PMID- 34617855
OWN - NLM
STAT- MEDLINE
DCOM- 20220307
LR  - 20220307
IS  - 1533-0338 (Electronic)
IS  - 1533-0346 (Print)
IS  - 1533-0338 (Linking)
VI  - 20
DP  - 2021 Jan-Dec
TI  - Comparative Evaluation of 4-Dimensional Computed Tomography and 4-Dimensional 
      Magnetic Resonance Imaging to Delineate the Target of Primary Liver Cancer.
PG  - 15330338211045499
LID - 10.1177/15330338211045499 [doi]
LID - 15330338211045499
AB  - Purpose: To evaluate the feasibility of 4-dimensional magnetic resonance imaging 
      (4DMRI) in establishing the target of primary liver cancer in comparison with 
      4-dimensional computed tomography (4DCT). Methods and Materials: A total of 23 
      patients with primary liver cancer who received radiotherapy were selected, and 
      4DCT and T2w-4DMRI simulations were conducted to obtain 4DCT and T2w-4DMRI 
      simulation images. The 4DCT and T2w-4DMRI data were sorted into 10 and 8 
      respiratory phase bins, respectively. The liver and gross tumor volumes (GTVs) 
      were delineated in all images using programmed clinical workflows under tumor 
      delineation guidelines. The internal organs at risk volumes (IRVs) and internal 
      target volumes (ITVs) were the unions of all the phase livers and GTVs, 
      respectively. Then, the artifacts, liver volume, GTV, and motion range in 4DCT 
      and T2w-4DMRI were compared. Results: The mean GTV volume based on 4DMRI was 
      136.42 +/- 231.27 cm(3), which was 25.04 cm(3) (15.5%) less than that of 4DCT 
      (161.46 +/- 280.29 cm(3)). The average volume of ITV determined by 4DMRI was 
      166.12 +/- 270.43 cm(3), which was 22.44 cm(3) (11.9%) less than that determined by 
      4DCT (188.56 +/- 307.57 cm(3)). Liver volume and IRV in 4DMRI increased by 4.0% and 
      6.6%, respectively, compared with 4DCT. The difference in tumor motion by 
      T2w-4DMRI based on the centroid was greater than that of 4DCT in the L/R, A/P, 
      and S/I directions, and the average displacement differences were 2.6, 2.8, and 
      6.9 mm, respectively. The severe artifacts in 4DCT were 47.8% (11/23) greater 
      than in 4DMRI 17.4% (4/23). Conclusions: Compared with 4DCT, T2-weighted and 
      navigator-triggered 4DMRI produces fewer artifacts and larger motion differences 
      in hepatic intrafraction tumors, which is a feasible technique for primary liver 
      cancer treatment planning.
FAU - Chen, Yukai
AU  - Chen Y
AUID- ORCID: 0000-0002-9762-3022
AD  - East China University of Technology, Nanchang, Jiangxi, China.
FAU - Gong, Guanzhong
AU  - Gong G
AD  - Shandong Cancer Hospital and Institute, Shandong First Medical University and 
      Shandong Academy of Medical Sciences, Jinan, Shandong Province, China.
FAU - Wang, Yinxing
AU  - Wang Y
AD  - Shandong Cancer Hospital and Institute, Shandong First Medical University and 
      Shandong Academy of Medical Sciences, Jinan, Shandong Province, China.
FAU - Liu, Chenlu
AU  - Liu C
AD  - School of Nuclear Science and Technology, University of South China, Hengyang, 
      China.
FAU - Su, Ya
AU  - Su Y
AD  - Shandong Cancer Hospital and Institute, Shandong First Medical University and 
      Shandong Academy of Medical Sciences, Jinan, Shandong Province, China.
FAU - Wang, Lizhen
AU  - Wang L
AD  - Shandong Cancer Hospital and Institute, Shandong First Medical University and 
      Shandong Academy of Medical Sciences, Jinan, Shandong Province, China.
FAU - Yang, Bo
AU  - Yang B
AD  - East China University of Technology, Nanchang, Jiangxi, China.
FAU - Yin, Yong
AU  - Yin Y
AD  - Shandong Cancer Hospital and Institute, Shandong First Medical University and 
      Shandong Academy of Medical Sciences, Jinan, Shandong Province, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Technol Cancer Res Treat
JT  - Technology in cancer research & treatment
JID - 101140941
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Four-Dimensional Computed Tomography/*methods
MH  - Humans
MH  - Liver Neoplasms/diagnostic imaging/*pathology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Movement
MH  - Organs at Risk/*radiation effects
MH  - Radiotherapy Planning, Computer-Assisted/*methods
PMC - PMC8504652
OTO - NOTNLM
OT  - 4DCT
OT  - MRI
OT  - liver cancer
OT  - radiotherapy
OT  - respiratory motion simulation
OT  - tumor delineation
COIS- Declaration of Conflicting Interests: The authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2021/10/08 06:00
MHDA- 2022/03/08 06:00
PMCR- 2021/10/07
CRDT- 2021/10/07 12:17
PHST- 2021/10/07 12:17 [entrez]
PHST- 2021/10/08 06:00 [pubmed]
PHST- 2022/03/08 06:00 [medline]
PHST- 2021/10/07 00:00 [pmc-release]
AID - 10.1177_15330338211045499 [pii]
AID - 10.1177/15330338211045499 [doi]
PST - ppublish
SO  - Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211045499. doi: 
      10.1177/15330338211045499.