PMID- 34615944
OWN - NLM
STAT- MEDLINE
DCOM- 20211230
LR  - 20211230
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Oct 6
TI  - Heterozygosity of the major histocompatibility complex predicts later 
      self-reported pubertal maturation in men.
PG  - 19862
LID - 10.1038/s41598-021-99334-5 [doi]
LID - 19862
AB  - Individual variation in the age of pubertal onset is linked to physical and 
      mental health, yet the factors underlying this variation are poorly understood. 
      Life history theory predicts that individuals at higher risk of mortality due to 
      extrinsic causes such as infectious disease should sexually mature and reproduce 
      earlier, whereas those at lower risk can delay puberty and continue to invest 
      resources in somatic growth. We examined relationships between a genetic 
      predictor of infectious disease resistance, heterozygosity of the major 
      histocompatibility complex (MHC), referred to as the human leukocyte antigen 
      (HLA) gene in humans, and self-reported pubertal timing. In a combined sample of 
      men from Canada (n = 137) and the United States (n = 43), MHC heterozygosity 
      predicted later self-reported pubertal development. These findings suggest a 
      genetic trade-off between immunocompetence and sexual maturation in human males.
CI  - (c) 2021. The Author(s).
FAU - Arnocky, Steven
AU  - Arnocky S
AD  - Nipissing University, North Bay, Canada. stevena@nipissingu.ca.
FAU - Hodges-Simeon, Carolyn
AU  - Hodges-Simeon C
AD  - Boston University, Boston, USA.
FAU - Davis, Adam C
AU  - Davis AC
AD  - University of Ottawa, Ottawa, Canada.
FAU - Desmarais, Riley
AU  - Desmarais R
AD  - Nipissing University, North Bay, Canada.
FAU - Greenshields, Anna
AU  - Greenshields A
AD  - Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, Canada.
FAU - Liwski, Robert
AU  - Liwski R
AD  - Queen Elizabeth II Health Sciences Centre, Dalhousie University, Halifax, Canada.
FAU - Quillen, Ellen E
AU  - Quillen EE
AD  - Wake Forest School of Medicine, Winston-Salem, USA.
FAU - Cardenas, Rodrigo
AU  - Cardenas R
AD  - Pennsylvania State University, State College, USA.
FAU - Breedlove, S Marc
AU  - Breedlove SM
AD  - Michigan State University, East Lansing, USA.
FAU - Puts, David
AU  - Puts D
AD  - Pennsylvania State University, State College, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211006
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Alleles
MH  - Disease Resistance/genetics
MH  - Disease Susceptibility/immunology
MH  - Genetic Predisposition to Disease
MH  - *Heterozygote
MH  - Humans
MH  - Major Histocompatibility Complex/*genetics/immunology
MH  - Male
MH  - Puberty/*genetics/immunology
MH  - Self Report
MH  - Young Adult
PMC - PMC8494901
COIS- The authors declare no competing interests.
EDAT- 2021/10/08 06:00
MHDA- 2021/12/31 06:00
PMCR- 2021/10/06
CRDT- 2021/10/07 06:32
PHST- 2021/04/18 00:00 [received]
PHST- 2021/09/23 00:00 [accepted]
PHST- 2021/10/07 06:32 [entrez]
PHST- 2021/10/08 06:00 [pubmed]
PHST- 2021/12/31 06:00 [medline]
PHST- 2021/10/06 00:00 [pmc-release]
AID - 10.1038/s41598-021-99334-5 [pii]
AID - 99334 [pii]
AID - 10.1038/s41598-021-99334-5 [doi]
PST - epublish
SO  - Sci Rep. 2021 Oct 6;11(1):19862. doi: 10.1038/s41598-021-99334-5.