PMID- 34601115
OWN - NLM
STAT- MEDLINE
DCOM- 20220111
LR  - 20220111
IS  - 1530-891X (Print)
IS  - 1530-891X (Linking)
VI  - 28
IP  - 1
DP  - 2022 Jan
TI  - Comparison of Profile of Primary Hyperparathyroidism With and Without Type 2 
      Diabetes Mellitus: Retrospective Analysis From the Indian Primary 
      Hyperparathyroidism Registry.
PG  - 96-101
LID - S1530-891X(21)01243-X [pii]
LID - 10.1016/j.eprac.2021.09.012 [doi]
AB  - OBJECTIVE: To describe the prevalence and compare the clinicobiochemical profile 
      of patients with primary hyperparathyroidism (PHPT) with and without type 2 
      diabetes mellitus (T2DM). METHODS: We conducted a retrospective observational 
      study wherein the details of patients with PHPT with T2DM (PHPT-T2DM) and without 
      T2DM were retrieved from the Indian PHPT Registry (www.indianphptregistry.com) 
      between 2005 and 2019. We compared the clinical, biochemical, and postoperative 
      findings of patients with PHPT-T2DM with age-, sex-, and body mass index-matched 
      patients with PHPT without T2DM (in 1:2 ratio). RESULTS: Of the 464 patients with 
      PHPT, 54 (11.6%) had T2DM. We observed an increase in the prevalence of PHPT-T2DM 
      cases over time; only 7 (7.1%) of the total patients with PHPT had T2DM between 
      2005 and 2009 that increased to 31 (12.8%) in the last half decade (2015-2019). 
      Patients with PHPT-T2DM had a significantly lower prevalence of nephrolithiasis 
      (18.5% vs 36.1%, respectively; P = .03) and a higher prevalence of pancreatitis 
      (22.2% vs 5.6%, respectively; P = .007) than those without T2DM. Furthermore, 
      intact parathyroid hormone (203 pg/mL [139.8-437.3 pg/mL] vs 285 pg/mL [166-692 
      pg/mL], respectively; P = .04) and serum creatinine (0.90 mg/dL [0.67-1.25 mg/dL] 
      vs 1.10 mg/dL [0.73-1.68 mg/dL], respectively; P = .03) levels were significantly 
      lower in patients with PHPT-T2DM than those without T2DM. Also, tumor weight 
      tended to be lower in patients with PHPT-T2DM than in the non-T2DM counterparts 
      (1.05 g [0.5-2.93 g] vs 2.16 g [0.81-7.0 g], respectively; P = .06). CONCLUSION: 
      The prevalence of T2DM in Asian Indians with PHPT is 11.6%. Patients with 
      PHPT-T2DM are characterized by a higher prevalence of pancreatitis, a lower 
      prevalence of nephrolithiasis, and lower levels of intact parathyroid 
      hormone/creatinine. Part of the clinical picture can possibly be explained by 
      early detection of PHPT in patients with T2DM consequent to more frequent 
      screening.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Kumari, Poonam
AU  - Kumari P
AD  - Department of Endocrinology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Arya, Ashutosh Kumar
AU  - Arya AK
AD  - Department of Endocrinology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Pal, Rimesh
AU  - Pal R
AD  - Department of Endocrinology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Sood, Ashwani
AU  - Sood A
AD  - Department of Nuclear Medicine, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Dahiya, Divya
AU  - Dahiya D
AD  - Department of General Surgery, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Mukherjee, Soham
AU  - Mukherjee S
AD  - Department of Endocrinology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Rastogi, Ashu
AU  - Rastogi A
AD  - Department of Endocrinology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Bhadada, Sanjay Kumar
AU  - Bhadada SK
AD  - Department of Endocrinology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India. Electronic address: bhadadask@rediffmail.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210930
PL  - United States
TA  - Endocr Pract
JT  - Endocrine practice : official journal of the American College of Endocrinology 
      and the American Association of Clinical Endocrinologists
JID - 9607439
RN  - 0 (Parathyroid Hormone)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Calcium
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Humans
MH  - *Hyperparathyroidism, Primary/complications/epidemiology
MH  - Parathyroid Hormone
MH  - Registries
MH  - Retrospective Studies
OTO - NOTNLM
OT  - body mass index
OT  - hypercalcemia
OT  - primary hyperparathyroidism
OT  - type 2 diabetes
EDAT- 2021/10/04 06:00
MHDA- 2022/01/12 06:00
CRDT- 2021/10/03 20:42
PHST- 2021/06/17 00:00 [received]
PHST- 2021/09/17 00:00 [revised]
PHST- 2021/09/27 00:00 [accepted]
PHST- 2021/10/04 06:00 [pubmed]
PHST- 2022/01/12 06:00 [medline]
PHST- 2021/10/03 20:42 [entrez]
AID - S1530-891X(21)01243-X [pii]
AID - 10.1016/j.eprac.2021.09.012 [doi]
PST - ppublish
SO  - Endocr Pract. 2022 Jan;28(1):96-101. doi: 10.1016/j.eprac.2021.09.012. Epub 2021 
      Sep 30.