PMID- 34625854
OWN - NLM
STAT- MEDLINE
DCOM- 20240725
LR  - 20240725
IS  - 1436-5073 (Electronic)
IS  - 0026-3672 (Linking)
VI  - 188
IP  - 11
DP  - 2021 Oct 8
TI  - 3D, large-area NiCo(2)O(4) microflowers as a highly stable substrate for rapid 
      and trace level detection of flutamide in biofluids via surface-enhanced Raman 
      scattering (SERS).
PG  - 371
LID - 10.1007/s00604-021-05034-2 [doi]
AB  - A one-pot hydrothermal synthesis of three-dimensional (3D), large-area, 
      bimetallic oxide NiCo(2)O(4) (NCO) microflowers has been developed as a novel 
      substrate for surface-enhanced Raman scattering (SERS) detection of flutamide in 
      biological fluids. The 3D flower-like morphology of the NCO is observed via FESEM 
      micrographs, while the orthorhombic phase formation is confirmed through XRD 
      spectra. Due to the presence of multiple coordination cations of the 3D NCO 
      microflowers (such as Ni(2+) and Co(2+)), the high surface area and surface 
      roughness, the NCO-modified indium tin oxide (NCO/ITO) SERS substrate exhibits a 
      linear detection range from 0.5-500 nM with a low limit of detection (LOD) of 
      0.1 nM. The SERS substrate provides a high enhancement factor of 1.864 x 10(6) 
      with an accumulation time of 30 s using a laser source of lambda = 532 nm, which can 
      be ascribed to the excellent and rapid interaction between the flutamide molecule 
      and the NCO microflower substrate that leads to photoinduced charge transfer 
      (PICT) resonance. The NCO/ITO substrate exhibits excellent homogeneity and high 
      chemical stability. Besides, the substrate displays an excellent selectivity to 
      flutamide molecules in the existence of other metabolites such as urea, ascorbic 
      acid (AA), glucose, NaCl, KCl, CaCl(2), and hydroxyflutamide. The NCO/ITO 
      substrate is successful in the trace-level detection of flutamide in simulated 
      blood serum samples. The strategy outlined here presents a novel strategy for the 
      efficacy of transition metal oxides (TMOs) based electrodes useful for a wide 
      variety of bioanalytical applications.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, 
      part of Springer Nature.
FAU - Durai, Lignesh
AU  - Durai L
AD  - Department of Electrical Engineering, Indian Institute of Technology, Hyderabad, 
      502285, India.
FAU - Badhulika, Sushmee
AU  - Badhulika S
AUID- ORCID: 0000-0003-3237-3031
AD  - Department of Electrical Engineering, Indian Institute of Technology, Hyderabad, 
      502285, India. sbadh@iith.ac.in.
LA  - eng
GR  - SB/WEA-03/2017/science and engineering research board/
PT  - Journal Article
DEP - 20211008
PL  - Austria
TA  - Mikrochim Acta
JT  - Mikrochimica acta
JID - 7808782
RN  - 76W6J0943E (Flutamide)
RN  - 3G0H8C9362 (Cobalt)
RN  - 0 (Oxides)
RN  - 0 (Tin Compounds)
RN  - 71243-84-0 (indium tin oxide)
MH  - *Spectrum Analysis, Raman/methods
MH  - *Flutamide/blood/chemistry
MH  - *Limit of Detection
MH  - Humans
MH  - *Cobalt/chemistry
MH  - *Oxides/chemistry
MH  - Tin Compounds/chemistry
MH  - Surface Properties
MH  - Metal Nanoparticles/chemistry
OTO - NOTNLM
OT  - Bimetallic-oxide
OT  - Blood serum analysis
OT  - Flutamide
OT  - Microflower substrate; NiCo2O4
OT  - Surface-enhanced Raman spectroscopy (SERS)
EDAT- 2021/10/10 06:00
MHDA- 2022/01/29 06:00
CRDT- 2021/10/09 06:26
PHST- 2021/07/05 00:00 [received]
PHST- 2021/09/18 00:00 [accepted]
PHST- 2021/10/09 06:26 [entrez]
PHST- 2021/10/10 06:00 [pubmed]
PHST- 2022/01/29 06:00 [medline]
AID - 10.1007/s00604-021-05034-2 [pii]
AID - 10.1007/s00604-021-05034-2 [doi]
PST - epublish
SO  - Mikrochim Acta. 2021 Oct 8;188(11):371. doi: 10.1007/s00604-021-05034-2.