PMID- 34596873
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 72
IP  - 3
DP  - 2022 Mar
TI  - Distribution of HLA Alleles and Genotypes in Patients with Chronic Inflammatory 
      Demyelinating Polyneuropathy.
PG  - 574-584
LID - 10.1007/s12031-021-01902-x [doi]
AB  - Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired 
      immunological disorder. Although the precise pathoetiology of CIDP has not been 
      clarified yet, it is believed that both B and T cells of immune system contribute 
      in this disorder. Based on the importance of human leukocyte antigen (HLA) 
      cluster in the regulation of immune responses, this family of proteins is 
      putative determinants of risk of CIDP. We conducted the current investigation to 
      appraise association between HLA alleles/genotypes/haplotypes and risk of CIDP in 
      Iranian patients. HLA-DQB1*02 allele was significantly more prevalent among cases 
      compared with controls (OR [95% CI] = 4.82 [2.06, 11.3], P value = 0.000215, 
      adjusted P value = 0.0124). A*01-B*52-C*12-DRB1*15-DQB1*02 and 
      A*23-B*35-C*04-DRB1*11-DQB1*03 haplotypes with frequency of 0.03 were the most 
      frequent HLA haplotypes. These haplotypes were not detected among healthy 
      controls. The present study introduces HLA-DQB1*02 allele as a risk allele for 
      CIDP among Iranian patients and further supports the importance of HLA region in 
      this immunological condition.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Ghafouri-Fard, Soudeh
AU  - Ghafouri-Fard S
AD  - Department of Medical Genetics, School of Medicine, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran.
FAU - Akbari, Mohammad Taghi
AU  - Akbari MT
AD  - Tehran Medical Genetics Laboratory, Tehran, Iran.
FAU - Houlden, Henry
AU  - Houlden H
AD  - Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
FAU - Mazdeh, Mehrdokht
AU  - Mazdeh M
AD  - Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, 
      Iran.
FAU - Nazer, Naghme
AU  - Nazer N
AD  - Department of Electrical Engineering, Sharif University of Technology, Tehran, 
      Iran.
FAU - Rezaei, Omidvar
AU  - Rezaei O
AD  - Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran.
FAU - Taheri, Mohammad
AU  - Taheri M
AUID- ORCID: 0000-0001-8381-0591
AD  - Urology and Nephrology Research Center, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran. Mohammad_823@yahoo.com.
FAU - Sayad, Arezou
AU  - Sayad A
AD  - Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran. ar.sayad@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20211001
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DRB1 Chains/genetics
MH  - Haplotypes
MH  - Humans
MH  - Iran
MH  - *Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/genetics
OTO - NOTNLM
OT  - CIDP
OT  - Chronic inflammatory demyelinating polyneuropathy
OT  - HLA
EDAT- 2021/10/02 06:00
MHDA- 2022/04/05 06:00
CRDT- 2021/10/01 12:31
PHST- 2021/08/02 00:00 [received]
PHST- 2021/08/14 00:00 [accepted]
PHST- 2021/10/02 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/10/01 12:31 [entrez]
AID - 10.1007/s12031-021-01902-x [pii]
AID - 10.1007/s12031-021-01902-x [doi]
PST - ppublish
SO  - J Mol Neurosci. 2022 Mar;72(3):574-584. doi: 10.1007/s12031-021-01902-x. Epub 
      2021 Oct 1.