PMID- 34601357
OWN - NLM
STAT- MEDLINE
DCOM- 20211116
LR  - 20211116
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 430
DP  - 2021 Nov 15
TI  - Frontal lobe dysfunction is associated with reduced DAT-SPECT accumulation in 
      Lewy body disease.
PG  - 119998
LID - S0022-510X(21)02694-0 [pii]
LID - 10.1016/j.jns.2021.119998 [doi]
AB  - INTRODUCTION: Lewy body disease (LBD) causes olfactory or cognitive dysfunction 
      even before motor symptoms emerge. Recent reports indicate that the dopamine 
      transporter (DAT), which can be imaged using single-photon emission computed 
      tomography ((123)I-ioflupane SPECT), is related to olfactory and cognitive 
      dysfunction in LBD patients. We suspected that decreased cerebral blood flow 
      (CBF) in the frontal lobe might be involved in these relationships. If so, then 
      the results of these examinations may be useful in assessing the pathological 
      progression of Lewy bodies. METHODS: We retrospectively analyzed the data of 139 
      de novo consecutive patients with LBD. We used the Odor Stick Identification Test 
      for Japanese (OSIT-J) and the Frontal Assessment Battery (FAB) to evaluate 
      olfactory and frontal lobe dysfunction, respectively. Among the 139 patients, 
      ultimately 84 patients were analyzed and underwent (123)I-ioflupane SPECT within 
      3 months (before or after) of the OSIT-J and FAB. We categorized patients on the 
      basis of whether frontal lobe CBF was reduced (n = 28) or normal (n = 56). 
      RESULTS: The average OSIT-J and FAB scores were 4.0 and 14.1, respectively, and 
      the scores on the two tests were significantly correlated. Furthermore, OSIT-J 
      scores were significantly correlated with the specific binding ratio (SBR) in 
      both groups. The SBR was correlated with FAB scores in patients with reduced CBF 
      in the frontal lobe, but not in those with normal CBF. CONCLUSION: Frontal lobe 
      dysfunction and striatum dysfunction are correlated in LBD patients only after 
      CBF has declined. Also, there is a time lag in the appearance of olfactory 
      dysfunction and frontal lobe dysfunction in LBD patients. As with pathological 
      development, olfaction is impaired earliest, followed by striatal, and then 
      frontal lobe dysfunction.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Nakahara, Atsuo
AU  - Nakahara A
AD  - Department of Neurology, Daisan Hospital, The Jikei University School of 
      Medicine, Tokyo, Japan; Department of Neurology, The Jikei University School of 
      Medicine, Tokyo, Japan.
FAU - Sengoku, Renpei
AU  - Sengoku R
AD  - Department of Neurology, Daisan Hospital, The Jikei University School of 
      Medicine, Tokyo, Japan; Department of Neurology, The Jikei University School of 
      Medicine, Tokyo, Japan. Electronic address: renpei@jikei.ac.jp.
FAU - Umehara, Tadashi
AU  - Umehara T
AD  - Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Matsuno, Hiromasa
AU  - Matsuno H
AD  - Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Yamazaki, Mikihiro
AU  - Yamazaki M
AD  - Department of Neurology, Daisan Hospital, The Jikei University School of 
      Medicine, Tokyo, Japan; Department of Neurology, The Jikei University School of 
      Medicine, Tokyo, Japan.
FAU - Oka, Hisayoshi
AU  - Oka H
AD  - Department of Neurology, Daisan Hospital, The Jikei University School of 
      Medicine, Tokyo, Japan; Department of Neurology, The Jikei University School of 
      Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210921
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
SB  - IM
MH  - Dopamine Plasma Membrane Transport Proteins/metabolism
MH  - Frontal Lobe/diagnostic imaging/metabolism
MH  - Humans
MH  - *Lewy Body Disease/diagnostic imaging
MH  - Retrospective Studies
MH  - Tomography, Emission-Computed, Single-Photon
OTO - NOTNLM
OT  - Cerebral blood flow
OT  - Dopamine transporter SPECT
OT  - Frontal lobe function
OT  - Lewy body disease
OT  - Olfaction
EDAT- 2021/10/04 06:00
MHDA- 2021/11/17 06:00
CRDT- 2021/10/03 20:54
PHST- 2021/06/07 00:00 [received]
PHST- 2021/09/04 00:00 [revised]
PHST- 2021/09/17 00:00 [accepted]
PHST- 2021/10/04 06:00 [pubmed]
PHST- 2021/11/17 06:00 [medline]
PHST- 2021/10/03 20:54 [entrez]
AID - S0022-510X(21)02694-0 [pii]
AID - 10.1016/j.jns.2021.119998 [doi]
PST - ppublish
SO  - J Neurol Sci. 2021 Nov 15;430:119998. doi: 10.1016/j.jns.2021.119998. Epub 2021 
      Sep 21.