PMID- 34608267
OWN - NLM
STAT- MEDLINE
DCOM- 20220302
LR  - 20230207
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 47
IP  - 3
DP  - 2022 Feb
TI  - Thalamocortical dysrhythmia in patients with schizophrenia spectrum disorder and 
      individuals at clinical high risk for psychosis.
PG  - 673-680
LID - 10.1038/s41386-021-01180-6 [doi]
AB  - Thalamocortical dysrhythmia (TCD) is a model characterized by abnormal 
      resting-state thalamic oscillatory patterns where the alpha rhythm is replaced by 
      cross-frequency coupling of low- and high-frequency rhythms. Although disrupted 
      thalamic function is a suggested important pathophysiological mechanism 
      underlying schizophrenia, knowledge regarding the TCD model in schizophrenia 
      spectrum disorder (SSD) patients and individuals at clinical high risk (CHR) for 
      psychosis is limited. A total of 169 SSD patients, 106 individuals at CHR for 
      psychosis, and 105 healthy controls (HCs) underwent resting-state 
      electroencephalography recordings. We performed mean global field power (MGFP) 
      spectral analysis between 1 and 49 Hz as well as source-level theta phase-gamma 
      amplitude coupling (TGC) analysis and compared resting-state oscillatory patterns 
      across groups. Correlations between altered TGC values and psychotic symptom 
      severity in the patient group were investigated. Spectral MGFP of low- and 
      high-frequencies was larger in the SSD and CHR groups than in the HC group. The 
      TGC of SSD patients was greater than that of HCs in the right frontal, right 
      parietal, and left and right limbic lobes. Greater TGC in the right frontal and 
      limbic lobes was associated with positive symptom severity in SSD patients. 
      However, TGC in the CHR group was comparable to that in the HCs and was smaller 
      than that in the SSD group in widespread cortical regions. The TCD pattern may be 
      apparent after frank psychotic disorder onset in tandem with overt positive 
      symptoms. A psychosis-risk state without overt psychotic symptoms could be 
      characterized by abnormally increased low- and high-frequency activities with 
      relatively preserved TGC.
CI  - (c) 2021. The Author(s), under exclusive licence to American College of 
      Neuropsychopharmacology.
FAU - Kim, Minah
AU  - Kim M
AUID- ORCID: 0000-0001-8668-0817
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Lee, Tak Hyung
AU  - Lee TH
AD  - Healthcare Sensor Laboratory, Device Research Center, Samsung Advanced Institute 
      of Technology, Samsung Electronics Co. Ltd, Suwon, Republic of Korea.
FAU - Park, Hyungyou
AU  - Park H
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
FAU - Moon, Sun-Young
AU  - Moon SY
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Lho, Silvia Kyungjin
AU  - Lho SK
AUID- ORCID: 0000-0001-7164-9358
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AUID- ORCID: 0000-0002-1060-1462
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea. kwonjs@snu.ac.kr.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea. kwonjs@snu.ac.kr.
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea. kwonjs@snu.ac.kr.
AD  - Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. 
      kwonjs@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211004
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
SB  - IM
MH  - Electroencephalography
MH  - Humans
MH  - *Psychotic Disorders
MH  - *Schizophrenia/complications/diagnostic imaging
MH  - Thalamus/diagnostic imaging
PMC - PMC8782906
COIS- The authors declare no competing interests.
EDAT- 2021/10/06 06:00
MHDA- 2022/03/03 06:00
PMCR- 2023/02/01
CRDT- 2021/10/05 06:31
PHST- 2021/06/03 00:00 [received]
PHST- 2021/09/07 00:00 [accepted]
PHST- 2021/08/18 00:00 [revised]
PHST- 2021/10/06 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/10/05 06:31 [entrez]
PHST- 2023/02/01 00:00 [pmc-release]
AID - 10.1038/s41386-021-01180-6 [pii]
AID - 1180 [pii]
AID - 10.1038/s41386-021-01180-6 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2022 Feb;47(3):673-680. doi: 10.1038/s41386-021-01180-6. 
      Epub 2021 Oct 4.