PMID- 34616253 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211008 IS - 1662-0631 (Print) IS - 1662-0631 (Electronic) IS - 1662-0631 (Linking) VI - 15 IP - 2 DP - 2021 May-Aug TI - Proton Pump Inhibitor-Associated Large Hyperplastic Polyp in Non-Helicobacter pylori-Infected Stomach. PG - 539-544 LID - 10.1159/000514530 [doi] AB - A proton pump inhibitor (PPI)-associated hyperplastic polyp (HP) in the non-Helicobacter pylori-infected stomach is rare, and its endoscopic features remain poorly described. A 42-year-old man with tarry stool was referred to our hospital for examination and treatment. He had taken PPI for 14 years and was confirmed to be H. pylori-negative. Transnasal endoscopy revealed bleeding from a 20-mm, reddish pedunculated polyp with a nodular surface, located in the greater curvature of the upper gastric body. Endoscopic mucosal resection was performed, and the lesion was diagnosed as an HP. To our knowledge, this report represents a valuable addition to the HP literature describing a rare case of PPI-associated large HP in the non-H. pylori-infected stomach. CI - Copyright (c) 2021 by S. Karger AG, Basel. FAU - Kubo, Kimitoshi AU - Kubo K AD - Departments of Gastroenterology and Pathology, Hakodate, Japan. FAU - Kimura, Noriko AU - Kimura N AD - National Hospital Organization Hakodate National Hospital, Hakodate, Japan. FAU - Maiya, Norishige AU - Maiya N AD - Departments of Gastroenterology and Pathology, Hakodate, Japan. FAU - Matsuda, Soichiro AU - Matsuda S AD - Departments of Gastroenterology and Pathology, Hakodate, Japan. FAU - Tsuda, Momoko AU - Tsuda M AD - Departments of Gastroenterology and Pathology, Hakodate, Japan. FAU - Mizushima, Takeshi AU - Mizushima T AD - Departments of Gastroenterology and Pathology, Hakodate, Japan. FAU - Kato, Mototsugu AU - Kato M AD - Departments of Gastroenterology and Pathology, Hakodate, Japan. LA - eng PT - Case Reports DEP - 20210621 PL - Switzerland TA - Case Rep Gastroenterol JT - Case reports in gastroenterology JID - 101474819 PMC - PMC8454250 OTO - NOTNLM OT - Helicobacter pylori-negative status OT - Hyperplastic polyp OT - Linked color imaging OT - Proton pump inhibitor COIS- The authors have no conflicts of interest to disclose in association with this study. EDAT- 2021/10/08 06:00 MHDA- 2021/10/08 06:01 PMCR- 2021/06/21 CRDT- 2021/10/07 06:54 PHST- 2021/01/06 00:00 [received] PHST- 2021/01/13 00:00 [accepted] PHST- 2021/10/07 06:54 [entrez] PHST- 2021/10/08 06:00 [pubmed] PHST- 2021/10/08 06:01 [medline] PHST- 2021/06/21 00:00 [pmc-release] AID - crg-0015-0539 [pii] AID - 10.1159/000514530 [doi] PST - epublish SO - Case Rep Gastroenterol. 2021 Jun 21;15(2):539-544. doi: 10.1159/000514530. eCollection 2021 May-Aug.