PMID- 34607688
OWN - NLM
STAT- MEDLINE
DCOM- 20211021
LR  - 20211021
IS  - 0737-0806 (Print)
IS  - 0737-0806 (Linking)
VI  - 105
DP  - 2021 Oct
TI  - Morphometric, metabolic, and inflammatory markers across a cohort of client-owned 
      horses and ponies on the insulin dysregulation spectrum.
PG  - 103715
LID - S0737-0806(21)00345-2 [pii]
LID - 10.1016/j.jevs.2021.103715 [doi]
AB  - In human metabolic syndrome and type II diabetes, methylglyoxal (MG), D-lactate, 
      and several cytokines have been recognized as biomarkers of important metabolic 
      and inflammatory processes. Equine metabolic syndrome (EMS) shares many 
      similarities with these human counterparts. The objectives of this 
      cross-sectional study were to compare body condition score (BCS), cresty neck 
      score (CNS), resting insulin, MG, D-lactate, L-lactate, tumor necrosis factor-alpha 
      (TNF-alpha), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1) 
      between horses with and without insulin dysregulation, as classified via combined 
      glucose and insulin test (CGIT). 32 client-owned horses were included. History 
      and morphometric data such as BCS and CNS were recorded. Subjects with 
      abnormalities on physical examination or CBC, elevated ACTH or incomplete 
      information were excluded. Baseline serum or plasma concentrations of biomarkers 
      were tested via commercial ELISA or colorimetric assays. Characteristics of 
      insulin dysregulated and insulin sensitive horses were compared by univariate 
      analysis and forward logistic regression. 12 (38%) of the 32 horses were 
      classified as insulin dysregulated. No significant difference between the 2 
      groups was found for age, BCS, baseline glucose, triglycerides, MG, D-lactate, 
      L-lactate, TNF-alpha, IL-6, and MCP-1. Baseline insulin was significantly associated 
      with insulin dysregulation in univariate analysis (P = 0.02), but not in the 
      final model. Horses with CNS >/= 3 had 11.3 times higher odds of having insulin 
      dysregulation (OR 11.3, 95% C.I. 2.04 - 63.08, P = 0.006). In this population, 
      horses with mild-moderate signs of EMS presented similar metabolic and 
      inflammatory profiles to non-insulin dysregulated controls.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Ragno, Valentina M
AU  - Ragno VM
AD  - Department of Large Animal Clinical Sciences, Western College of Veterinary 
      Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Electronic 
      address: valentina.ragno@usask.ca.
FAU - Klein, Colby D
AU  - Klein CD
AD  - Department of Large Animal Clinical Sciences, Western College of Veterinary 
      Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
FAU - Sereda, Nicole S
AU  - Sereda NS
AD  - Department of Large Animal Clinical Sciences, Western College of Veterinary 
      Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
FAU - Uehlinger, Fabienne D
AU  - Uehlinger FD
AD  - Department of Large Animal Clinical Sciences, Western College of Veterinary 
      Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
FAU - Zello, Gordon A
AU  - Zello GA
AD  - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, 
      Saskatchewan Canada.
FAU - Robinson, Katherine A
AU  - Robinson KA
AD  - Department of Large Animal Clinical Sciences, Western College of Veterinary 
      Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
FAU - Montgomery, Julia B
AU  - Montgomery JB
AD  - Department of Large Animal Clinical Sciences, Western College of Veterinary 
      Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
LA  - eng
PT  - Journal Article
DEP - 20210716
PL  - United States
TA  - J Equine Vet Sci
JT  - Journal of equine veterinary science
JID - 8216840
RN  - 0 (Biomarkers)
RN  - 0 (Insulin)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/veterinary
MH  - *Horse Diseases/diagnosis
MH  - Horses
MH  - Insulin
OTO - NOTNLM
OT  - Cresty neck
OT  - D-lactate
OT  - Laminitis
OT  - Metabolic syndrome
OT  - Metaflammation
OT  - Methylglyoxal
EDAT- 2021/10/06 06:00
MHDA- 2023/02/25 06:00
CRDT- 2021/10/05 05:40
PHST- 2021/01/30 00:00 [received]
PHST- 2021/06/09 00:00 [revised]
PHST- 2021/07/12 00:00 [accepted]
PHST- 2021/10/05 05:40 [entrez]
PHST- 2021/10/06 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
AID - S0737-0806(21)00345-2 [pii]
AID - 10.1016/j.jevs.2021.103715 [doi]
PST - ppublish
SO  - J Equine Vet Sci. 2021 Oct;105:103715. doi: 10.1016/j.jevs.2021.103715. Epub 2021 
      Jul 16.