PMID- 34605949
OWN - NLM
STAT- MEDLINE
DCOM- 20220113
LR  - 20220113
IS  - 1432-0584 (Electronic)
IS  - 0939-5555 (Linking)
VI  - 101
IP  - 1
DP  - 2022 Jan
TI  - Characterization of molecular genetics and clinicopathology in thymic MALT 
      lymphoma.
PG  - 91-97
LID - 10.1007/s00277-021-04671-0 [doi]
AB  - Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue 
      (MALT) lymphoma is a type of low-grade malignant B-cell lymphoma. The aim of this 
      study was to investigate the clinicopathological characteristics of thymic MALT 
      lymphoma. We analyzed the clinical, morphological, immunophenotypical, 
      cytogenetic, and molecular characteristics of 11 cases of thymic MALT lymphoma. 
      The relevant literature was also reviewed. The median age of the 11 patients was 
      50 (range: 33-60). There was a female predominance with a female-to-male ratio of 
      10:1. Three patients presented with Sjogren syndrome, autoimmune thrombocytopenia 
      purpura, and type B1 thymoma, respectively. Microscopically, thymic MALT lymphoma 
      was characterized by epithelium-lined cysts that were surrounded by small 
      lymphocytes, centrocyte-like cells, and monocytoid B-cells. Plasmacytic 
      differentiation was observed in two cases. The tumor cells expressed CD20, CD79alpha, 
      and BCL2. Clonal immunoglobulin genes were detected in all 8 examined cases. 
      Fluorescence in situ hybridization (FISH) for 18q21 was performed in 7 cases, and 
      no translocations involving 18q21 were found. Targeted gene sequencing was 
      performed in five cases with available DNA samples, and TNFAIP3, CARD11, IGLL5, 
      and CCND3 mutations were identified. Thymic MALT lymphoma is a rare type of B 
      cell malignancy with a female predominance and excellent clinical outcomes. 
      Molecular aberrations involving the NF-kappaB pathway are frequent in thymic MALT 
      lymphoma, suggesting that dysregulation of the NF-kappaB pathway is an important 
      mechanism underlying the pathogenesis of thymic MALT lymphoma.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Wang, Xiaojun
AU  - Wang X
AD  - Department of Pathology, National Cancer Center/National Clinical Research Center 
      for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, 17 Panjiayuan Nan Li, Chaoyang District, Beijing, 100021, China.
FAU - Miao, Yi
AU  - Miao Y
AD  - Department of Hematology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital, Nanjing, China.
FAU - Cao, Zheng
AU  - Cao Z
AD  - Department of Pathology, National Cancer Center/National Clinical Research Center 
      for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, 17 Panjiayuan Nan Li, Chaoyang District, Beijing, 100021, China.
FAU - Zheng, Shan
AU  - Zheng S
AD  - Department of Pathology, National Cancer Center/National Clinical Research Center 
      for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, 17 Panjiayuan Nan Li, Chaoyang District, Beijing, 100021, China.
FAU - Xue, Xuemin
AU  - Xue X
AD  - Department of Pathology, National Cancer Center/National Clinical Research Center 
      for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, 17 Panjiayuan Nan Li, Chaoyang District, Beijing, 100021, China.
FAU - Feng, Xiaoli
AU  - Feng X
AD  - Department of Pathology, National Cancer Center/National Clinical Research Center 
      for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, 17 Panjiayuan Nan Li, Chaoyang District, Beijing, 100021, China. 
      fengxl@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20211004
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Rearrangement
MH  - High-Throughput Nucleotide Sequencing
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Mutation
MH  - Thymus Neoplasms/*genetics/pathology
MH  - Translocation, Genetic
OTO - NOTNLM
OT  - Autoimmune disease
OT  - Clonal gene rearrangement
OT  - Mucosa-associated lymphoid tissue
OT  - Mucosa-associated lymphoid tissue lymphoma
OT  - Thymic
EDAT- 2021/10/05 06:00
MHDA- 2022/01/14 06:00
CRDT- 2021/10/04 12:25
PHST- 2021/06/09 00:00 [received]
PHST- 2021/09/17 00:00 [accepted]
PHST- 2021/10/05 06:00 [pubmed]
PHST- 2022/01/14 06:00 [medline]
PHST- 2021/10/04 12:25 [entrez]
AID - 10.1007/s00277-021-04671-0 [pii]
AID - 10.1007/s00277-021-04671-0 [doi]
PST - ppublish
SO  - Ann Hematol. 2022 Jan;101(1):91-97. doi: 10.1007/s00277-021-04671-0. Epub 2021 
      Oct 4.