PMID- 34596802
OWN - NLM
STAT- MEDLINE
DCOM- 20220127
LR  - 20220127
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 28
IP  - 2
DP  - 2022 Feb
TI  - Which Is Safer, Chinese Medicine or Western Medicine? Comparative Analysis Based 
      on Chinese Spontaneous Reporting Database.
PG  - 138-144
LID - 10.1007/s11655-021-3340-7 [doi]
AB  - OBJECTIVE: To compare the safety differences between Chinese medicine (CM) and 
      Western medicine (WM) based on Chinese Spontaneous Reporting Database (CSRD). 
      METHODS: Reports of adverse events (AEs) caused by CM and WM in the CSRD between 
      2010 and 2011 were selected. The following assessment indicators were 
      constructed: the proportion of serious AEs (PSE), the average number of AEs 
      (ANA), and the coverage rate of AEs (CRA). Further comparisons were also 
      conducted, including the drugs with the most reported serious AEs, the AEs with 
      the biggest report number, and the 5 serious AEs of interest (including death, 
      anaphylactic shock, coma, dyspnea and abnormal liver function). RESULTS: The PSE, 
      ANA and CRA of WM were 1.09, 8.23 and 2.35 times higher than those of CM, 
      respectively. The top 10 drugs with the most serious AEs were mainly injections 
      for CM and antibiotics for WM. The AEs with the most reports were rash, pruritus, 
      nausea, dizziness and vomiting for both CM and WM. The proportions of CM and WM 
      in anaphylactic shock and coma were similar. For abnormal liver function and 
      death, the proportions of WM were 5.47 and 3.00 times higher than those of CM, 
      respectively. CONCLUSION: Based on CSRD, CM was safer than WM at the average 
      level from the perspective of adverse drug reactions.
CI  - (c) 2021. The Chinese Journal of Integrated Traditional and Western Medicine Press 
      and Springer-Verlag GmbH Germany, part of Springer Nature.
FAU - Wei, Jian-Xiang
AU  - Wei JX
AD  - School of Management, Nanjing University of Posts and Telecommunications, 
      Nanjing, 210003, China. jxwei@njupt.edu.cn.
FAU - Lu, Zhi-Qiang
AU  - Lu ZQ
AD  - School of Internet of Things, Nanjing University of Posts and Telecommunications, 
      Nanjing, 210003, China.
FAU - Feng, Guan-Zhong
AU  - Feng GZ
AD  - School of Internet of Things, Nanjing University of Posts and Telecommunications, 
      Nanjing, 210003, China.
FAU - Zhu, Yun-Xia
AU  - Zhu YX
AD  - School of Internet of Things, Nanjing University of Posts and Telecommunications, 
      Nanjing, 210003, China.
LA  - eng
PT  - Journal Article
DEP - 20211001
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
SB  - IM
MH  - China
MH  - *Drug-Related Side Effects and Adverse Reactions/epidemiology
MH  - Humans
MH  - Injections
MH  - *Medicine, Chinese Traditional
OTO - NOTNLM
OT  - Chinese medicine
OT  - Western medicine
OT  - adverse drug reaction
OT  - data analysis
OT  - drug safety
EDAT- 2021/10/02 06:00
MHDA- 2022/01/28 06:00
CRDT- 2021/10/01 12:28
PHST- 2021/01/08 00:00 [accepted]
PHST- 2021/10/02 06:00 [pubmed]
PHST- 2022/01/28 06:00 [medline]
PHST- 2021/10/01 12:28 [entrez]
AID - 10.1007/s11655-021-3340-7 [pii]
AID - 10.1007/s11655-021-3340-7 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2022 Feb;28(2):138-144. doi: 10.1007/s11655-021-3340-7. Epub 
      2021 Oct 1.