PMID- 34623100
OWN - NLM
STAT- MEDLINE
DCOM- 20211217
LR  - 20211217
IS  - 1538-6899 (Electronic)
IS  - 1080-2371 (Linking)
VI  - 27
IP  - 4
DP  - 2021 Aug 1
TI  - Neurologic Complications of Human Immunodeficiency Virus.
PG  - 963-991
LID - 10.1212/CON.0000000000001035 [doi]
AB  - PURPOSE OF REVIEW: This article reviews the neurologic complications associated 
      with human immunodeficiency virus (HIV) infection. RECENT FINDINGS: Neurologic 
      complications of HIV may be caused by direct virally mediated pathology, 
      immune-mediated phenomena in response to viral infection, or opportunistic 
      infections secondary to depletion of lymphocytes. These neurologic disorders may 
      be influenced by the degree of immunosuppression (ie, CD4+ T-cell lymphocyte 
      count) and stage of infection (early versus late), as well as use of 
      antiretroviral therapy, and may manifest as a variety of central and peripheral 
      neurologic syndromes, including the more commonly encountered HIV-associated 
      cognitive disorders and length-dependent sensorimotor polyneuropathy, 
      respectively. Immune dysregulation underlies the majority of these neurologic 
      phenomena, as well as other HIV-associated conditions including immune 
      reconstitution inflammatory syndrome (IRIS), CD8 lymphocytosis, and potentially 
      the development of compartmentalized infection within the CSF, also referred to 
      as CSF escape. SUMMARY: This article reviews a spectrum of clinical syndromes and 
      related neuropathologic states associated with HIV infection.
CI  - Copyright (c) 2021 American Academy of Neurology.
FAU - Grill, Marie F
AU  - Grill MF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Continuum (Minneap Minn)
JT  - Continuum (Minneapolis, Minn.)
JID - 9509333
SB  - IM
MH  - HIV
MH  - *HIV Infections/complications/drug therapy
MH  - Humans
MH  - *Immune Reconstitution Inflammatory Syndrome
MH  - *Nervous System Diseases/diagnosis/etiology
EDAT- 2021/10/09 06:00
MHDA- 2021/12/18 06:00
CRDT- 2021/10/08 10:36
PHST- 2021/10/08 10:36 [entrez]
PHST- 2021/10/09 06:00 [pubmed]
PHST- 2021/12/18 06:00 [medline]
AID - 00132979-202108000-00010 [pii]
AID - 10.1212/CON.0000000000001035 [doi]
PST - ppublish
SO  - Continuum (Minneap Minn). 2021 Aug 1;27(4):963-991. doi: 
      10.1212/CON.0000000000001035.