PMID- 34618070
OWN - NLM
STAT- MEDLINE
DCOM- 20220225
LR  - 20220817
IS  - 1532-2548 (Electronic)
IS  - 0032-0889 (Print)
IS  - 0032-0889 (Linking)
VI  - 187
IP  - 3
DP  - 2021 Nov 3
TI  - Long-term acclimation to cadmium exposure reveals extensive phenotypic plasticity 
      in Chlamydomonas.
PG  - 1653-1678
LID - 10.1093/plphys/kiab375 [doi]
AB  - Increasing industrial and anthropogenic activities are producing and releasing 
      more and more pollutants in the environment. Among them, toxic metals are one of 
      the major threats for human health and natural ecosystems. Because photosynthetic 
      organisms play a critical role in primary productivity and pollution management, 
      investigating their response to metal toxicity is of major interest. Here, the 
      green microalga Chlamydomonas (Chlamydomonas reinhardtii) was subjected to short 
      (3 d) or chronic (6 months) exposure to 50 microM cadmium (Cd), and the recovery from 
      chronic exposure was also examined. An extensive phenotypic characterization and 
      transcriptomic analysis showed that the impact of Cd on biomass production of 
      short-term (ST) exposed cells was almost entirely abolished by long-term (LT) 
      acclimation. The underlying mechanisms were initiated at ST and further amplified 
      after LT exposure resulting in a reversible equilibrium allowing biomass 
      production similar to control condition. This included modification of cell 
      wall-related gene expression and biofilm-like structure formation, dynamics of 
      metal ion uptake and homeostasis, photosynthesis efficiency recovery and Cd 
      acclimation through metal homeostasis adjustment. The contribution of the 
      identified coordination of phosphorus and iron homeostasis (partly) mediated by 
      the main phosphorus homeostasis regulator, Phosphate Starvation Response 1, and a 
      basic Helix-Loop-Helix transcription factor (Cre05.g241636) was further 
      investigated. The study reveals the highly dynamic physiological plasticity 
      enabling algal cell growth in an extreme environment.
CI  - (c) American Society of Plant Biologists 2021. All rights reserved. For 
      permissions, please email: journals.permissions@oup.com.
FAU - Thiriet-Rupert, Stanislas
AU  - Thiriet-Rupert S
AD  - InBioS-PhytoSystems, Functional Genomics and Plant Molecular Imaging, University 
      of Liege, 4000 Liege, Belgium.
FAU - Gain, Gwenaelle
AU  - Gain G
AD  - InBioS-PhytoSystems, Functional Genomics and Plant Molecular Imaging, University 
      of Liege, 4000 Liege, Belgium.
AD  - InBioS-PhytoSystems, Genetics and Physiology of Microalgae, University of Liege, 
      4000 Liege, Belgium.
FAU - Jadoul, Alice
AU  - Jadoul A
AD  - InBioS-PhytoSystems, Functional Genomics and Plant Molecular Imaging, University 
      of Liege, 4000 Liege, Belgium.
FAU - Vigneron, Amandine
AU  - Vigneron A
AD  - InBioS-PhytoSystems, Functional Genomics and Plant Molecular Imaging, University 
      of Liege, 4000 Liege, Belgium.
FAU - Bosman, Bernard
AU  - Bosman B
AUID- ORCID: 0000-0001-7855-954X
AD  - InBioS-PhytoSystems, Laboratory of Plant and Microbial Ecology, University of 
      Liege, 4000 Liege, Belgium.
FAU - Carnol, Monique
AU  - Carnol M
AD  - InBioS-PhytoSystems, Laboratory of Plant and Microbial Ecology, University of 
      Liege, 4000 Liege, Belgium.
FAU - Motte, Patrick
AU  - Motte P
AD  - InBioS-PhytoSystems, Functional Genomics and Plant Molecular Imaging, University 
      of Liege, 4000 Liege, Belgium.
FAU - Cardol, Pierre
AU  - Cardol P
AUID- ORCID: 0000-0001-9799-0546
AD  - InBioS-PhytoSystems, Genetics and Physiology of Microalgae, University of Liege, 
      4000 Liege, Belgium.
FAU - Nouet, Cecile
AU  - Nouet C
AUID- ORCID: 0000-0002-0443-7774
AD  - InBioS-PhytoSystems, Functional Genomics and Plant Molecular Imaging, University 
      of Liege, 4000 Liege, Belgium.
FAU - Hanikenne, Marc
AU  - Hanikenne M
AUID- ORCID: 0000-0002-8964-9601
AD  - InBioS-PhytoSystems, Functional Genomics and Plant Molecular Imaging, University 
      of Liege, 4000 Liege, Belgium.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Plant Physiol
JT  - Plant physiology
JID - 0401224
RN  - 00BH33GNGH (Cadmium)
SB  - IM
MH  - *Acclimatization
MH  - *Adaptation, Physiological
MH  - Biomass
MH  - Cadmium/*metabolism
MH  - Chlamydomonas/*drug effects/physiology
MH  - Time Factors
PMC - PMC8566208
EDAT- 2021/10/08 06:00
MHDA- 2022/02/26 06:00
PMCR- 2022/08/16
CRDT- 2021/10/07 12:26
PHST- 2021/07/17 00:00 [accepted]
PHST- 2021/05/21 00:00 [received]
PHST- 2021/10/08 06:00 [pubmed]
PHST- 2022/02/26 06:00 [medline]
PHST- 2021/10/07 12:26 [entrez]
PHST- 2022/08/16 00:00 [pmc-release]
AID - 6353050 [pii]
AID - kiab375 [pii]
AID - 10.1093/plphys/kiab375 [doi]
PST - ppublish
SO  - Plant Physiol. 2021 Nov 3;187(3):1653-1678. doi: 10.1093/plphys/kiab375.