PMID- 34609516
OWN - NLM
STAT- MEDLINE
DCOM- 20220323
LR  - 20221007
IS  - 1096-0929 (Electronic)
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 184
IP  - 2
DP  - 2021 Nov 24
TI  - Gestational Exposure to Ultrafine Particles Reveals Sex- and Dose-Specific 
      Changes in Offspring Birth Outcomes, Placental Morphology, and Gene Networks.
PG  - 204-213
LID - 10.1093/toxsci/kfab118 [doi]
AB  - Particulate matter (PM) causes adverse developmental outcomes following prenatal 
      exposure, but the underlying biological mechanisms remain uncertain. Here we 
      elucidate the effects of diesel exhaust ultrafine particle (UFP) exposure during 
      pregnancy on placental and fetal development. Time-mated C57Bl/6n mice were 
      gestationally exposed to UFPs at a low dose (LD, 100 microg/m3) or high dose (HD, 
      500 microg/m3) for 6 h daily. Phenotypic effects on fetuses and placental morphology 
      at gestational day (GD) of 18.5 were evaluated, and RNA sequencing was 
      characterized for transcriptomic changes in placental tissue from male and female 
      offspring. A significant decrease in average placental weights and crown to rump 
      lengths was observed in female offspring in the LD exposure group. Gestational 
      UFP exposure altered placental morphology in a dose- and sex-specific manner. 
      Average female decidua areas were significantly greater in the LD and HD groups. 
      Maternal lacunae mean areas were increased in the female LD group, whereas fetal 
      blood vessel mean areas were significantly greater in the male LD and HD groups. 
      RNA sequencing indicated several disturbed cellular functions related to lipid 
      metabolism, which were most pronounced in the LD group and especially in female 
      placental tissue. Our findings demonstrate the vulnerability of offspring exposed 
      to UFPs during pregnancy, highlighting sex-specific effects and emphasizing the 
      importance of mitigating PM exposure to prevent adverse health outcomes.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      Society of Toxicology. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Behlen, Jonathan C
AU  - Behlen JC
AD  - Department of Environmental and Occupational Health.
FAU - Lau, Carmen H
AU  - Lau CH
AD  - Department of Veterinary Pathobiology.
FAU - Li, Yixin
AU  - Li Y
AD  - Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.
FAU - Dhagat, Prit
AU  - Dhagat P
AD  - Alabama School of Osteopathic Medicine, Dothan, Alabama 36303, USA.
FAU - Stanley, Jone A
AU  - Stanley JA
AD  - Covance Laboratories, Inc., Greenfield, Indiana 46140, USA.
FAU - Rodrigues Hoffman, Aline
AU  - Rodrigues Hoffman A
AD  - Department of Veterinary Pathobiology.
FAU - Golding, Michael C
AU  - Golding MC
AD  - Department of Veterinary Physiology and Pharmacology.
FAU - Zhang, Renyi
AU  - Zhang R
AD  - Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.
AD  - Department of Atmospheric Sciences, Texas A&M University, College Station, Texas 
      77843, USA.
FAU - Johnson, Natalie M
AU  - Johnson NM
AUID- ORCID: 0000-0001-8584-9713
AD  - Department of Environmental and Occupational Health.
LA  - eng
GR  - P30 ES029067/ES/NIEHS NIH HHS/United States
GR  - R01 ES028866/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Particulate Matter)
RN  - 0 (Vehicle Emissions)
SB  - IM
MH  - Animals
MH  - Female
MH  - Gene Regulatory Networks
MH  - Male
MH  - Mice
MH  - *Particulate Matter/toxicity
MH  - Placenta
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/chemically induced
MH  - Vehicle Emissions/toxicity
PMC - PMC8633888
OTO - NOTNLM
OT  - air pollution
OT  - developmental and reproductive toxicology
OT  - gestational exposure
OT  - placenta development
OT  - ultrafine particulate matter
EDAT- 2021/10/06 06:00
MHDA- 2022/03/24 06:00
PMCR- 2022/10/05
CRDT- 2021/10/05 12:24
PHST- 2021/10/06 06:00 [pubmed]
PHST- 2022/03/24 06:00 [medline]
PHST- 2021/10/05 12:24 [entrez]
PHST- 2022/10/05 00:00 [pmc-release]
AID - 6381594 [pii]
AID - kfab118 [pii]
AID - 10.1093/toxsci/kfab118 [doi]
PST - ppublish
SO  - Toxicol Sci. 2021 Nov 24;184(2):204-213. doi: 10.1093/toxsci/kfab118.