PMID- 34598908 OWN - NLM STAT- MEDLINE DCOM- 20220407 LR - 20220407 IS - 2152-2669 (Electronic) IS - 2152-2669 (Linking) VI - 22 IP - 2 DP - 2022 Feb TI - Favorable Long-Term Outcomes with Autologous Stem Cell Transplantation for High-Risk Multiple Myeloma Patients with a Positive Result On (18)F-FDG PET/CT at Baseline. PG - 113-120 LID - S2152-2650(21)02014-0 [pii] LID - 10.1016/j.clml.2021.08.012 [doi] AB - BACKGROUND: 18F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) is a useful tool for identifying high-risk features in patients with newly diagnosed multiple myeloma (NDMM). This study evaluated the role of autologous stem cell transplantation (ASCT) in patients presenting with positive results on PET/CT scans. MATERIALS AND METHODS: The medical records of 210 patients who underwent PET/CT at diagnosis were retrospectively reviewed. Eligible patients for transplantation proceeded to upfront ASCT with high-dose chemotherapy (HDT) after induction therapy with novel agents. RESULTS: The presence of a number of focal lesions (FL) >3 and extramedullary disease (EMD) occurred in 111 and 35 patients, respectively. ASCT was performed in 54 patients. Among patients with FL > 3, those treated with ASCT showed a prolonged 2-year progression-free survival (PFS) and overall survival (OS) rates compared to those not treated with ASCT (PFS, 60.2% vs. 23.5%, P < 0.001; OS, 91.7% vs. 63.6%, P = 0.005). In patients with FL 3, Revised International Staging System (R-ISS), and upfront ASCT were independent prognostic factors for PFS and OS. CONCLUSION: Presenting FL > 3 on baseline PET/CT represents a high-risk feature in patients with NDMM. Frontline ASCT with HDT prolonged the survival of patients with FL > 3. CI - Copyright (c) 2021 Elsevier Inc. All rights reserved. FAU - Cho, Hee Jeong AU - Cho HJ AD - Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea. FAU - Baek, Dong Won AU - Baek DW AD - Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea. FAU - Kim, Ju-Hyung AU - Kim JH AD - Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea. FAU - Lee, Jungmin AU - Lee J AD - Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea. FAU - Chung, Yu Kyung AU - Chung YK AD - Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea. FAU - Jung, Sung-Hoon AU - Jung SH AD - Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo, South Korea. FAU - Song, Ga-Young AU - Song GY AD - Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo, South Korea. FAU - Ahn, Seo-Yeon AU - Ahn SY AD - Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo, South Korea. FAU - Ahn, Jae-Sook AU - Ahn JS AD - Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo, South Korea. FAU - Yang, Deok-Hwan AU - Yang DH AD - Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo, South Korea. FAU - Lee, Je-Jung AU - Lee JJ AD - Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo, South Korea. FAU - Kim, Hyeoung-Joon AU - Kim HJ AD - Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo, South Korea. FAU - Hong, Chae Moon AU - Hong CM AD - Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea. FAU - Jeong, Shin Young AU - Jeong SY AD - Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea. FAU - Min, Jung-Joon AU - Min JJ AD - Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun, South Korea. FAU - Sohn, Sang-Kyun AU - Sohn SK AD - Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea. FAU - Moon, Joon Ho AU - Moon JH AD - Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea. Electronic address: jhmoon@knu.ac.kr. LA - eng PT - Journal Article DEP - 20210831 PL - United States TA - Clin Lymphoma Myeloma Leuk JT - Clinical lymphoma, myeloma & leukemia JID - 101525386 RN - 0Z5B2CJX4D (Fluorodeoxyglucose F18) SB - IM MH - Antineoplastic Combined Chemotherapy Protocols/therapeutic use MH - Fluorodeoxyglucose F18 MH - *Hematopoietic Stem Cell Transplantation/methods MH - Humans MH - *Multiple Myeloma/diagnostic imaging/therapy MH - Positron Emission Tomography Computed Tomography/methods MH - Prognosis MH - Retrospective Studies MH - Stem Cell Transplantation MH - Transplantation, Autologous OTO - NOTNLM OT - 18F-FDG PET/CT OT - Autologous stem cell transplantation OT - Focal lesions OT - Long-term outcomes OT - Newly diagnosed multiple myeloma EDAT- 2021/10/03 06:00 MHDA- 2022/04/08 06:00 CRDT- 2021/10/02 05:32 PHST- 2021/03/05 00:00 [received] PHST- 2021/07/12 00:00 [revised] PHST- 2021/08/26 00:00 [accepted] PHST- 2021/10/03 06:00 [pubmed] PHST- 2022/04/08 06:00 [medline] PHST- 2021/10/02 05:32 [entrez] AID - S2152-2650(21)02014-0 [pii] AID - 10.1016/j.clml.2021.08.012 [doi] PST - ppublish SO - Clin Lymphoma Myeloma Leuk. 2022 Feb;22(2):113-120. doi: 10.1016/j.clml.2021.08.012. Epub 2021 Aug 31.