PMID- 34624103
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20221221
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 48
IP  - 2
DP  - 2022 Mar 1
TI  - Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI 
      Research Collaboration.
PG  - 514-523
LID - 10.1093/schbul/sbab122 [doi]
AB  - Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity 
      from nonpsychotic major depression (NPMD). However, neurobiological evidence 
      supporting this notion is scarce. The aim of this study is to identify gray 
      matter volume (GMV) differences between PMD and NPMD and their longitudinal 
      change following electroconvulsive therapy (ECT). Structural magnetic resonance 
      imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research 
      Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71.7 in 
      PMD and 70.2 in NPMD) were analyzed. All participants underwent MRI before and 
      after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between 
      PMD and NPMD were conducted at both time points. Second, in a flexible factorial 
      model, a main effect of time and a group-by-time interaction were examined to 
      identify longitudinal effects of ECT on GMV and longitudinal differential effects 
      of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower 
      GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower 
      GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a 
      significant main effect of time on GMV in several brain regions in both PMD and 
      NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC 
      was consistently identified in PMD, suggesting this may be a trait-like neural 
      substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT 
      response in PMD, and further investigation is needed.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      Maryland Psychiatric Research Center.
FAU - Takamiya, Akihiro
AU  - Takamiya A
AD  - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
AD  - Department of Neurosciences and Neuropsychiatry, Leuven Brain Institute, KU 
      Leuven, Leuven, Belgium.
FAU - Dols, Annemiek
AU  - Dols A
AD  - GGZ inGeest Specialized Mental Health Care, Amsterdam, the Netherlands.
AD  - Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije 
      Universiteit Amsterdam, Amsterdam, the Netherlands.
FAU - Emsell, Louise
AU  - Emsell L
AD  - Department of Neurosciences and Neuropsychiatry, Leuven Brain Institute, KU 
      Leuven, Leuven, Belgium.
FAU - Abbott, Christopher
AU  - Abbott C
AD  - Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA.
FAU - Yrondi, Antoine
AU  - Yrondi A
AD  - Service de Psychiatrie et de Psychologie Medicale, Centre Expert Depression 
      Resistante FondaMental, CHU Toulouse, Hospital Purpan, ToNIC, Toulouse 
      NeuroImaging Center, Universite de Toulouse, Inserm, UPS, Toulouse, France.
FAU - Soriano Mas, Carles
AU  - Soriano Mas C
AD  - Department of Psychiatry, Bellvitge Biomedical Research Institute-IDIBELL, 
      Barcelona, Spain.
AD  - CIBERSAM, Carlos III Health Institute, Madrid, Spain.
AD  - Department of Psychobiology and Methodology in Health Sciences, Universitat 
      Autonoma de Barcelona, Barcelona, Spain.
FAU - Jorgensen, Martin Balslev
AU  - Jorgensen MB
AD  - Psychiatric Centre Copenhagen, Copenhagen, Denmark.
AD  - Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
FAU - Nordanskog, Pia
AU  - Nordanskog P
AD  - Department of Clinical and Experimental Medicine, Center for Social and Affective 
      Neuroscience (CSAN), Linkoping University, Linkoping, Sweden.
FAU - Rhebergen, Didi
AU  - Rhebergen D
AD  - Mental Health Care Institute, GGZ Centraal, Amersfoort, the Netherlands.
FAU - van Exel, Eric
AU  - van Exel E
AD  - GGZ inGeest Specialized Mental Health Care, Amsterdam, the Netherlands.
AD  - Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije 
      Universiteit Amsterdam, Amsterdam, the Netherlands.
FAU - Oudega, Mardien L
AU  - Oudega ML
AD  - GGZ inGeest Specialized Mental Health Care, Amsterdam, the Netherlands.
AD  - Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Vrije 
      Universiteit Amsterdam, Amsterdam, the Netherlands.
FAU - Bouckaert, Filip
AU  - Bouckaert F
AD  - Department of Neurosciences and Neuropsychiatry, Leuven Brain Institute, KU 
      Leuven, Leuven, Belgium.
FAU - Vandenbulcke, Mathieu
AU  - Vandenbulcke M
AD  - Department of Neurosciences and Neuropsychiatry, Leuven Brain Institute, KU 
      Leuven, Leuven, Belgium.
FAU - Sienaert, Pascal
AU  - Sienaert P
AD  - Academic Center for ECT and Neurostimulation (AcCENT), University Psychiatric 
      Center (UPC)-KU Leuven, Kortenberg, Belgium.
