PMID- 34607255
OWN - NLM
STAT- MEDLINE
DCOM- 20220325
LR  - 20220325
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 238
DP  - 2021 Dec
TI  - Six months functional response to early psychosis intervention program best 
      predicts outcome after three years.
PG  - 62-69
LID - S0920-9964(21)00392-3 [pii]
LID - 10.1016/j.schres.2021.09.022 [doi]
AB  - BACKGROUND: Not all patients respond well to early interventions for their 
      psychosis. The present study's goal was to evaluate whether patients' responses 
      in the first six months of treatment in a specialised three-year programme could 
      predict final outcomes. METHODS: 206 early psychosis patients were assessed at 
      baseline, using a large set of sociodemographic and clinical variables, and then 
      monitored for 36 months. Among those variables, changes in their Global 
      Assessment of Functioning (GAF) scores during the first six months were used to 
      predict outcomes after three years. RESULTS: Changes in GAF scores during the 
      first six months were the only variables that predicted every symptom of 
      functional outcome. GAF scores were also always the first or second most 
      important predictor for every outcome. This finding held for both high- and 
      low-functioning patients at baseline. CONCLUSIONS: Predicting poor long-term 
      outcomes after only six months should help clinicians to improve treatments.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Golay, Philippe
AU  - Golay P
AD  - Service of General Psychiatry, Treatment and Early Intervention in Psychosis 
      Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, 
      Switzerland; Service of Community Psychiatry, Department of Psychiatry, Lausanne 
      University Hospital and University of Lausanne, Switzerland. Electronic address: 
      Philippe.Golay@chuv.ch.
FAU - Ramain, Julie
AU  - Ramain J
AD  - Service of General Psychiatry, Treatment and Early Intervention in Psychosis 
      Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, 
      Switzerland.
FAU - Jenni, Raoul
AU  - Jenni R
AD  - Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne 
      University Hospital (CHUV), Switzerland.
FAU - Klauser, Paul
AU  - Klauser P
AD  - Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne 
      University Hospital (CHUV), Switzerland; Service of Child and Adolescent 
      Psychiatry, Department of Psychiatry, Lausanne University Hospital (CHUV), 
      Switzerland.
FAU - Mebdouhi, Nadir
AU  - Mebdouhi N
AD  - Service of General Psychiatry, Treatment and Early Intervention in Psychosis 
      Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, 
      Switzerland.
FAU - Conus, Philippe
AU  - Conus P
AD  - Service of General Psychiatry, Treatment and Early Intervention in Psychosis 
      Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, 
      Switzerland.
FAU - Solida, Alessandra
AU  - Solida A
AD  - Service of General Psychiatry, Treatment and Early Intervention in Psychosis 
      Program (TIPP-Lausanne), Lausanne University Hospital and University of Lausanne, 
      Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211001
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Humans
MH  - *Psychotic Disorders/diagnosis/therapy
OTO - NOTNLM
OT  - Early response
OT  - First episode
OT  - Functioning
OT  - Long-term outcome
OT  - Psychosis
OT  - Schizophrenia
EDAT- 2021/10/05 06:00
MHDA- 2022/03/26 06:00
CRDT- 2021/10/04 20:28
PHST- 2021/04/27 00:00 [received]
PHST- 2021/09/16 00:00 [revised]
PHST- 2021/09/26 00:00 [accepted]
PHST- 2021/10/05 06:00 [pubmed]
PHST- 2022/03/26 06:00 [medline]
PHST- 2021/10/04 20:28 [entrez]
AID - S0920-9964(21)00392-3 [pii]
AID - 10.1016/j.schres.2021.09.022 [doi]
PST - ppublish
SO  - Schizophr Res. 2021 Dec;238:62-69. doi: 10.1016/j.schres.2021.09.022. Epub 2021 
      Oct 1.