PMID- 34612964
OWN - NLM
STAT- MEDLINE
DCOM- 20220118
LR  - 20220118
IS  - 1539-4522 (Electronic)
IS  - 1559-128X (Linking)
VI  - 60
IP  - 27
DP  - 2021 Sep 20
TI  - Mid-infrared multispectral confocal microscope using off-axis parabolic mirrors 
      to study epiretinal membranes.
PG  - 8616-8623
LID - 10.1364/AO.436257 [doi]
AB  - Mid-infrared (mid-IR) multispectral microscopy, especially operating at the 
      wavelength of 5-11 microm, is an effective tool for detecting, identifying, and 
      quantifying the structure and composition of biological tissues. Compared with 
      that based on the optical lens, the mid-infrared microscope composed of off-axis 
      parabolic (OAP) mirrors is low cost, simple, and suitable for longer range of 
      wavelength without chromatic aberrations, while keeping the optical transmission 
      efficiency. Here we report a compact and versatile mid-infrared multispectral 
      confocal microscope based on off-axis parabolic mirrors. We also perform 
      numerical calculations based on the vectorial diffraction theory on OAP mirrors 
      and analyze the typical aberrations and misalignment of the OAP-based optical 
      system. Finally, we perform multispectral imaging of the epiretinal membrane of 
      the human eyes with the spectrum selected according to its resonance absorption 
      peak. The system is designed to perform multispectral or even hyperspectral 
      imaging to identify and predict potential disease.
FAU - Zhu, Jiaying
AU  - Zhu J
FAU - Wang, Ruixing
AU  - Wang R
FAU - Liu, Qiao
AU  - Liu Q
FAU - Luo, Zhifu
AU  - Luo Z
FAU - Tian, Bei
AU  - Tian B
FAU - Zhu, Li-Guo
AU  - Zhu LG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Appl Opt
JT  - Applied optics
JID - 0247660
SB  - IM
MH  - Epiretinal Membrane/*diagnostic imaging
MH  - Equipment Design
MH  - Humans
MH  - Lasers
MH  - Microscopy, Confocal/*instrumentation/methods
MH  - Optical Devices
MH  - Signal-To-Noise Ratio
MH  - Spectrophotometry, Infrared
EDAT- 2021/10/07 06:00
MHDA- 2022/01/19 06:00
CRDT- 2021/10/06 12:24
PHST- 2021/10/06 12:24 [entrez]
PHST- 2021/10/07 06:00 [pubmed]
PHST- 2022/01/19 06:00 [medline]
AID - 459220 [pii]
AID - 10.1364/AO.436257 [doi]
PST - ppublish
SO  - Appl Opt. 2021 Sep 20;60(27):8616-8623. doi: 10.1364/AO.436257.