PMID- 34620308
OWN - NLM
STAT- MEDLINE
DCOM- 20211020
LR  - 20211020
IS  - 2405-4577 (Electronic)
IS  - 2405-4577 (Linking)
VI  - 45
DP  - 2021 Oct
TI  - CT-based assessment of body composition and skeletal muscle in melanoma: A 
      systematic review.
PG  - 127-133
LID - S2405-4577(21)00240-0 [pii]
LID - 10.1016/j.clnesp.2021.06.029 [doi]
AB  - BACKGROUND/OBJECTIVES: Sarcopenia (low skeletal muscle index) and myosteatosis 
      (low skeletal radiodensity) have been associated with poor outcomes in melanoma. 
      This systematic review was performed to summarize and critically evaluate current 
      literature surrounding body composition in melanoma. METHODS: MEDLINE and Embase 
      databases were searched for studies of melanoma patients with computed tomography 
      (CT) based body composition analysis from 2000 to 2020. Outcomes of interest were 
      survival, including overall survival (OS), progression-free survival (PFS), and 
      disease-free survival (DFS), as well as treatment-related adverse events (AEs). 
      RESULTS: Nine studies of 914 patients were included in the final review. The 
      majority of studies were of metastatic melanoma patients treated with 
      immunotherapy. Studies demonstrated a variety of CT analysis techniques and 
      cut-offs to define sarcopenia and myosteatosis. Associations of sarcopenia or 
      myosteatosis with survival (OS, PFS, DFS) or risk of treatment-related AEs were 
      conflicting. Multiple studies had low quality of evidence due to small sample 
      sizes, use of non-validated CT measures, and lack of multivariable analyses. 
      CONCLUSIONS: Due to methodologic heterogeneity and low quality of evidence, 
      impacts of CT-derived body composition parameters on outcomes in melanoma are 
      unclear. Further research should be conducted to elucidate impacts of body 
      composition in melanoma.
CI  - Copyright (c) 2021 European Society for Clinical Nutrition and Metabolism. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Youn, Susie
AU  - Youn S
AD  - Department of Surgery, University of Alberta, Edmonton, AB, Canada; School of 
      Public Health, University of Alberta, Edmonton, AB, Canada.
FAU - Jogiat, Uzair
AU  - Jogiat U
AD  - Department of Surgery, University of Alberta, Edmonton, AB, Canada.
FAU - Baracos, Vickie E
AU  - Baracos VE
AD  - Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
FAU - McCall, Michael
AU  - McCall M
AD  - Department of Surgery, University of Alberta, Edmonton, AB, Canada.
FAU - Eurich, Dean T
AU  - Eurich DT
AD  - School of Public Health, University of Alberta, Edmonton, AB, Canada.
FAU - Sawyer, Michael B
AU  - Sawyer MB
AD  - Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada. Electronic 
      address: michael.sawyer@ahs.ca.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20210709
PL  - England
TA  - Clin Nutr ESPEN
JT  - Clinical nutrition ESPEN
JID - 101654592
SB  - IM
MH  - *Body Composition
MH  - Humans
MH  - *Melanoma
MH  - Muscle, Skeletal
MH  - Prognosis
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Body composition
OT  - Melanoma
OT  - Myosteatosis
OT  - Prognosis
OT  - Sarcopenia
COIS- Declaration of competing interest There are no commercial disclaimers.
EDAT- 2021/10/09 06:00
MHDA- 2021/10/21 06:00
CRDT- 2021/10/08 05:47
PHST- 2021/01/24 00:00 [received]
PHST- 2021/05/28 00:00 [revised]
PHST- 2021/06/29 00:00 [accepted]
PHST- 2021/10/08 05:47 [entrez]
PHST- 2021/10/09 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
AID - S2405-4577(21)00240-0 [pii]
AID - 10.1016/j.clnesp.2021.06.029 [doi]
PST - ppublish
SO  - Clin Nutr ESPEN. 2021 Oct;45:127-133. doi: 10.1016/j.clnesp.2021.06.029. Epub 
      2021 Jul 9.