PMID- 34615830
OWN - NLM
STAT- MEDLINE
DCOM- 20220118
LR  - 20240226
IS  - 1347-3352 (Electronic)
IS  - 1345-8957 (Linking)
VI  - 70
IP  - 10
DP  - 2021
TI  - Cardio-protective and Anti-atherosclerosis Effect of Crocetin on Vitamin D3 and 
      HFD-induced Atherosclerosis in Rats.
PG  - 1447-1459
LID - 10.5650/jos.ess21168 [doi]
AB  - Cardiovascular disease (CVD) is a chronic disease and causes the highest rate of 
      death globally. CVD-related deaths account for 80% of all deaths in low and 
      middle-income countries, such as China. Crocetin (CT), a carotenoid 
      phytoconstituent already confirm their anti-inflammatory and antioxidant effects 
      in various diseases animal models. In the study, we make effort to access the 
      cardio-protective effect of Crocetin against vitamin D3 and high fat induced 
      atherosclerosis in rats and scrutinize the underlying mechanism. Sprague Dawley 
      (SD) rats were used in this study and rats were divided into different groups and 
      high fat diet and vitamin D was used for induction the atherosclerosis. The rats 
      were received oral administration of crocetin (5, 10 and 15 mg/kg) and 
      simvastatin (0.5 mg/kg) until 30 days. At the end of the experimental period, 
      lipid, cardiac markers, anti-inflammatory, antioxidant, pro-inflammatory 
      cytokines and atherogenic index were estimated. The mRNA expression of 
      Intercellular adhesion molecule-1 (ICAM-1), Monocyte Chemoattractant Protein-1 
      (MCP-1) and vascular cell adhesion molecule 1 (VCAM-1) in aortic tissue of the 
      atherosclerotic rats. Crocetin significantly reduced the aortic membrane 
      thickness and platelet aggregation rates. Crocetin also dose-dependently reduced 
      total cholesterol (TC), very low-density lipoprotein (VLDL), triacylglycerol 
      (TG), low-density lipoprotein (LDL) and augmented the level of high-density 
      lipoprotein (HDL) level. Additionally, Crocetin significantly (p < 0.001) 
      abridged the level of malonaldehyde (MDA) and augmented the level of superoxide 
      dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione 
      peroxidase (GPx). Furthermore, Crocetin significantly (p < 0.001) 
      dose-dependently reduced the levels of pro-inflammatory cytokines and 
      inflammatory mediators. Crocetin attenuated mRNA expression of VCAM-1, ICAM-1 and 
      MCP-1. Crocetin had anti-atherosclerosis and cardio-protective effects on vitamin 
      D3 and high fat induced atherosclerosis in rats through anti-inflammatory and 
      antioxidant mechanisms.
FAU - Yu, Laizeng
AU  - Yu L
AUID- ORCID: 0000-0002-6501-3625
AD  - Internal Medicine of Traditional Chinese Medicine, Shandong Xinzhonglu Hospital 
      of Traditional Chinese Medicine.
FAU - Gao, Ruihua
AU  - Gao R
AD  - Nursing College, Nanchang Medical College.
FAU - Song, Xuewen
AU  - Song X
AD  - Internal Medicine of Traditional Chinese Medicine, Shandong Xinzhonglu Hospital 
      of Traditional Chinese Medicine.
FAU - Li, Xuechao
AU  - Li X
AD  - Department of Traditional Chinese Medicine, Fenghuangling Street Hospital.
FAU - Zhu, Jiacheng
AU  - Zhu J
AD  - Internal Medicine of Traditional Chinese Medicine, Shandong Xinzhonglu Hospital 
      of Traditional Chinese Medicine.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Oleo Sci
JT  - Journal of oleo science
JID - 101175339
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 0 (trans-sodium crocetinate)
RN  - 11103-57-4 (Vitamin A)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - 36-88-4 (Carotenoids)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - *Anti-Inflammatory Agents
MH  - *Antioxidants/metabolism
MH  - Aorta/metabolism/pathology
MH  - Atherosclerosis/drug therapy/*etiology/metabolism/*prevention & control
MH  - Carotenoids/*administration & dosage/*pharmacology
MH  - Chemokine CCL2/metabolism
MH  - Cholecalciferol/*adverse effects
MH  - Cytokines/metabolism
MH  - Diet, High-Fat/*adverse effects
MH  - Disease Models, Animal
MH  - Inflammation Mediators/metabolism
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Lipid Metabolism/drug effects
MH  - *Phytotherapy
MH  - Rats, Sprague-Dawley
MH  - Vascular Cell Adhesion Molecule-1/metabolism
MH  - Vitamin A/administration & dosage/*analogs & derivatives/pharmacology
MH  - Rats
OTO - NOTNLM
OT  - Vitamin D3
OT  - anti-atherosclerosis
OT  - cardio-protective
OT  - crocetin
OT  - high fat diet
EDAT- 2021/10/08 06:00
MHDA- 2022/01/19 06:00
CRDT- 2021/10/07 06:01
PHST- 2021/10/07 06:01 [entrez]
PHST- 2021/10/08 06:00 [pubmed]
PHST- 2022/01/19 06:00 [medline]
AID - 10.5650/jos.ess21168 [doi]
PST - ppublish
SO  - J Oleo Sci. 2021;70(10):1447-1459. doi: 10.5650/jos.ess21168.