PMID- 34625179
OWN - NLM
STAT- MEDLINE
DCOM- 20220110
LR  - 20220110
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Linking)
VI  - 160
IP  - 4
DP  - 2021 Oct
TI  - Oral Positive Expiratory Pressure Device for Excessive Dynamic Airway Collapse 
      Caused by Emphysema.
PG  - e333-e337
LID - S0012-3692(21)00870-9 [pii]
LID - 10.1016/j.chest.2021.04.059 [doi]
AB  - Excessive dynamic airway collapse (EDAC) contributes to breathlessness and 
      reduced quality of life in individuals with emphysema. We tested a novel, 
      portable, oral positive expiratory pressure (o-PEP) device in a patient with 
      emphysema and EDAC. MRI revealed expiratory tracheal narrowing to 80 mm(2) that 
      increased to 170 mm(2) with the o-PEP device. After 2-weeks use of the o-PEP 
      device for 33% to 66% of activities, breathlessness, quality of life, and 
      exertional dyspnea improved compared with minimal clinically important 
      differences (MCID): University of California-San Diego Shortness of Breath 
      questionnaire score declined 69 to 42 (MCID, >/=5), St. George's Respiratory 
      Questionnaire score decreased 71 to 27 (MCID, >/=4), and before and after the 
      6-minute walk test Borg score difference improved from Delta3 to Delta2 (MCID, >/=1). 
      During the 6-minute walk test on room air without the use of the o-PEP device, 
      oxyhemoglobin saturation declined 91% to 83%; whereas, with the o-PEP device, the 
      nadir was 90%. Use of the o-PEP device reduced expiratory central airway collapse 
      and improved dyspnea, quality of life, and exertional desaturation in a patient 
      with EDAC and emphysema.
CI  - Copyright (c) 2021 American College of Chest Physicians. All rights reserved.
FAU - Zafar, Muhammad Ahsan
AU  - Zafar MA
AD  - Department of Internal Medicine, Division of Pulmonary and Critical Care 
      Medicine, University of Cincinnati College of Medicine, Cincinnati, OH. 
      Electronic address: zafarmd@ucmail.uc.edu.
FAU - Sengupta, Ruchira
AU  - Sengupta R
AD  - Department of Internal Medicine, Division of Pulmonary and Critical Care 
      Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.
FAU - Bates, Alister
AU  - Bates A
AD  - Department of Pediatrics, University of Cincinnati College of Medicine, 
      Cincinnati, OH; Division of Pulmonary Medicine & Department of Radiology, Center 
      for Pulmonary Imaging Research, Cincinnati Children's Hospital, Cincinnati, OH.
FAU - Woods, Jason C
AU  - Woods JC
AD  - Department of Pediatrics, University of Cincinnati College of Medicine, 
      Cincinnati, OH; Division of Pulmonary Medicine & Department of Radiology, Center 
      for Pulmonary Imaging Research, Cincinnati Children's Hospital, Cincinnati, OH.
FAU - Radchenko, Christopher
AU  - Radchenko C
AD  - Department of Internal Medicine, Division of Pulmonary and Critical Care 
      Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.
FAU - McCormack, Francis X
AU  - McCormack FX
AD  - Department of Internal Medicine, Division of Pulmonary and Critical Care 
      Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.
FAU - Panos, Ralph J
AU  - Panos RJ
AD  - Department of Internal Medicine, Division of Pulmonary and Critical Care 
      Medicine, University of Cincinnati College of Medicine, Cincinnati, OH; 
      Department of Medicine, Veterans Affairs Medical Center, Cincinnati, OH.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (Oxyhemoglobins)
RN  - Neuraminidase deficiency with beta-galactosidase deficiency
SB  - IM
MH  - Adult
MH  - Bronchiectasis/physiopathology/*rehabilitation
MH  - Bronchoscopy
MH  - Continuous Positive Airway Pressure
MH  - Dyspnea/physiopathology/*rehabilitation
MH  - Equipment Design
MH  - *Equipment and Supplies
MH  - Female
MH  - Humans
MH  - Lysosomal Storage Diseases/physiopathology/*rehabilitation
MH  - Magnetic Resonance Imaging
MH  - Oximetry
MH  - Oxyhemoglobins
MH  - *Pressure
MH  - Printing, Three-Dimensional
MH  - Pulmonary Emphysema/physiopathology/*rehabilitation
MH  - Quality of Life
MH  - *Respiratory Mechanics
MH  - Trachea/physiopathology
MH  - Walk Test
OTO - NOTNLM
OT  - EDAC
OT  - airway collapse
OT  - emphysema
OT  - positive expiratory pressure
EDAT- 2021/10/10 06:00
MHDA- 2022/01/11 06:00
CRDT- 2021/10/09 05:30
PHST- 2020/12/10 00:00 [received]
PHST- 2021/04/06 00:00 [revised]
PHST- 2021/04/22 00:00 [accepted]
PHST- 2021/10/09 05:30 [entrez]
PHST- 2021/10/10 06:00 [pubmed]
PHST- 2022/01/11 06:00 [medline]
AID - S0012-3692(21)00870-9 [pii]
AID - 10.1016/j.chest.2021.04.059 [doi]
PST - ppublish
SO  - Chest. 2021 Oct;160(4):e333-e337. doi: 10.1016/j.chest.2021.04.059.