PMID- 34619181
OWN - NLM
STAT- MEDLINE
DCOM- 20220412
LR  - 20220719
IS  - 1097-6825 (Electronic)
IS  - 0091-6749 (Linking)
VI  - 149
IP  - 4
DP  - 2022 Apr
TI  - Development and validation of the Exercise-Induced Laryngeal Obstruction Dyspnea 
      Index (EILODI).
PG  - 1437-1444
LID - S0091-6749(21)01512-8 [pii]
LID - 10.1016/j.jaci.2021.09.027 [doi]
AB  - BACKGROUND: Exercise-induced laryngeal obstruction (EILO) causes exertional 
      dyspnea and is important for its effect on quality of life, diagnostic confusion 
      with exercise-induced asthma, and health care resource utilization. There is no 
      validated patient-reported outcome measure specific to EILO. OBJECTIVE: We sought 
      to develop, validate, and define a minimal clinically important difference for a 
      patient-reported outcome measure to be used with adolescents and young adults 
      with EILO. METHODS: A multidisciplinary group created a preliminary measure, 
      modified by a 10-member participant focus group, with 20 items scored along a 
      5-point Likert scale. A subsequent cohort of participants recruited from a 
      clinic, aged 12 to 21 years, with confirmed EILO by continuous laryngoscopy 
      during exercise testing (1) completed the measure at 3 points in time over 28 
      days and (2) provided anchoring data in the form of a daily exercise log and 
      categorical self-assessments of clinical improvement. Thirty additional 
      participants without exertional dyspnea served as controls. RESULTS: Two hundred 
      nineteen subjects with mild to severe EILO participated in the exploratory factor 
      analysis, which identified 7 factors within the preliminary outcome measure. 
      After a process of item reduction, a 12-item metric with a total score ranging 
      from 0 to 48 was developed. Mean scores of patients with EILO and healthy 
      controls at baseline were 28.8 +/- 7.4 and 4.5 +/- 7.4, respectively. A minimal 
      clinically important difference of 6 was determined by comparison of index change 
      with changes in categorical self-assessments of improvement. CONCLUSIONS: This is 
      the first patient-reported outcome measure specifically designed for adolescents 
      and young adults with EILO.
CI  - Copyright (c) 2021 American Academy of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Olin, James Tod
AU  - Olin JT
AD  - Department of Pediatrics, National Jewish Health, Denver, Colo; Department of 
      Medicine, National Jewish Health, Denver, Colo. Electronic address: 
      olint@njhealth.org.
FAU - Shaffer, Monica
AU  - Shaffer M
AD  - Department of Rehabilitation Medicine, National Jewish Health, Denver, Colo.
FAU - Nauman, Emily
AU  - Nauman E
AD  - Department of Rehabilitation Medicine, National Jewish Health, Denver, Colo.
FAU - Durso, Catherine S
AU  - Durso CS
AD  - Department of Computer Science, University of Denver, Denver, Colo.
FAU - Fan, Elizabeth M
AU  - Fan EM
AD  - Department of Pediatrics, National Jewish Health, Denver, Colo.
FAU - Staudenmayer, Herman
AU  - Staudenmayer H
AD  - Department of Psychiatry, University of Colorado School of Medicine, Aurora, 
      Colo.
FAU - Christopher, Kent L
AU  - Christopher KL
AD  - Department of Medicine, University of Colorado School of Medicine, Aurora, Colo.
FAU - Gartner-Schmidt, Jackie
AU  - Gartner-Schmidt J
AD  - Department of Otolaryngology, University of Pittsburgh Medical Center, 
      Pittsburgh, Pa.
LA  - eng
PT  - Journal Article
DEP - 20211004
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
SB  - IM
CIN - J Allergy Clin Immunol. 2022 Apr;149(4):1216-1217. PMID: 34953793
MH  - Adolescent
MH  - *Airway Obstruction/diagnosis/etiology
MH  - *Asthma, Exercise-Induced/diagnosis
MH  - Dyspnea/diagnosis/etiology
MH  - Exercise
MH  - Humans
MH  - *Laryngeal Diseases
MH  - Quality of Life
MH  - Young Adult
OTO - NOTNLM
OT  - CLE
OT  - EILO
OT  - EILODI
OT  - Exercise-Induced Laryngeal Obstruction Dyspnea Index
OT  - Exercise-induced laryngeal obstruction
OT  - VCD
OT  - continuous laryngoscopy during exercise
OT  - paradoxical vocal fold motion
OT  - patient-reported outcome measure
OT  - questionnaire
OT  - vocal cord dysfunction
EDAT- 2021/10/08 06:00
MHDA- 2022/04/13 06:00
CRDT- 2021/10/07 20:16
PHST- 2021/03/23 00:00 [received]
PHST- 2021/09/06 00:00 [revised]
PHST- 2021/09/23 00:00 [accepted]
PHST- 2021/10/08 06:00 [pubmed]
PHST- 2022/04/13 06:00 [medline]
PHST- 2021/10/07 20:16 [entrez]
AID - S0091-6749(21)01512-8 [pii]
AID - 10.1016/j.jaci.2021.09.027 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2022 Apr;149(4):1437-1444. doi: 
      10.1016/j.jaci.2021.09.027. Epub 2021 Oct 4.