PMID- 34625351
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1532-8422 (Electronic)
IS  - 1053-0770 (Linking)
VI  - 36
IP  - 1
DP  - 2022 Jan
TI  - Incidence and Predictive Factors of Acute Kidney Injury After Off-pump Lung 
      Transplantation.
PG  - 93-99
LID - S1053-0770(21)00835-1 [pii]
LID - 10.1053/j.jvca.2021.09.021 [doi]
AB  - OBJECTIVES: To determine the incidence and predictive factors of acute kidney 
      injury (AKI) after off-pump lung transplantation. DESIGN: A retrospective cohort 
      study. SETTING: The operating room and intensive care unit. PARTICIPANTS: Adult 
      patients who underwent lung transplant without cardiopulmonary bypass or 
      extracorporeal membrane oxygenator between 2006 and 2016 at the Vanderbilt 
      University Medical Center. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: 
      The presence of postoperative AKI was assessed by the Kidney Disease: Improving 
      Global Outcomes criteria in the first seven postoperative days. Multivariate 
      logistic regression analysis was used to determine the independent predictive 
      factors of AKI. One hundred forty-eight patients were included in the final 
      analysis, of whom 63 (42.6%) subsequently developed AKI: 43 (29.0%) stage 1, ten 
      (6.8%) stage 2, and ten (6.8%) stage 3. Patients who had AKI had a longer 
      hospital length of stay (12 days [interquartile range (IQR): 10-17] vs ten days 
      [IQR: 8-12], p < 0.001). For every one-year increase in age, the odds of AKI 
      decreased by 8% (odds ratio [OR] 0.92, 95% confidence interval [CI]: 0.87-0.98, 
      p = 0.008). The odds of having AKI in patients with bilateral lung transplant was 
      lower than patients with unilateral transplant (OR 0.09, 95% CI: 0.01-0.63, 
      p = 0.015). Additionally, a diagnosis of chronic obstructive pulmonary disease 
      increased the odds of AKI by four-fold compared with a diagnosis of idiopathic 
      pulmonary fibrosis (OR 4.73, 95% CI: 1.44-15.56, p = 0.011). CONCLUSIONS: AKI is 
      a common complication after off-pump lung transplantation and is associated with 
      increased hospital length of stay. Younger age, unilateral lung transplant, and 
      diagnosis of chronic obstructive pulmonary disease are independently associated 
      with AKI.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Chaudhry, Rabail
AU  - Chaudhry R
AD  - Department of Anesthesiology, The University of Texas Health Science Center at 
      Houston, McGovern Medical School, Houston, TX.
FAU - Wanderer, Jonathan P
AU  - Wanderer JP
AD  - Department of Anesthesia, Vanderbilt University School of Medicine, Nashville, 
      TN.
FAU - Mubashir, Talha
AU  - Mubashir T
AD  - Department of Anesthesiology, The University of Texas Health Science Center at 
      Houston, McGovern Medical School, Houston, TX.
FAU - Kork, Felix
AU  - Kork F
AD  - Department of Anesthesiology, Medical Faculty, RWTH Aachen University, Aachen, 
      Germany.
FAU - Morse, Jennifer
AU  - Morse J
AD  - Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, 
      TN.
FAU - Waseem, Rida
AU  - Waseem R
AD  - Department of Anesthesia and Pain Management, Toronto Western Hospital, 
      University Health Network, University of Toronto, Toronto, ON, Canada.
FAU - Zaki, John F
AU  - Zaki JF
AD  - Department of Anesthesiology, The University of Texas Health Science Center at 
      Houston, McGovern Medical School, Houston, TX.
FAU - Shaw, Andrew D
AU  - Shaw AD
AD  - Department of Intensive Care and Resuscitation, Cleveland Clinic, Cleveland, OH.
FAU - Eltzschig, Holger K
AU  - Eltzschig HK
AD  - Department of Anesthesiology, The University of Texas Health Science Center at 
      Houston, McGovern Medical School, Houston, TX.
FAU - Liang, Yafen
AU  - Liang Y
AD  - Department of Anesthesiology, The University of Texas Health Science Center at 
      Houston, McGovern Medical School, Houston, TX. Electronic address: 
      yafen.liang@uth.tmc.edu.
LA  - eng
PT  - Journal Article
DEP - 20210917
PL  - United States
TA  - J Cardiothorac Vasc Anesth
JT  - Journal of cardiothoracic and vascular anesthesia
JID - 9110208
SB  - IM
CIN - J Cardiothorac Vasc Anesth. 2022 Jan;36(1):100-102. PMID: 34952670
MH  - *Acute Kidney Injury/diagnosis/epidemiology/etiology
MH  - Humans
MH  - Incidence
MH  - *Lung Transplantation/adverse effects
MH  - Postoperative Complications/diagnosis/epidemiology/etiology
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - acute kidney injury
OT  - incidence
OT  - lung transplant
OT  - off-pump
OT  - outcome
OT  - predictive factors
COIS- Conflict of Interest The authors declare no competing interests.
EDAT- 2021/10/10 06:00
MHDA- 2022/02/01 06:00
CRDT- 2021/10/09 05:36
PHST- 2021/07/01 00:00 [received]
PHST- 2021/09/01 00:00 [revised]
PHST- 2021/09/13 00:00 [accepted]
PHST- 2021/10/10 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/10/09 05:36 [entrez]
AID - S1053-0770(21)00835-1 [pii]
AID - 10.1053/j.jvca.2021.09.021 [doi]
PST - ppublish
SO  - J Cardiothorac Vasc Anesth. 2022 Jan;36(1):93-99. doi: 
      10.1053/j.jvca.2021.09.021. Epub 2021 Sep 17.