PMID- 34607374
OWN - NLM
STAT- MEDLINE
DCOM- 20220622
LR  - 20220623
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 130
IP  - 6
DP  - 2022 Jun
TI  - Elevated Serum Levels of Carbohydrate Antigen 72-4 in Diabetic Kidney Disease.
PG  - 400-405
LID - 10.1055/a-1532-4576 [doi]
AB  - The aim of this study was to determine whether carbohydrate antigen 72-4 (CA72-4) 
      is elevated in diabetic kidney disease (DKD), and examine the association between 
      urinary albumin-to-creatinine ratio (UACR) and CA72-4 in patients with type 2 
      diabetes mellitus (T2DM). Non-dialysis patients with T2DM (n=296) and 90 healthy 
      controls were recruited in this study. CA72-4 level was measured by 
      electrochemiluminescence immunoassay. DKD was defined as UACR>/= 30 mg/g in the 
      absence of a urinary infection or other renal diseases. We found that patients 
      with DKD had significantly higher serum CA72-4 levels compared to those with 
      normoalbuminuria and healthy controls. Positive rates of CA72-4 increased 
      gradually and markedly from normoalbuminuria to microalbuminuria and to 
      macroalbuminuria in diabetic patients (7.5, 11.2, and 17.4%, respectively; P for 
      trend< 0.05). CA72-4 also showed a positive correlation with UACR (r=0.288, P< 
      0.01). Logistic regression analysis revealed the association of increased UACR 
      with an increased odds ratio of elevation of CA72-4 levels (P for trend< 0.05) 
      after multivariable adjustment. In conclusion, serum levels of CA72-4 increase 
      abnormally with the increase in urinary albumin excretion, which affects the 
      specificity of diagnosis of malignancies. An appropriate interpretation of CA72-4 
      is essential to prevent unnecessary and even hazardous diagnostic procedures in 
      patients with T2DM.
CI  - Thieme. All rights reserved.
FAU - Shi, Lei
AU  - Shi L
AD  - Department of Clinical Laboratory, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
FAU - Meng, Jiali
AU  - Meng J
AD  - Department of Clinical Laboratory, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
FAU - Zhang, Bin
AU  - Zhang B
AD  - Department of Clinical Laboratory, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
FAU - Chen, Jiandong
AU  - Chen J
AD  - Department of Clinical Laboratory, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
FAU - Chen, Jianzhong
AU  - Chen J
AD  - Department of Clinical Laboratory, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
FAU - Zhang, Jue
AU  - Zhang J
AD  - Department of Clinical Laboratory, Shuguang Hospital Affiliated to Shanghai 
      University of Traditional Chinese Medicine, Shanghai, China.
LA  - eng
GR  - National Natural Science Foundation of China/82074185/
PT  - Journal Article
DEP - 20211004
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Albumins)
RN  - 0 (Antigens, Tumor-Associated, Carbohydrate)
RN  - 0 (CA-72-4 antigen)
SB  - IM
MH  - Albumins
MH  - Albuminuria/urine
MH  - Antigens, Tumor-Associated, Carbohydrate
MH  - *Diabetes Mellitus, Type 2/diagnosis
MH  - *Diabetic Nephropathies
MH  - Humans
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/10/05 06:00
MHDA- 2022/06/23 06:00
CRDT- 2021/10/04 20:34
PHST- 2021/10/05 06:00 [pubmed]
PHST- 2022/06/23 06:00 [medline]
PHST- 2021/10/04 20:34 [entrez]
AID - 10.1055/a-1532-4576 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2022 Jun;130(6):400-405. doi: 10.1055/a-1532-4576. 
      Epub 2021 Oct 4.