 3
TI  - Relationship of microRNA locus with type 2 diabetes mellitus: a case-control 
      study.
PG  - 1393-1402
LID - 10.1530/EC-21-0261 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is considered as a metabolic disease with 
      hyperglycemia. Accumulating investigations have explored the important role of 
      hereditary factors for T2DM occurrence. Some functional microRNA (miR) 
      polymorphisms may affect their interactions with target mRNAs and result in an 
      aberrant expression. Thus, miR variants might be considered as a biomarker of the 
      susceptibility of T2DM. In this study, we recruited 502 T2DM cases and 782 
      healthy subjects. We selected miR-146a rs2910164 C>G, miR-196a2 rs11614913 T>C 
      and miR-499 rs3746444 A>G loci and carried out an investigation to identify 
      whether these miR loci could influence T2DM occurrence. In this investigation, a 
      Bonferroni correction was harnessed. After adjustment, we found that rs2910164 
      SNP was a protective factor for T2DM (GG vs CC/CG: adjusted P = 0.010), 
      especially in never drinking (GG vs CC/CG: adjusted P = 0.001) and BMI >/=24 kg/m2 
      (GG vs CC/CG: adjusted P = 0.002) subgroups. We also identified that rs11614913 
      SNP was a protective factor for T2DM in smoking subjects (CC/TC vs TT: adjusted P 
      = 0.002). When we analyzed an interaction of SNP-SNP with the susceptibility tof 
      T2DM, rs11614913/rs3746444, rs2910164/rs3746444 and rs11614913/rs2910164 
      combinations were not associated with the risk of T2DM. In summary, this study 
      highlights that rs2910164 SNP decreases the susceptibility of T2DM, especially in 
      BMI >/=24 kg/m2 and never drinking subgroups. In addition, we also identify that 
      rs11614913 C allele decreases the susceptibility of T2DM significantly in smoking 
      subgroup.
FAU - Huang, Qiuyu
AU  - Huang Q
AD  - Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, 
      Fuzhou, Fujian Province, China.
AD  - Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian 
      Province University, Fuzhou, Fujian Province, China.
FAU - Chen, Hanshen
AU  - Chen H
AD  - Department of Anesthesiology, The First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, Fujian Province, China.
FAU - Xu, Fan
AU  - Xu F
AD  - Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, 
      Fuzhou, Fujian Province, China.
AD  - Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian 
      Province University, Fuzhou, Fujian Province, China.
FAU - Liu, Chao
AU  - Liu C
AD  - Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu 
      University, Zhenjiang, Jiangsu Province, China.
FAU - Wang, Yafeng
AU  - Wang Y
AD  - Department of Cardiology, The People's Hospital of Xishuangbanna Dai Autonomous 
      Prefecture, Jinghong, Yunnan Province, China.
FAU - Tang, Weifeng
AU  - Tang W
AD  - Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Nanjing 
      University Medical School, Jiangsu Province, China.
FAU - Chen, Liangwan
AU  - Chen L
AD  - Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, 
      Fuzhou, Fujian Province, China.
AD  - Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian 
      Province University, Fuzhou, Fujian Province, China.
LA  - eng
PT  - Journal Article
DEP - 20211103
PL  - England
TA  - Endocr Connect
JT  - Endocrine connections
JID - 101598413
PMC - PMC8630770
OTO - NOTNLM
OT  - microRNA
OT  - polymorphism
OT  - risk
OT  - type 2 diabetes mellitus
EDAT- 2021/10/02 06:00
MHDA- 2021/10/02 06:01
PMCR- 2021/09/30
CRDT- 2021/10/01 12:20
PHST- 2021/08/30 00:00 [received]
PHST- 2021/09/30 00:00 [accepted]
PHST- 2021/10/02 06:00 [pubmed]
PHST- 2021/10/02 06:01 [medline]
PHST- 2021/10/01 12:20 [entrez]
PHST- 2021/09/30 00:00 [pmc-release]
AID - EC-21-0261.R1 [pii]
AID - EC-21-0261 [pii]
AID - 10.1530/EC-21-0261 [doi]
PST - epublish
SO  - Endocr Connect. 2021 Nov 3;10(11):1393-1402. doi: 10.1530/EC-21-0261.