PMID- 34617287
OWN - NLM
STAT- MEDLINE
DCOM- 20220421
LR  - 20220421
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 77
IP  - 4
DP  - 2022 Apr
TI  - Advances and highlights in T and B cell responses to drug antigens.
PG  - 1129-1138
LID - 10.1111/all.15126 [doi]
AB  - The immunological mechanisms involved in drug hypersensitivity reactions (DHRs) 
      are complex, and despite important advances, multiple aspects remain poorly 
      understood. These not fully known aspects are mainly related to the factors that 
      drive towards either a tolerant or a hypersensitivity response and specifically 
      regarding the role of B and T cells. In this review, we focus on recent findings 
      on this knowledge area within the last 2 years. We highlight new evidences of 
      covalent and non-covalent interactions of drug antigen with proteins, as well as 
      the very first characterization of naturally processed flucloxacillin-haptenated 
      human leukocyte antigen (HLA) ligands. Moreover, we have analysed new insights 
      into the identification of risk factors associated with the development of DHRs, 
      such as the role of oxidative metabolism of drugs in the activation of the immune 
      system and the discovery of new associations between DHRs and HLA variants. 
      Finally, evidence of IgG-mediated anaphylaxis in humans and the involvement of 
      specific subpopulations of effector cells associated with different clinical 
      entities are also topics explored in this review. All these recent findings are 
      relevant for the underlying pathology mechanisms and advance the field towards a 
      more precise diagnosis, management and treatment approach for DHRs.
CI  - (c) 2021 The Authors. Allergy published by European Academy of Allergy and Clinical 
      Immunology and John Wiley & Sons Ltd.
FAU - Fernandez-Santamaria, Ruben
AU  - Fernandez-Santamaria R
AUID- ORCID: 0000-0002-0255-4280
AD  - Allergy Research Group, Instituto de Investigacion Biomedica de 
      Malaga-IBIMA-ARADyAL, Malaga, Spain.
FAU - Ariza, Adriana
AU  - Ariza A
AUID- ORCID: 0000-0003-1524-9602
AD  - Allergy Research Group, Instituto de Investigacion Biomedica de 
      Malaga-IBIMA-ARADyAL, Malaga, Spain.
FAU - Fernandez, Tahia D
AU  - Fernandez TD
AUID- ORCID: 0000-0003-0625-2156
AD  - Allergy Research Group, Instituto de Investigacion Biomedica de 
      Malaga-IBIMA-ARADyAL, Malaga, Spain.
AD  - Departamento de Biologia Celular, Genetica y Fisiologia, Universidad de Malaga, 
      Malaga, Spain.
FAU - Cespedes, Jose A
AU  - Cespedes JA
AD  - Allergy Research Group, Instituto de Investigacion Biomedica de 
      Malaga-IBIMA-ARADyAL, Malaga, Spain.
FAU - Labella, Marina
AU  - Labella M
AD  - Allergy Research Group, Instituto de Investigacion Biomedica de 
      Malaga-IBIMA-ARADyAL, Malaga, Spain.
AD  - Allergy Unit, Hospital Regional Universitario de Malaga-ARADyAL, Malaga, Spain.
FAU - Mayorga, Cristobalina
AU  - Mayorga C
AUID- ORCID: 0000-0001-8852-8077
AD  - Allergy Research Group, Instituto de Investigacion Biomedica de 
      Malaga-IBIMA-ARADyAL, Malaga, Spain.
AD  - Allergy Unit, Hospital Regional Universitario de Malaga-ARADyAL, Malaga, Spain.
AD  - Andalusian Center for Nanomedicine and Biotechnology-BIONAND, Malaga, Spain.
FAU - Torres, Maria J
AU  - Torres MJ
AUID- ORCID: 0000-0001-5228-471X
AD  - Allergy Research Group, Instituto de Investigacion Biomedica de 
      Malaga-IBIMA-ARADyAL, Malaga, Spain.
AD  - Allergy Unit, Hospital Regional Universitario de Malaga-ARADyAL, Malaga, Spain.
AD  - Andalusian Center for Nanomedicine and Biotechnology-BIONAND, Malaga, Spain.
AD  - Departamento de Medicina, Universidad de Malaga, Malaga, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211015
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (HLA Antigens)
SB  - IM
MH  - B-Lymphocytes
MH  - *Drug Hypersensitivity
MH  - HLA Antigens/genetics
MH  - Humans
MH  - T-Lymphocytes
OTO - NOTNLM
OT  - B cell
OT  - T cell
OT  - basic immunology
OT  - drug allergy
EDAT- 2021/10/08 06:00
MHDA- 2022/04/22 06:00
CRDT- 2021/10/07 07:10
PHST- 2021/03/31 00:00 [revised]
PHST- 2021/07/19 00:00 [received]
PHST- 2021/09/15 00:00 [accepted]
PHST- 2021/10/08 06:00 [pubmed]
PHST- 2022/04/22 06:00 [medline]
PHST- 2021/10/07 07:10 [entrez]
AID - 10.1111/all.15126 [doi]
PST - ppublish
SO  - Allergy. 2022 Apr;77(4):1129-1138. doi: 10.1111/all.15126. Epub 2021 Oct 15.