PMID- 34603985
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220427
IS  - 2223-4292 (Print)
IS  - 2223-4306 (Electronic)
IS  - 2223-4306 (Linking)
VI  - 11
IP  - 10
DP  - 2021 Oct
TI  - Comparison between tumour metabolism derived from (18)F-FDG PET/CT and accurate 
      cytogenetic stratification in newly diagnosed multiple myeloma patients.
PG  - 4299-4309
LID - 10.21037/qims-21-85 [doi]
AB  - BACKGROUND: (18)F-fluorodeoxyglucose positron emission tomography integrated with 
      computed tomography ((18)F-FDG PET/CT) is a useful tool for baseline staging in 
      newly diagnosed multiple myeloma (MM) but also for prognostic stratification. 
      This monocentric retrospective study aimed at examining the relation between 
      baseline tumour metabolism assessed by (18)F-FDG PET/CT and linear predictor (LP) 
      score, a new cytogenetic stratification score. METHODS: From March 2012 to March 
      2019, 57 patients with newly diagnosed MM addressed to our institution for 
      baseline (18)F-FDG PET/CT were included. LP score was determined on systematic 
      iliac crest bone marrow samples. Obtained on CD138-sorted bone marrow plasma 
      cells, this recent composite cytogenetic stratification is a 6-marker based 
      weighted score using fluorescence in situ hybridization (FISH) +/- single 
      nucleotide polymorphism (SNP) arrays. We compared quantitative metabolic 
      parameters and LP score using a Kruskal-Wallis test and visual suspicion of 
      diffuse bone marrow involvement (DBI; based on hepatic background as threshold of 
      positivity) and cytogenetic data using a Chi-squared test. RESULTS: The 
      distribution of total metabolic tumour volume (TMTV) and total lesion glycolysis 
      (TLG) values among the three LP score categories was almost stochastic, with no 
      significant association (P=0.70). Additionally, no significant association 
      between TMTV/TLG and any of the six cytogenetic abnormalities included in LP 
      score calculation. A significant association was found between visual high 
      suspicion of DBI and LP score (P=0.036), and between this visual parameter and 
      the presence of 1q gain (P=0.049). CONCLUSIONS: There is no significant 
      association between quantitative metabolic parameters assessed with (18)F-FDG 
      PET/CT and LP score in patients with newly diagnosed MM, suggesting a potential 
      complementarity of these biomarkers for prognostic stratification. A significant 
      association was found between high visual suspicion of DBI and LP score.
CI  - 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
FAU - Silva, Yannick
AU  - Silva Y
AD  - Department of Nuclear Medicine, Unicancer-Georges Francois Leclerc Cancer Center, 
      Dijon, France.
FAU - Riedinger, Jean-Marc
AU  - Riedinger JM
AD  - Department of Nuclear Medicine, Unicancer-Georges Francois Leclerc Cancer Center, 
      Dijon, France.
FAU - Chretien, Marie-Lorraine
AU  - Chretien ML
AD  - Department of Clinical Haematology, Francois-Mitterrand University Hospital, 
      Dijon, France.
FAU - Caillot, Denis
AU  - Caillot D
AD  - Department of Clinical Haematology, Francois-Mitterrand University Hospital, 
      Dijon, France.
FAU - Corre, Jill
AU  - Corre J
AD  - Unit for Genomics in Myeloma, Institut Universitaire du Cancer-Oncopole, 
      Toulouse, France.
AD  - Centre de Recherches en Cancerologie de Toulouse, INSERMU1037, Toulouse, France.
FAU - Guillen, Kevin
AU  - Guillen K
AD  - Department of Diagnostic and Interventional Radiology, Francois-Mitterrand 
      University Hospital, Dijon, France.
FAU - Cochet, Alexandre
AU  - Cochet A
AD  - Department of Nuclear Medicine, Unicancer-Georges Francois Leclerc Cancer Center, 
      Dijon, France.
AD  - ImViA Laboratory-EA 7535, University of Bourgogne/Franche-Comte, Besancon, 
      France.
FAU - Tabouret-Viaud, Claire
AU  - Tabouret-Viaud C
AD  - Department of Nuclear Medicine, Unicancer-Georges Francois Leclerc Cancer Center, 
      Dijon, France.
FAU - Loffroy, Romaric
AU  - Loffroy R
AD  - Department of Diagnostic and Interventional Radiology, Francois-Mitterrand 
      University Hospital, Dijon, France.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Quant Imaging Med Surg
JT  - Quantitative imaging in medicine and surgery
JID - 101577942
PMC - PMC8408794
OTO - NOTNLM
OT  - 18F-fluorodeoxyglucose positron emission tomography integrated with computed 
      tomography (18F-FDG PET/CT)
OT  - Multiple myeloma (MM)
OT  - cytogenetic stratification
OT  - linear predictor score (LP score)
OT  - metabolic volume
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/qims-21-85). Dr. RL serves as an 
      unpaid deputy editor of Quantitative Imaging in Medicine and Surgery. AC serves 
      as an unpaid editorial board member of Quantitative Imaging in Medicine and 
      Surgery. The other authors have no conflicts of interest to declare.
EDAT- 2021/10/05 06:00
MHDA- 2021/10/05 06:01
PMCR- 2021/10/01
CRDT- 2021/10/04 06:07
PHST- 2021/01/22 00:00 [received]
PHST- 2021/05/14 00:00 [accepted]
PHST- 2021/10/04 06:07 [entrez]
PHST- 2021/10/05 06:00 [pubmed]
PHST- 2021/10/05 06:01 [medline]
PHST- 2021/10/01 00:00 [pmc-release]
AID - qims-11-10-4299 [pii]
AID - 10.21037/qims-21-85 [doi]
PST - ppublish
SO  - Quant Imaging Med Surg. 2021 Oct;11(10):4299-4309. doi: 10.21037/qims-21-85.