PMID- 34621771
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211009
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 8
DP  - 2021
TI  - The Effect of Oral Nutritional Formula With Three Different Proteins on Type 2 
      Diabetes Mellitus in vivo.
PG  - 680700
LID - 10.3389/fnut.2021.680700 [doi]
LID - 680700
AB  - Oral nutritional (ON) products are an effective way to treat patients with type 2 
      diabetes mellitus (T2DM) whose gastrointestinal functions are normal. The 
      influence of ON formula prepared with three different proteins on T2DM was 
      studied. The hyperglycaemic mouse model using a high-fat diet (HFD) combined with 
      an intraperitoneal injection of streptozotocin (STZ) was used to simulate T2DM. 
      The study was done for 15 weeks using seven groups of mice: control group (CG, 
      normal mice, and normal food), non-treated group (BG, diabetic mice, and normal 
      food), positive control group (PG, diabetic mice, and HFD), soybean protein group 
      (SPG, diabetic mice, and HFD), silkworm pupa protein group (SPPG, diabetic mice, 
      and HFD), whey protein group (LPG, diabetic mice, and HFD), and whey protein 
      combined with silkworm pupa protein group (LCSSPG, diabetic mice, and HFD). The 
      plasma levels of total cholesterol (TC), triglycerides (TG), low-density 
      lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) 
      were analyzed on weeks 2, 10, 12, 14, and 15. The concentration of total protein 
      (TP) and albumin (ALB) of the plasma was increased in SPG, SPPG, and PG comparing 
      with BG (p < 0.05). The TC, TG, and LDL-C levels were decreased, and HDL-C level 
      was increased in SPG, PG, SPPG, PG comparing with BG (p < 0.05). Blood glucose 
      (BLG) levels were decreased 47, 34, 24, and 21% in SPG, LCSSPG, SPPG, and PG, 
      respectively. While BLG was not significantly changed (p >/= 0.05) in LG after 5 
      weeks of treatment. Overall, the data suggested that consumption of SP, SPP, 
      LCSSPG Oral-formula may be beneficial for the treatment of T2DM.
CI  - Copyright (c) 2021 Jia, Leng, Cruz, Bao, Bao, Wu, Wang and Ma.
FAU - Jia, Ye
AU  - Jia Y
AD  - Shanghai Ocean University, College of Food Science and Technology, Shanghai, 
      China.
FAU - Leng, Yue
AU  - Leng Y
AD  - Shanghai Ocean University, College of Food Science and Technology, Shanghai, 
      China.
FAU - Cruz, Aliannys Lazara Puente
AU  - Cruz ALP
AD  - Grupo Empresarial de la Industria Alimentaria, Havana, Cuba.
FAU - Bao, Chun Ling
AU  - Bao CL
AD  - East Hospital of Shanghai Sixth People's Hospital, Shanghai, China.
FAU - Bao, Bin
AU  - Bao B
AD  - Shanghai Ocean University, College of Food Science and Technology, Shanghai, 
      China.
FAU - Wu, Wenhui
AU  - Wu W
AD  - Shanghai Ocean University, College of Food Science and Technology, Shanghai, 
      China.
FAU - Wang, Peipei
AU  - Wang P
AD  - Shanghai Ocean University, College of Food Science and Technology, Shanghai, 
      China.
AD  - Tarim University, Xinjiang Production and Construction Corps Key Laboratory of 
      Protection and Utilization of Biological Resourses in Tarim Basin, XinJiang, 
      China.
FAU - Ma, Ming
AU  - Ma M
AD  - Shanghai Ocean University, College of Food Science and Technology, Shanghai, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20210921
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC8490655
OTO - NOTNLM
OT  - oral nutritional formula
OT  - silkworm pupa protein
OT  - soybean protein
OT  - type 2 diabetes mellitus
OT  - whey protein
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/09 06:00
MHDA- 2021/10/09 06:01
PMCR- 2021/01/01
CRDT- 2021/10/08 07:12
PHST- 2021/03/15 00:00 [received]
PHST- 2021/08/05 00:00 [accepted]
PHST- 2021/10/08 07:12 [entrez]
PHST- 2021/10/09 06:00 [pubmed]
PHST- 2021/10/09 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2021.680700 [doi]
PST - epublish
SO  - Front Nutr. 2021 Sep 21;8:680700. doi: 10.3389/fnut.2021.680700. eCollection 
      2021.