PMID- 34623294
OWN - NLM
STAT- MEDLINE
DCOM- 20220107
LR  - 20220107
IS  - 1308-4488 (Electronic)
IS  - 1016-5169 (Linking)
VI  - 49
IP  - 7
DP  - 2021 Oct
TI  - The relationship between plasma proadrenomedullin level and severity of the 
      disease in patients with isolated rheumatic mitral stenosis.
PG  - 522-532
LID - 10.5543/tkda.2021.39232 [doi]
AB  - OBJECTIVE: In this study, we aimed to determine the plasma proadrenomedullin 
      (ProADM) levels in patients with rheumatic mitral stenosis (MS), to evaluate the 
      relationship between ProADM levels and the echocardiographic parameters that 
      represent the severity of stenosis and symptoms, and to compare the ProADM and 
      N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, which is a 
      well-known marker for rheumatic MS. METHODS: Our study included 53 consecutive 
      patients with isolated rheumatic MS and 45 volunteers with similar age and gender 
      features. Patients with MS were divided into two groups based on the presence of 
      an indication for intervention. Detailed echocardiographic examinations were 
      performed on all participants, and blood samples were collected to detect the 
      NT-proBNP and ProADM levels. RESULTS: NT-proBNP and ProADM levels were 
      significantly higher in the rheumatic MS group compared with the control group. 
      In rheumatic MS groups, patients with an indication for intervention had higher 
      levels of NT-proBNP and ProADM compared with patients without an indication for 
      intervention. Moreover, NT-proBNP and ProADM levels were found to be 
      significantly correlated with echocardiographic parameters, which revealed the 
      severity of stenosis in various degrees. Both parameters increased as the New 
      York Heart Association (NYHA) class increased, and this increase had a 
      statistical significance. Additionally, the cut-off values of both parameters 
      (NT-proBNP: 119.9 pg/mL, ProADM: 6.15 nmol/L) could detect patients with an 
      indication for intervention with high sensitivity and specificity rates. 
      NT-proBNP was found to be slightly more effective in this regard. CONCLUSION: The 
      increased NT-proBNP and ProADM levels in patients with isolated rheumatic MS can 
      help clinicians in distinguishing patients with an indication for intervention by 
      providing additional information to echocardiography.
FAU - Demir, Ali Riza
AU  - Demir AR
AD  - Department of Cardiology, University of Health Science, Istanbul Mehmet Akif 
      Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Cetin, Ilyas
AU  - Cetin I
AD  - Department of Cardiology, Basaksehir Cam and Sakura City Hospital, Istanbul, 
      Turkey.
FAU - Kalkan, Ali Kemal
AU  - Kalkan AK
AD  - Department of Cardiology, University of Health Science, Istanbul Mehmet Akif 
      Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Avci, Yalcin
AU  - Avci Y
AD  - Department of Cardiology, University of Health Science, Istanbul Mehmet Akif 
      Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Altunova, Mehmet
AU  - Altunova M
AD  - Department of Cardiology, Idil State Hospital, Sirnak, Turkey.
FAU - Uygur, Begum
AU  - Uygur B
AD  - Department of Cardiology, University of Health Science, Istanbul Mehmet Akif 
      Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Yilmaz, Emre
AU  - Yilmaz E
AD  - Department of Cardiology, Gorele State Hospital, Giresun, Turkey.
FAU - Erturk, Mehmet
AU  - Erturk M
AD  - Department of Cardiology, University of Health Science, Istanbul Mehmet Akif 
      Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 
      Istanbul, Turkey.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Turkey
TA  - Turk Kardiyol Dern Ars
JT  - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
JID - 9426239
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (Protein Precursors)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 0 (proadrenomedullin)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 148498-78-6 (Adrenomedullin)
SB  - IM
CIN - Turk Kardiyol Dern Ars. 2021 Dec;49(8):698. PMID: 34881713
MH  - Adrenomedullin/*blood
MH  - Adult
MH  - Biomarkers/blood
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Mitral Valve Stenosis/blood/*physiopathology
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Protein Precursors/*blood
MH  - Rheumatic Heart Disease/blood/*physiopathology
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 2021/10/09 06:00
MHDA- 2022/01/08 06:00
CRDT- 2021/10/08 12:16
PHST- 2021/10/08 12:16 [entrez]
PHST- 2021/10/09 06:00 [pubmed]
PHST- 2022/01/08 06:00 [medline]
AID - 10.5543/tkda.2021.39232 [doi]
PST - ppublish
SO  - Turk Kardiyol Dern Ars. 2021 Oct;49(7):522-532. doi: 10.5543/tkda.2021.39232.