FAU - Peran, Patrice
AU  - Peran P
AD  - ToNIC, Toulouse NeuroImaging Center, Universite de Toulouse, Inserm, UPS, 
      Toulouse, France.
FAU - Cano, Marta
AU  - Cano M
AD  - CIBERSAM, Carlos III Health Institute, Madrid, Spain.
AD  - Mental Health Department, Unitat de Neurociencia Traslacional, Parc Tauli 
      University Hospital, Institut d'Investigacio i Innovacio Sanitaria Parc Tauli 
      (I3PT), Barcelona, Spain.
AD  - Department of Psychobiology and Methodology of Health Sciences, Universitat 
      Autonoma de Barcelona, Barcelona, Spain.
FAU - Cardoner, Narcis
AU  - Cardoner N
AD  - Mental Health Department, Unitat de Neurociencia Traslacional, Parc Tauli 
      University Hospital, Institut d'Investigacio i Innovacio Sanitaria Parc Tauli 
      (I3PT), Barcelona, Spain.
FAU - Jorgensen, Anders
AU  - Jorgensen A
AD  - Psychiatric Centre Copenhagen, Copenhagen, Denmark.
AD  - Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
FAU - Paulson, Olaf B
AU  - Paulson OB
AD  - Neurobiological Research Unit, Rigshospitalet, Copenhagen, Denmark.
FAU - Hamilton, Paul
AU  - Hamilton P
AD  - Department of Biomedical and Clinical Sciences, Center for Social and Affective 
      Neuroscience (CSAN), Linkoping University, Linkoping, Sweden.
FAU - Kampe, Robin
AU  - Kampe R
AD  - Department of Biomedical and Clinical Sciences, Center for Social and Affective 
      Neuroscience (CSAN), Linkoping University, Linkoping, Sweden.
FAU - Bruin, Willem
AU  - Bruin W
AD  - Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the 
      Netherlands.
FAU - Bartsch, Hauke
AU  - Bartsch H
AD  - Department of Radiology, Mohn Medical Imaging and Visualization Centre, Haukeland 
      University Hospital, Bergen, Norway.
AD  - Department of Research and Innovation, Haukeland University Hospital, Bergen, 
      Norway.
AD  - Department of Informatics, University of Bergen, Bergen, Norway.
FAU - Ousdal, Olga Therese
AU  - Ousdal OT
AD  - Department of Radiology, Mohn Medical Imaging and Visualization Centre, Haukeland 
      University Hospital, Bergen, Norway.
AD  - Faculty of Psychology, Centre for Crisis Psychology, University of Bergen, 
      Bergen, Norway.
FAU - Kessler, Ute
AU  - Kessler U
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway.
AD  - Division of Psychiatry, NORMENT, Haukeland University Hospital, Bergen, Norway.
FAU - van Wingen, Guido
AU  - van Wingen G
AD  - Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the 
      Netherlands.
FAU - Oltedal, Leif
AU  - Oltedal L
AD  - Department of Radiology, Mohn Medical Imaging and Visualization Centre, Haukeland 
      University Hospital, Bergen, Norway.
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway.
FAU - Kishimoto, Taishiro
AU  - Kishimoto T
AD  - Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
LA  - eng
GR  - R01 MH111826/MH/NIMH NIH HHS/United States
GR  - R61 MH125126/MH/NIMH NIH HHS/United States
GR  - U01 MH111826/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Cortical Thickness
MH  - Depression/*physiopathology
MH  - Electroconvulsive Therapy/methods/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods/statistics & numerical data
MH  - Male
MH  - Middle Aged
PMC - PMC8886602
OTO - NOTNLM
OT  - depression
OT  - gray matter volume
OT  - magnetic resonance imaging
OT  - medial prefrontal cortex
OT  - psychosis
EDAT- 2021/10/09 06:00
MHDA- 2022/03/15 06:00
PMCR- 2021/10/08
CRDT- 2021/10/08 17:17
PHST- 2021/10/09 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/10/08 17:17 [entrez]
PHST- 2021/10/08 00:00 [pmc-release]
AID - 6384729 [pii]
AID - sbab122 [pii]
AID - 10.1093/schbul/sbab122 [doi]
PST - ppublish
SO  - Schizophr Bull. 2022 Mar 1;48(2):514-523. doi: 10.1093/schbul/sbab122.