PMID- 34622023
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 2398-8835 (Electronic)
IS  - 2398-8835 (Linking)
VI  - 4
IP  - 4
DP  - 2021 Dec
TI  - The association of oxidative stress biomarkers with type 2 diabetes mellitus: A 
      systematic review and meta-analysis.
PG  - e389
LID - 10.1002/hsr2.389 [doi]
LID - e389
AB  - BACKGROUND AND AIMS: Oxidative stress plays a major role in the development of 
      type 2 diabetes mellitus (T2DM). However, there were controversial outcomes in 
      the literature between the association of oxidative stress biomarkers and T2DM. 
      The purpose of this systematic review and meta-analysis was to critically examine 
      the association of oxidative stress biomarkers with T2DM. METHODS: We 
      systematically searched different electronic databases including PubMed/Medline, 
      EMBASE, ScienceDirect, Web of Science, and Cochrane Library to find the relevant 
      studies up to May 2021. The pooled standard mean difference (SMD) with a 95% 
      confidence interval (CI) was used to define the variation between the study 
      groups. RESULTS: A total of 22 case-control studies with 2853 subjects (1667 
      diabetic patients and 1186 healthy controls) were found to be eligible for this 
      meta-analysis. The pooled results of meta-analysis showed a significant 
      difference in the levels malondialdehyde (SMD [95% CI]: 2.27 [1.62, 2.91]), 
      nitric oxide (SMD [95% CI]: 1.40 [0.00, 2.81]), glutathione (SMD [95% CI]: -1.76 
      [-2.94, -0.59]), and total antioxidant status (SMD [95% CI]: -1.40 [-2.28, 
      -0.51]) between the patient group and healthy subjects, whereas no significant 
      difference was observed in the superoxide dismutase levels (SMD [95% CI]: -1.20 
      [-2.55, 0.15]) and glutathione peroxidase levels (SMD [95% CI]: 0.07 [-2.80, 
      2.94]). CONCLUSION: The present analysis suggests that oxidative stress might 
      have a potential role in the pathogenesis of T2DM in humans. However, further 
      studies should be needed to elucidate the possible mechanism and strengthen this 
      evidence.
CI  - (c) 2021 The Authors. Health Science Reports published by Wiley Periodicals LLC.
FAU - Banik, Sujan
AU  - Banik S
AUID- ORCID: 0000-0001-9639-6836
AD  - Department of Pharmacy Noakhali Science and Technology University Noakhali 
      Bangladesh.
FAU - Ghosh, Antara
AU  - Ghosh A
AUID- ORCID: 0000-0003-2349-1642
AD  - Department of Pharmacy Noakhali Science and Technology University Noakhali 
      Bangladesh.
LA  - eng
PT  - Journal Article
DEP - 20211001
PL  - United States
TA  - Health Sci Rep
JT  - Health science reports
JID - 101728855
PMC - PMC8485598
OTO - NOTNLM
OT  - antioxidant
OT  - malondialdehyde
OT  - meta-analysis
OT  - oxidative stress
OT  - type 2 diabetes mellitus
COIS- We have declared that we have no competing interests.
EDAT- 2021/10/09 06:00
MHDA- 2021/10/09 06:01
PMCR- 2021/10/01
CRDT- 2021/10/08 07:14
PHST- 2021/05/27 00:00 [received]
PHST- 2021/07/16 00:00 [revised]
PHST- 2021/08/02 00:00 [accepted]
PHST- 2021/10/08 07:14 [entrez]
PHST- 2021/10/09 06:00 [pubmed]
PHST- 2021/10/09 06:01 [medline]
PHST- 2021/10/01 00:00 [pmc-release]
AID - HSR2389 [pii]
AID - 10.1002/hsr2.389 [doi]
PST - epublish
SO  - Health Sci Rep. 2021 Oct 1;4(4):e389. doi: 10.1002/hsr2.389. eCollection 2021 
      Dec.