PMID- 34621797
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211009
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Association of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio With 
      Diabetic Retinopathy.
PG  - 707008
LID - 10.3389/fcvm.2021.707008 [doi]
LID - 707008
AB  - Background: Chronic inflammation in type 2 diabetes mellitus (T2DM) is an 
      essential contributor to the development of diabetic retinopathy (DR). The 
      monocyte-to-high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel 
      and simple measure related to inflammatory and oxidative stress status. However, 
      little is known regarding the role of the MHR in evaluating the development of 
      DR. Methods: A total of 771 patients with T2DM and 607 healthy controls were 
      enrolled in this cross-sectional study. MHR determination and eye examination 
      were performed. The association of MHR with the prevalence of DR in T2DM patients 
      was analyzed. Results: The MHR in patients with DR was significantly higher than 
      that in both non-DR diabetic patients (P < 0.05) and healthy controls (P < 0.01). 
      No significance was observed in the MHR of different DR severity grades. 
      Moreover, the MHR was similar between patients with non-macular oedema and those 
      with macular oedema. Logistic regression analysis demonstrated that MHR was 
      independently associated with the prevalence of DR in diabetic patients [odds 
      ratio (OR) = 1.438, 95% confidence interval (CI): 1.249-1.655, P < 0.01]. After 
      additional stratification by HbA1c level and diabetic duration, the MHR was still 
      independently associated with the prevalence of DR. Conclusions: Our study 
      suggests that the MHR can be used as a marker to indicate the prevalence of DR in 
      patients with T2DM.
CI  - Copyright (c) 2021 Tang, Tan, Yang, Li, He, Lu, Shi, Zhu, Nie, Li, Mu and Chen.
FAU - Tang, Xixiang
AU  - Tang X
AD  - Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun 
      Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou, China.
AD  - VIP Medical Service Center, The Third Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Tan, Ying
AU  - Tan Y
AD  - Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun 
      Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou, China.
FAU - Yang, Yi
AU  - Yang Y
AD  - Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun 
      Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou, China.
FAU - Li, Mei
AU  - Li M
AD  - Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun 
      Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou, China.
AD  - VIP Medical Service Center, The Third Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - He, Xuemin
AU  - He X
AD  - Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun 
      Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou, China.
FAU - Lu, Yan
AU  - Lu Y
AD  - Department of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Shi, Guojun
AU  - Shi G
AD  - Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun 
      Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou, China.
FAU - Zhu, Yanhua
AU  - Zhu Y
AD  - Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun 
      Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou, China.
FAU - Nie, Yuanpeng
AU  - Nie Y
AD  - Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun 
      Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou, China.
FAU - Li, Haicheng
AU  - Li H
AD  - Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun 
      Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou, China.
FAU - Mu, Panwei
AU  - Mu P
AD  - Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun 
      Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou, China.
FAU - Chen, Yanming
AU  - Chen Y
AD  - Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun 
      Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20210921
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8490616
OTO - NOTNLM
OT  - biomarker
OT  - diabetic retinopathy
OT  - inflammation
OT  - monocyte to high-density lipoprotein cholesterol ratio
OT  - type 2 diabetes
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/09 06:00
MHDA- 2021/10/09 06:01
PMCR- 2021/01/01
CRDT- 2021/10/08 07:12
PHST- 2021/05/08 00:00 [received]
PHST- 2021/08/27 00:00 [accepted]
PHST- 2021/10/08 07:12 [entrez]
PHST- 2021/10/09 06:00 [pubmed]
PHST- 2021/10/09 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.707008 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2021 Sep 21;8:707008. doi: 10.3389/fcvm.2021.707008. 
      eCollection 2021.