PMID- 34621802
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211009
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Clinical Features in Children With Kawasaki Disease Shock Syndrome: A Systematic 
      Review and Meta-Analysis.
PG  - 736352
LID - 10.3389/fcvm.2021.736352 [doi]
LID - 736352
AB  - Objective: This study aimed to identify the clinical features of Kawasaki disease 
      shock syndrome (KDSS) in children. Methods: The case-control studies of KDSS and 
      KD children up until April 30, 2021 were searched in multiple databases. The 
      qualified research were retrieved by manually reviewing the references. Review 
      Manager 5.3 software was used for statistical analysis. Results: The results 
      showed that there was no significant difference in the incidence of male and 
      female in children with KDSS. Children with KDSS compared with non-shocked KD, 
      there were significant difference in age, duration of fever, white blood cell 
      (WBC) count, percentage of neutrophils (NEUT%), platelet count (PLT), c-reactive 
      protein level (CRP), alanine transaminase concentration (ALT), aspartate 
      transaminase concentration (AST), albumin concentration (ALB), sodium 
      concentration (Na), ejection fraction, and length of hospitalization as well as 
      the incidence of coronary artery dilation, coronary artery aneurysm, left 
      ventricular dysfunction, mitral regurgitation, pericardial effusion, initial 
      diagnosis of KD, intravenous immunoglobulin (IVIG) resistance and receiving 
      second dose of IVIG, vasoactive drugs, hormones, and albumin. In contrast, there 
      was no difference in the hemoglobin concentration, erythrocyte sedimentation 
      rate, and the incidence of conjunctival injection, oropharyngeal change, 
      polymorphous rash, extremity change, and incomplete KD. Conclusion: Current 
      evidence suggested that the children with KDSS had more severe indicators of 
      inflammation and more cardiac abnormalities. These patients were resistant to 
      immunoglobulin treatment and required extra anti-inflammatory treatment. 
      Systematic Review Registration: PROSPERO registration number CRD42021241207.
CI  - Copyright (c) 2021 Zheng, Huang, Wang, Tang, Chen, Li, Li, Zang, Wang, Wang, Ma and 
      Sun.
FAU - Zheng, Zhimin
AU  - Zheng Z
AD  - College of Clinical Medicine, Changchun University of Chinese Medicine, 
      Changchun, China.
FAU - Huang, Yanzhi
AU  - Huang Y
AD  - Jilin Children's Medical Center, Children's Hospital of Changchun, Changchun, 
      China.
FAU - Wang, Zhiyi
AU  - Wang Z
AD  - College of Clinical Medicine, Changchun University of Chinese Medicine, 
      Changchun, China.
FAU - Tang, Jia
AU  - Tang J
AD  - College of Clinical Medicine, Changchun University of Chinese Medicine, 
      Changchun, China.
FAU - Chen, Xiaoqian
AU  - Chen X
AD  - College of Clinical Medicine, Changchun University of Chinese Medicine, 
      Changchun, China.
FAU - Li, Ying
AU  - Li Y
AD  - College of Clinical Medicine, Changchun University of Chinese Medicine, 
      Changchun, China.
FAU - Li, Meng
AU  - Li M
AD  - College of Clinical Medicine, Changchun University of Chinese Medicine, 
      Changchun, China.
FAU - Zang, Chengye
AU  - Zang C
AD  - College of Clinical Medicine, Changchun University of Chinese Medicine, 
      Changchun, China.
FAU - Wang, Yibo
AU  - Wang Y
AD  - Jilin Children's Medical Center, Children's Hospital of Changchun, Changchun, 
      China.
FAU - Wang, Liwu
AU  - Wang L
AD  - Jilin Children's Medical Center, Children's Hospital of Changchun, Changchun, 
      China.
FAU - Ma, Yingwei
AU  - Ma Y
AD  - Jilin Children's Medical Center, Children's Hospital of Changchun, Changchun, 
      China.
FAU - Sun, Liwei
AU  - Sun L
AD  - Jilin Children's Medical Center, Children's Hospital of Changchun, Changchun, 
      China.
LA  - eng
PT  - Systematic Review
DEP - 20210921
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8491834
OTO - NOTNLM
OT  - Kawasaki disease
OT  - Kawasaki disease shock syndrome
OT  - clinical feature
OT  - meta-analysis
OT  - shock
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/10/09 06:00
MHDA- 2021/10/09 06:01
PMCR- 2021/01/01
CRDT- 2021/10/08 07:12
PHST- 2021/07/06 00:00 [received]
PHST- 2021/08/13 00:00 [accepted]
PHST- 2021/10/08 07:12 [entrez]
PHST- 2021/10/09 06:00 [pubmed]
PHST- 2021/10/09 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.736352 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2021 Sep 21;8:736352. doi: 10.3389/fcvm.2021.736352. 
      eCollection 2021.