PMID- 34627361 OWN - NLM STAT- MEDLINE DCOM- 20211028 LR - 20211028 IS - 1758-9193 (Electronic) VI - 13 IP - 1 DP - 2021 Oct 9 TI - Characteristics of behavioral symptoms in right-sided predominant semantic dementia and their impact on caregiver burden: a cross-sectional study. PG - 166 LID - 10.1186/s13195-021-00908-2 [doi] LID - 166 AB - BACKGROUND: This study aimed to clarify the neuropsychiatric symptoms of right-sided predominant semantic dementia (SD-R) by comparing them with those of behavioral variant frontotemporal dementia (bvFTD), left-sided predominant SD (SD-L), and Alzheimer's disease (AD). This study also aimed to identify clinical factors related to caregiver burden for bvFTD, SD-R, and SD-L. METHODS: The neuropsychiatric symptoms of 28 patients with bvFTD, 14 patients with SD-R, 24 patients with SD-L, and 43 patients with AD were evaluated using the Neuropsychiatric Inventory (NPI) and the Stereotypy Rating Inventory (SRI). Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Dementia severity was assessed using the Clinical Dementia Rating. Activities of daily living were assessed using the Lawton Instrument Activities of Daily Living (IADL) scale and the Physical Self-Maintenance Scale. We compared the NPI and SRI scores among the four groups using the Kruskal-Wallis test. In addition, clinical factors related to caregiver burden, represented by the Japanese version of the Zarit Burden Interview (J-ZBI), were analyzed using multiple regression analysis in the bvFTD, SD-R, and SD-L groups. RESULTS: The NPI total score and the NPI subscale scores of apathy and disinhibition were significantly higher in the bvFTD group than in the SD-L and AD groups. The SD-R group scores were closer to those of the bvFTD group than the SD-L group. The SRI total score and SRI subscale scores for eating and cooking and speaking were significantly higher in the bvFTD, SD-R, and SD-L groups than in the AD group. The NPI total score was significantly associated with the J-ZBI score in the bvFTD group. The NPI total score and Lawton IADL scale score were independently associated with the J-ZBI score in the SD-R group. Furthermore, the NPI total score and MMSE score were independently associated with the J-ZBI score in the SD-L group. CONCLUSIONS: SD-R seemed to be a similar condition to bvFTD rather than SD-L regarding behavioral symptoms. Our results suggest that each frontotemporal dementia subgroup requires different approaches to reduce the caregiver burden. CI - (c) 2021. The Author(s). FAU - Sato, Shunsuke AU - Sato S AUID- ORCID: 0000-0002-1378-4428 AD - Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka,, Suita City,, Osaka, 565-0871, Japan. s.sato1815@gmail.com. AD - Department of Psychiatry, Osaka General Medical Center, Osaka, Japan. s.sato1815@gmail.com. FAU - Hashimoto, Mamoru AU - Hashimoto M AD - Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka,, Suita City,, Osaka, 565-0871, Japan. FAU - Yoshiyama, Kenji AU - Yoshiyama K AD - Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka,, Suita City,, Osaka, 565-0871, Japan. FAU - Kanemoto, Hideki AU - Kanemoto H AD - Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka,, Suita City,, Osaka, 565-0871, Japan. FAU - Hotta, Maki AU - Hotta M AD - Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka,, Suita City,, Osaka, 565-0871, Japan. AD - Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. FAU - Azuma, Shingo AU - Azuma S AD - Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka,, Suita City,, Osaka, 565-0871, Japan. AD - Department of Psychiatry, Mizuma Hospital, Kaizuka, Japan. FAU - Suehiro, Takashi AU - Suehiro T AD - Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka,, Suita City,, Osaka, 565-0871, Japan. FAU - Kakeda, Kyosuke AU - Kakeda K AD - Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka,, Suita City,, Osaka, 565-0871, Japan. FAU - Nakatani, Yoshitaka AU - Nakatani Y AD - Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka,, Suita City,, Osaka, 565-0871, Japan. AD - Department of Psychiatry, Osaka Psychiatric Medical Center, Osaka, Japan. FAU - Umeda, Sumiyo AU - Umeda S AD - Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka,, Suita City,, Osaka, 565-0871, Japan. AD - Department of Psychiatry, Daini Osaka Police Hospital, Osaka, Japan. FAU - Fukuhara, Ryuji AU - Fukuhara R AD - Department of Neuropsychiatry, Kumamoto University Hospital, Kumamoto, Japan. FAU - Takebayashi, Minoru AU - Takebayashi M AD - Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. AD - Department of Neuropsychiatry, Kumamoto University Hospital, Kumamoto, Japan. FAU - Ikeda, Manabu AU - Ikeda M AD - Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka,, Suita City,, Osaka, 565-0871, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20211009 PL - England TA - Alzheimers Res Ther JT - Alzheimer's research & therapy JID - 101511643 SB - IM MH - Activities of Daily Living MH - *Alzheimer Disease MH - Behavioral Symptoms/etiology MH - Caregiver Burden MH - Caregivers MH - Cross-Sectional Studies MH - *Frontotemporal Dementia MH - Humans MH - Neuropsychological Tests PMC - PMC8502362 OTO - NOTNLM OT - Alzheimer's disease OT - Behavioral symptoms OT - Caregiver burden OT - Dementia OT - Frontotemporal dementia OT - Frontotemporal lobar degeneration OT - Primary progressive aphasia OT - Progressive non-fluent aphasia OT - Right temporal lobe atrophy OT - Semantic dementia COIS- The authors declare that they have no competing interests. EDAT- 2021/10/11 06:00 MHDA- 2021/10/29 06:00 PMCR- 2021/10/09 CRDT- 2021/10/10 20:35 PHST- 2021/03/15 00:00 [received] PHST- 2021/09/28 00:00 [accepted] PHST- 2021/10/10 20:35 [entrez] PHST- 2021/10/11 06:00 [pubmed] PHST- 2021/10/29 06:00 [medline] PHST- 2021/10/09 00:00 [pmc-release] AID - 10.1186/s13195-021-00908-2 [pii] AID - 908 [pii] AID - 10.1186/s13195-021-00908-2 [doi] PST - epublish SO - Alzheimers Res Ther. 2021 Oct 9;13(1):166. doi: 10.1186/s13195-021-00908-2.