PMID- 34603198 OWN - NLM STAT- MEDLINE DCOM- 20220215 LR - 20240403 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 12 DP - 2021 TI - Association of ANGPTL8 and Resistin With Diabetic Nephropathy in Type 2 Diabetes Mellitus. PG - 695750 LID - 10.3389/fendo.2021.695750 [doi] LID - 695750 AB - BACKGROUND: Previous studies showed altered angiopoietin-like protein-8 (ANGPTL-8) and resistin circulating levels in type 2 diabetes mellitus (T2DM). Whether or not the alteration in ANGPTL-8 and resistin level can be a predictive maker for increased diabetic nephropathy risk remains unclear. AIM: To Investigate the possible association of ANGPTL-8 and resistin with DN, and whether this association is affected by NAFLD status. METHODS: A total of 278 T2DM patients were enrolled. Serum levels of ANGPTL8, resistin, BMI, blood pressure, duration of diabetes, glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG), hypersensitive C-reactive protein (hs-CRP), lipid profile, liver, and kidney function tests were assessed. The relationship between DN with ANGPTL8 and resistin was analyzed in the unadjusted and multiple-adjusted regression models. RESULTS: Serum levels of ANGPTL8 and resistin were significantly higher in DN compared with T2DM subjects without DN (respectively; P <0.001), especially in non-NAFLD populations. ANGPTL8 and resistin showed positive correlation with hs-CRP (respectively; P<0.01), and negative correlation with estimated GFR (eGFR) (respectively; P=<0.001) but no significant correlation to HOMA-IR(respectively; P>0.05). Analysis showed ANGPTL8 levels were positively associated with resistin but only in T2DM patients with DN(r=0.1867; P<0.05), and this significant correlation disappeared in T2DM patients without DN. After adjusting for confounding factors, both ANGPTL8(OR=2.095, 95%CI 1.253-3.502 P=0.005) and resistin (OR=2.499, 95%CI 1.484-4.208 P=0.001) were risk factors for DN. Data in non-NAFLD population increased the relationship between ANGPTL8 (OR=2.713, 95% CI 1.494-4.926 P=0.001), resistin (OR=4.248, 95% CI 2.260-7.987 P<0.001)and DN. The area under the curve (AUC) on receiver operating characteristic (ROC) analysis of the combination of ANGPTL8 and resistin was 0.703, and the specificity was 70.4%. These data were also increased in non-NAFLD population, as the AUC (95%CI) was 0.756, and the specificity was 91.2%. CONCLUSION: This study highlights a close association between ANGPTL8, resistin and DN, especially in non-NAFLD populations. These results suggest that ANGPTL-8 and resistin may be risk predictors of DN. CI - Copyright (c) 2021 Li, Fan, Peng, Huang, Zou, Yu, Yang, Shi and Ma. FAU - Li, Mengni AU - Li M AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Fan, Rongping AU - Fan R AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Peng, Xuemin AU - Peng X AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Huang, Jiaojiao AU - Huang J AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Zou, Huajie AU - Zou H AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Yu, Xuefeng AU - Yu X AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. AD - Wuhan Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, China. FAU - Yang, Yan AU - Yang Y AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. AD - Wuhan Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, China. FAU - Shi, Xiaoli AU - Shi X AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. AD - Wuhan Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, China. FAU - Ma, DeLin AU - Ma D AD - Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. AD - Wuhan Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210915 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (ANGPTL8 protein, human) RN - 0 (Angiopoietin-Like Protein 8) RN - 0 (Biomarkers) RN - 0 (Glycated Hemoglobin A) RN - 0 (Peptide Hormones) RN - 0 (RETN protein, human) RN - 0 (Resistin) SB - IM MH - Adult MH - Aged MH - Angiopoietin-Like Protein 8/*blood MH - Biomarkers/blood MH - Case-Control Studies MH - China MH - Diabetes Mellitus, Type 2/*blood/complications MH - Diabetic Nephropathies/*blood/diagnosis MH - Female MH - Glycated Hemoglobin/metabolism MH - Humans MH - Male MH - Middle Aged MH - Non-alcoholic Fatty Liver Disease/blood/complications MH - Peptide Hormones/*blood MH - Prognosis MH - Resistin/*blood MH - Risk Factors PMC - PMC8479106 OTO - NOTNLM OT - ANGPTL-8 OT - diabetic nephropathy OT - non-alcoholic fatty liver OT - predictive effect OT - resistin OT - type 2 diabetes mellitus COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/10/05 06:00 MHDA- 2022/02/16 06:00 PMCR- 2021/01/01 CRDT- 2021/10/04 05:57 PHST- 2021/04/15 00:00 [received] PHST- 2021/08/30 00:00 [accepted] PHST- 2021/10/04 05:57 [entrez] PHST- 2021/10/05 06:00 [pubmed] PHST- 2022/02/16 06:00 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2021.695750 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2021 Sep 15;12:695750. doi: 10.3389/fendo.2021.695750. eCollection 2021.