PMID- 34613412
OWN - NLM
STAT- MEDLINE
DCOM- 20220411
LR  - 20220614
IS  - 1753-4887 (Electronic)
IS  - 0029-6643 (Linking)
VI  - 80
IP  - 5
DP  - 2022 Apr 8
TI  - Examining the effects of calorie restriction on testosterone concentrations in 
      men: a systematic review and meta-analysis.
PG  - 1222-1236
LID - 10.1093/nutrit/nuab072 [doi]
AB  - CONTEXT: Testosterone concentrations decline with age, and lower testosterone 
      concentrations are associated with several morbidities, including sexual 
      dysfunction, obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome. 
      OBJECTIVE: Because dietary habits play a critical role in weight regulation and 
      T2DM management, the aim of this systematic review and meta-analysis was to 
      summarize and critically evaluate the evidence from randomized controlled trials 
      to determine the effects of calorie restriction (CR) on testosterone 
      concentrations in men. DATA SOURCES: A literature search was conducted across 4 
      databases, from their inception until March 2020. DATA EXTRACTION: The screening 
      and data extraction were completed by 2 authors independently, and in a blinded 
      manner, according to a priori inclusion and exclusion criteria. DATA ANALYSIS: Of 
      the 4198 studies identified from the initial search, 7 randomized controlled 
      trials were included for data extraction. Significant increases in total 
      testosterone concentrations were reported in 3 of 4 studies in which CR was 
      examined with overweight or obese men, compared with the control groups. 
      Significant decreases in total testosterone concentrations were reported in 2 of 
      3 studies in which the effects of CR were examined with normal-weight, healthy 
      men, compared with the control groups. In all 4 studies that examined the effect 
      of CR on sex hormone-binding globulin concentrations, the intervention 
      significantly increased sex hormone-binding globulin concentrations compared with 
      that of the control groups irrespective of body composition. CONCLUSION: This 
      systematic review and meta-analysis provide some evidence that CR affects 
      testosterone concentrations in men and this effect depends on their body mass 
      index. PROSPERO registration no. CRD42020173102.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      International Life Sciences Institute. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Smith, Stephen J
AU  - Smith SJ
AUID- ORCID: 0000-0002-3875-4815
AD  - Clinical Research Australia, Perth, Western Australia, Australia.
AD  - College of Science, Health, Engineering and Education, Murdoch University, Perth, 
      Western Australia, Australia.
FAU - Teo, Shaun Y M
AU  - Teo SYM
AD  - College of Science, Health, Engineering and Education, Murdoch University, Perth, 
      Western Australia, Australia.
FAU - Lopresti, Adrian L
AU  - Lopresti AL
AD  - Clinical Research Australia, Perth, Western Australia, Australia.
AD  - College of Science, Health, Engineering and Education, Murdoch University, Perth, 
      Western Australia, Australia.
FAU - Heritage, Brody
AU  - Heritage B
AD  - College of Science, Health, Engineering and Education, Murdoch University, Perth, 
      Western Australia, Australia.
FAU - Fairchild, Timothy J
AU  - Fairchild TJ
AD  - College of Science, Health, Engineering and Education, Murdoch University, Perth, 
      Western Australia, Australia.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - United States
TA  - Nutr Rev
JT  - Nutrition reviews
JID - 0376405
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Caloric Restriction
MH  - *Diabetes Mellitus, Type 2/epidemiology/prevention & control
MH  - Humans
MH  - Male
MH  - Obesity
MH  - Overweight
MH  - *Sex Hormone-Binding Globulin/analysis/metabolism
MH  - Testosterone
OTO - NOTNLM
OT  - SHBG
OT  - calorie restriction
OT  - male
OT  - sex hormone-binding globulin
OT  - testosterone
EDAT- 2021/10/07 06:00
MHDA- 2022/04/12 06:00
CRDT- 2021/10/06 12:30
PHST- 2021/10/07 06:00 [pubmed]
PHST- 2022/04/12 06:00 [medline]
PHST- 2021/10/06 12:30 [entrez]
AID - 6382256 [pii]
AID - 10.1093/nutrit/nuab072 [doi]
PST - ppublish
SO  - Nutr Rev. 2022 Apr 8;80(5):1222-1236. doi: 10.1093/nutrit/nuab072.