PMID- 34610479
OWN - NLM
STAT- MEDLINE
DCOM- 20220128
LR  - 20220128
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 72
DP  - 2021 Dec
TI  - Interactions between glial cells and the blood-brain barrier and their role in 
      Alzheimer's disease.
PG  - 101483
LID - S1568-1637(21)00230-0 [pii]
LID - 10.1016/j.arr.2021.101483 [doi]
AB  - Alzheimer's disease (AD), which is an irreversible neurodegenerative disorder 
      characterized by senile plaques and neurofibrillary tangles, is the most common 
      form of dementia worldwide. However, currently, there are no satisfying curative 
      therapies for AD. The blood-brain barrier (BBB) acts as a selective physical 
      barrier and plays protective roles in maintaining brain homeostasis. BBB 
      dysfunction as an upstream or downstream event promotes the onset and progression 
      of AD. Moreover, the pathogenesis of AD caused by BBB injury hasn't been well 
      elucidated. Glial cells, BBB compartments and neurons form a minimal functional 
      unit called the neurovascular unit (NVU). Emerging evidence suggests that glial 
      cells are regulators in maintaining the BBB integrity and neuronal function. 
      Illustrating the regulatory mechanism of glial cells in the BBB assists us in 
      drawing a glial-vascular coupling diagram of AD, which may offer new insight into 
      the pathogenesis of AD and early intervention strategies for AD. This review aims 
      to summarize our current knowledge of glial-BBB interactions and their 
      pathological implications in AD and to provide new therapeutic potentials for 
      future investigations.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Zhao, Ming
AU  - Zhao M
AD  - Institute of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing 100091, China; Beijing University of Chinese Medicine, Beijing 
      100029, China. Electronic address: 1356518148@qq.com.
FAU - Jiang, Xue-Fan
AU  - Jiang XF
AD  - Institute of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing 100091, China; Beijing University of Chinese Medicine, Beijing 
      100029, China. Electronic address: 20200931830@bucm.edu.cn.
FAU - Zhang, Hui-Qin
AU  - Zhang HQ
AD  - Institute of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing 100091, China. Electronic address: xyhpzhq1218@126.com.
FAU - Sun, Jia-Hui
AU  - Sun JH
AD  - Institute of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing 100091, China; Beijing University of Chinese Medicine, Beijing 
      100029, China. Electronic address: sunjiahui16@126.com.
FAU - Pei, Hui
AU  - Pei H
AD  - Institute of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing 100091, China. Electronic address: phxydoctor@126.com.
FAU - Ma, Li-Na
AU  - Ma LN
AD  - Institute of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing 100091, China. Electronic address: malina19860814@126.com.
FAU - Cao, Yu
AU  - Cao Y
AD  - Institute of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing 100091, China. Electronic address: yu.cao-xiyuan@outlook.com.
FAU - Li, Hao
AU  - Li H
AD  - Institute of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing 100091, China. Electronic address: 65090075@sdutcm.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211002
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - *Alzheimer Disease
MH  - *Blood-Brain Barrier
MH  - Brain
MH  - Humans
MH  - Neuroglia
MH  - Neurons
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Astrocytes
OT  - Blood-brain barrier
OT  - Microglia
OT  - Oligodendrocytes
EDAT- 2021/10/06 06:00
MHDA- 2022/01/29 06:00
CRDT- 2021/10/05 20:12
PHST- 2021/05/04 00:00 [received]
PHST- 2021/09/14 00:00 [revised]
PHST- 2021/09/30 00:00 [accepted]
PHST- 2021/10/06 06:00 [pubmed]
PHST- 2022/01/29 06:00 [medline]
PHST- 2021/10/05 20:12 [entrez]
AID - S1568-1637(21)00230-0 [pii]
AID - 10.1016/j.arr.2021.101483 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2021 Dec;72:101483. doi: 10.1016/j.arr.2021.101483. Epub 2021 Oct 
      2.