PMID- 34615497
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 21
IP  - 1
DP  - 2021 Oct 6
TI  - Altered functional connectivity in adolescent anorexia nervosa is related to age 
      and cortical thickness.
PG  - 490
LID - 10.1186/s12888-021-03497-4 [doi]
LID - 490
AB  - INTRODUCTION: Functional networks develop throughout adolescence when anorexia 
      nervosa (AN) normally debuts. In AN, cerebral structural alterations are found in 
      most brain regions and may be related to the observed functional brain changes. 
      Few studies have investigated the functional networks of the brain in adolescent 
      AN patients.. The aim of this explorative study was to investigate multiple 
      functional networks in adolescent AN patients compared to healthy age-matched 
      controls (HC) and the relationship with age, eating disorder symptoms and 
      structural alterations. METHODS: Included were 29 female inpatients with 
      restrictive AN, and 27 HC. All participants were between the ages of 12 to 
      18 years. Independent component analysis (ICA) identified 21 functional networks 
      that were analyzed with multivariate and univariate analyses of components and 
      group affiliation (AN vs HC). Age, age x group interaction and AN symptoms were 
      included as covariates. Follow-up correlational analyses of selected components 
      and structural measures (cortical thickness and subcortical volume) were carried 
      out. RESULTS: Decreased functional connectivity (FC) in AN patients was found in 
      one cortical network, involving mainly the precuneus, and identified as a default 
      mode network (DMN). Cortical thickness in the precuneus was significantly 
      correlated with functional connectivity in this network. Significant group 
      differences were also found in two subcortical networks involving mainly the 
      hippocampus and the amygdala respectively, and a significant interaction effect 
      of age and group was found in both these networks. There were no significant 
      associations between FC and the clinical measures used in the study. CONCLUSION: 
      The findings from the present study may imply that functional alterations are 
      related to structural alterations in selected regions and that the restricted 
      food intake in AN patients disrupt normal age-related development of functional 
      networks involving the amygdala and hippocampus.
CI  - (c) 2021. The Author(s).
FAU - Myrvang, Anna D
AU  - Myrvang AD
AD  - Department of Psychology, Faculty of Health Sciences, UiT The Artic University of 
      Norway, Huginbakken 32, N-9037, Tromso, Norway. anna.d.myrvang@uit.no.
FAU - Vangberg, Torgil R
AU  - Vangberg TR
AD  - Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic 
      University of Norway, Tromso, Norway.
AD  - PET Center, University Hospital of North Norway, Tromso, Norway.
FAU - Linnman, Clas
AU  - Linnman C
AD  - Spaulding Rehabilitation Hospital, Boston, USA.
FAU - Stedal, Kristin
AU  - Stedal K
AD  - Regional Department for Eating Disorders, Division of Mental Health and 
      Addiction, Oslo University Hospital, Oslo, Norway.
FAU - Ro, Oyvind
AU  - Ro O
AD  - Regional Department for Eating Disorders, Division of Mental Health and 
      Addiction, Oslo University Hospital, Oslo, Norway.
AD  - Institute of clinical Medicine, Medical Faculty, University of Oslo, Oslo, 
      Norway.
FAU - Endestad, Tor
AU  - Endestad T
AD  - Department of psychology, Faculty of Social Sciences, University of Oslo, Oslo, 
      Norway.
AD  - Helgelandssykehuset, Mosjoen, Norway.
FAU - Rosenvinge, Jan H
AU  - Rosenvinge JH
AD  - Department of Psychology, Faculty of Health Sciences, UiT The Artic University of 
      Norway, Huginbakken 32, N-9037, Tromso, Norway.
FAU - Aslaksen, Per M
AU  - Aslaksen PM
AD  - Department of Psychology, Faculty of Health Sciences, UiT The Artic University of 
      Norway, Huginbakken 32, N-9037, Tromso, Norway.
AD  - Regional Center for Eating Disorders, University Hospital of North Norway, 
      Tromso, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211006
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
SB  - IM
MH  - Adolescent
MH  - *Anorexia Nervosa/diagnostic imaging
MH  - Brain
MH  - Brain Mapping
MH  - Child
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Neural Pathways/diagnostic imaging
PMC - PMC8496064
OTO - NOTNLM
OT  - Adolescent
OT  - Anorexia nervosa
OT  - Eating disorders
OT  - RS-fMRI
COIS- The authors have no conflict to declare.
EDAT- 2021/10/08 06:00
MHDA- 2021/10/26 06:00
PMCR- 2021/10/06
CRDT- 2021/10/07 05:35
PHST- 2021/04/12 00:00 [received]
PHST- 2021/09/22 00:00 [accepted]
PHST- 2021/10/07 05:35 [entrez]
PHST- 2021/10/08 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/10/06 00:00 [pmc-release]
AID - 10.1186/s12888-021-03497-4 [pii]
AID - 3497 [pii]
AID - 10.1186/s12888-021-03497-4 [doi]
PST - epublish
SO  - BMC Psychiatry. 2021 Oct 6;21(1):490. doi: 10.1186/s12888-021-03497-4.